Search results for "Melt mixing"
showing 4 items of 14 documents
Integration of PCL and PLA in a monolithic porous scaffold for interface tissue engineering.
2016
A novel bi-layered multiphasic scaffold (BLS) have been fabricated for the first time by combining melt mixing, compression molding and particulate leaching. One layer has been composed by polylactic acid (PLA) presenting pore size in the range of 90-110µm while the other layer has been made of polycaprolactone (PCL) with pores ranging from 5 to 40µm. The different chemo-physical properties of the two biopolymers combined with the tunable pore architecture permitted to realize monolithic functionally graded scaffolds engineered to be potentially used for interface tissues regenerations. BLS have been characterized from a morphological and a mechanical point of view. In particular, mechanica…
Manufacturing, structure and properties of recycled polyethylene terephthalate /liquid crystal polymer/montmorillonite clay nanocomposites
2013
Polyethylene terephthalate (PET)/liquid crystal polymer (LCP)/monthmorillonite clay (MMT) compositions were obtained by melt mixing. Their mechanical, structural, rheological and thermal properties were investigated.
Melt Processed PCL/PEG Scaffold with Discrete Pore Size Gradient for Selective Cellular Infiltration
2016
In order to develop scaffold able to mimic the natural gradient properties of tissues, biphasic and triphasic approaches were adopted. In this work, polycaprolactone/polyethylene glycol (PCL/PEG) scaffolds were prepared by using a combination of melt mixing and selective leaching without harmful solvents. The method permitted to develop three-layer scaffolds with high control of porosity and pore size. The mechanical properties were evaluated under physiological condition in order to simulate the real conditions of work. Co-culture of osteoblastic and fibroblastic mice cells were carried out in order to study the differential cellular permeation through the different pore size layers.
Three-layered porous device in PCL/PEG blend for interface tissue engineering
2016
Tissue interfaces, such as cartilage-to-bone, exhibit anisotropic structural properties, which gradually vary from one tissue to another. Consequently a regenerative scaffold designed for interface tissues should exhibit a gradient in composition, structure and mechanical features, mimicking those of the native zones. In particular, the architecture of pores plays a central role. Indeed, a biomedical implant should be designed with porosityand pore size gradients simulating the structure of the two interface tissues. One of the most common techniques to prepare porous scaffolds is the particulate leaching method, which involves the selective leaching of a mineral or organic compound as poro…