Search results for "Memory"
showing 10 items of 2004 documents
Experimental Preemptive Immunotherapy of Murine Cytomegalovirus Disease with CD8 T-Cell Lines Specific for ppM83 and pM84, the Two Homologs of Human …
2001
ABSTRACTCD8 T cells are the principal antiviral effectors controlling cytomegalovirus (CMV) infection. For human CMV, the virion tegument protein ppUL83 (pp65) has been identified as a source of immunodominant peptides and is regarded as a candidate for cytoimmunotherapy and vaccination. Two sequence homologs of ppUL83 are known for murine CMV, namely the virion protein ppM83 (pp105) expressed late in the viral replication cycle and the nonstructural protein pM84 (p65) expressed in the early phase. Here we show that ppM83, unlike ppUL83, is not delivered into the antigen presentation pathway after virus penetration before or in absence of viral gene expression, while other virion proteins o…
Long-term working memory and interrupting messages in human – computer interaction
2004
The extent to which memory for information content is reliable, trustworthy, and accurate is crucial in the information age. Being forced to divert attention to interrupting messages is common, however, and can cause memory loss. The memory effects of interrupting messages were investigated in three experiments. In Experiment 1, attending to an interrupting message decreased memory accuracy. Experiment 2, where four interrupting messages were used, replicated this result. In Experiment 3, an interrupting message was shown to be most disturbing when it was semantically very close to the main message. Drawing from a theory of long-term working memory it is argued that interrupting messages ca…
Memes y Políticas de Identidad. El poder de la risa en la cultura digital
2020
Una de las formas más arcaicas y evidentes de la comunicación es reír. En la cultura digital, las imágenes humorísticas, en concreto las satíricas, se unen a la sociedad de masas mediante la configuración de ideas e identidades. Durante el s. XIX, la identidad y el nacionalismo han sido dos caras de la misma moneda. Su representación por medio de símbolos e ideas siguen estando patentes en la actualidad. En el ámbito nacional, la identidad catalana no solo sigue teniendo una vinculación nacionalista propia del XIX, sino que ha devenido en un fenómeno de identidad propio unido asimismo al procés de independencia. Por eso mismo y con el objetivo de poner en relieve el poder de las imágenes hu…
Letteratura e scienze del bios: il caso di Siri Hustvedt
2019
Negli ultimi anni anche la teoria letteraria in Italia ha cominciato ad affrontare la questione del significato biologico della narrazione e della letteratura. Il presupposto di questo interesse sta nel riconoscimento che la narrazione può essere a pieno titolo considerata un “comportamento” tipico della specie Homo sapiens, non foss’altro perché è un fenomeno che riguarda tutta la specie (in tutte le latitudini e a tutte le altezze cronologiche) e può essere considerata nel quadro delle attitudini cognitive che hanno permesso agli umani di costruire una nicchia ecologica che è il prodotto dell’interazione tra evoluzione biologica e costruzioni culturali.
Huculska pamięć ludowa w ujęciu Stanisława Vincenza
2012
W artykule przedstawiono problem zbiorowej pamięci ludowej oraz jej przejawów w kulturze oralnej, mentalności oraz światopoglądzie Hucułów, odzwierciedlonych w epopei Stanisława Vincenza "Na wysokiej połoninie".
Inhibition of murine IgE and immediate cutaneous hypersensitivity responses to ovalbumin by the immunomodulatory agent leflunomide
1999
SUMMARYLeflunomide has been identified as an immunoregulatory and anti-inflammatory compound. Allergic disease is characterized by elevated serum IgE levels, production of allergen-specific IgE and the release of inflammatory mediators from mast cells and granulocytes. Here we demonstrate, using an in vivo murine model, the ability of leflunomide to down-regulate levels of total and allergen-specific serum IgE production. Mice receiving leflunomide (45 mg/kg) orally at the time of primary immunization with ovalbumin adsorbed to aluminium hydroxide adjuvant, showed a reduction in total serum IgE levels of 95%, 41% and 32% following primary, secondary and tertiary immunizations, respectively …
Sex Classification of Face Areas
1998
Human subjects and an artificial neural network, composed of an autoassociative memory and a perceptron, gender classified the same 160 frontal face images (80 male and 80 female). All 160 face images were presented under three conditions (1) full face image with the hair cropped (2) top portion only of the Condition 1 image (3) bottom portion only of the Condition 1 image. Predictions from simulations using Condition 1 stimuli for training and testing novel stimuli in Conditions 1, 2, and 3, were compared to human subject performance. Although the network showed a fair ability to generalize learning to new stimuli under the three conditions, performing from 66 to 78% correctly on novel fa…
Soft errors in commercial off-the-shelf static random access memories
2016
International audience; This article reviews state-of-the-art techniques for the evaluation of the effect of radiation on static random access memory (SRAM). We detailed irradiation test techniques and results from irradiation experiments with several types of particles. Two commercial SRAMs, in 90 and 65 nm technology nodes, were considered as case studies. Besides the basic static and dynamic test modes, advanced stimuli for the irradiation tests were introduced, as well as statistical post-processing techniques allowing for deeper analysis of the correlations between bit-flip cross-sections and design/architectural characteristics of the memory device. Further insight is provided on the …
Heavy-Ion Radiation Impact on a 4 Mb FRAM Under Different Test Modes and Conditions
2016
International audience; The impact of heavy-ions on commercial Ferroelectric Memories (FRAMs) is analyzed. The influence of dynamic and static test modes as well as several stimuli on the error rate of this memory is investigated. Static test results show that the memory is prone to temporary effects occurring in the peripheral circuitry, with a possible effect due to fluence. Dynamic tests results show a high sensitivity of this memory to switching activity of this peripheral circuitry.
T-Cell Subsets (TCM, TEM, TEMRA) and Poly-Functional Immune Response in Patients with Human Immunodeficiency Virus (HIV) Infection and Different T-CD…
2019
OBJECTIVE: Dynamic changes of cytotoxic T cell responses against Human Immunodeficiency Virus 1 (HIV-1) infection have been the subject of an innovative investigation using antiretroviral therapy (ART). Currently, human CD8 naïve central memory (TCM), effector memory (TEM), and effector memory cells re-expressing CD45RA (TEMRA) T-cells have been thoroughly studied with ART. CD45RA is a marker usually found on naïve T-cells. MATERIALS AND METHODS: We performed a longitudinal study of mono-/polyfunctional T-cells in the peripheral blood while targeting three functionally distinct cell populations of CD4+ and CD8+ T-cells (single IL2 and IFN-γ, dual IL2/IFN-γ) in 50 HIV-1 patients. These patie…