Search results for "Memory"
showing 10 items of 2004 documents
Enrichment of Immediate-Early 1 (m123/pp89) Peptide-Specific CD8 T Cells in a Pulmonary CD62LloMemory-Effector Cell Pool during Latent Murine Cytomeg…
2000
ABSTRACTInterstitial cytomegalovirus (CMV) pneumonia is a clinically relevant complication in recipients of bone marrow transplantation (BMT). Recent data for a model of experimental syngeneic BMT and concomitant infection of BALB/c mice with murine CMV (mCMV) have documented the persistence of tissue-resident CD8 T cells after clearance of productive infection of the lungs (J. Podlech, R. Holtappels, M.-F. Pahl-Seibert, H.-P. Steffens, and M. J. Reddehase, J. Virol. 74:7496–7507, 2000). It was proposed that these cells represent antiviral “standby” memory cells whose functional role might be to help prevent reactivation of latent virus. The pool of pulmonary CD8 T cells was composed of two…
A central role for Notch in effector CD8(+) T cell differentiation.
2014
Activated CD8(+) T cells choose between terminal effector cell (TEC) or memory precursor cell (MPC) fates. We found that the signaling receptor Notch controls this 'choice'. Notch promoted the differentiation of immediately protective TECs and was correspondingly required for the clearance of acute infection with influenza virus. Notch activated a major portion of the TEC-specific gene-expression program and suppressed the MPC-specific program. Expression of Notch was induced on naive CD8(+) T cells by inflammatory mediators and interleukin 2 (IL-2) via pathways dependent on the metabolic checkpoint kinase mTOR and the transcription factor T-bet. These pathways were subsequently amplified d…
Mechanisms underlying lineage commitment and plasticity of human γδ T cells.
2012
Phenotypic and functional heterogeneity are the hallmarks of effector and memory T cells. Upon antigen stimulation, γδ T cells differentiate into two major types of memory T cells: central memory cells, which patrol the blood and secondary lymphoid organs, and effector memory cells, which migrate to peripheral tissues. γδ T cells display in vitro a certain degree of plasticity in their function that is reminiscent of that which is observed in conventional CD4 T cells. Similar to CD4 T cells, in which a plethora of specialized subsets affect the host response, γδ T cells may readily and rapidly assume distinct Th1-, Th2-, Th17-, T(FH) and T regulatory-like effector functions, suggesting that…
Differentiation of Effector/Memory Vδ2 T Cells and Migratory Routes in Lymph Nodes or Inflammatory Sites
2003
Vδ2 T lymphocytes recognize nonpeptidic antigens without presentation by MHC molecules and mount both immediate effector functions and memory responses after microbial infection. However, how Vδ2 T cells mediate different facets of a memory response remains unknown. Here, we show that the expression of CD45RA and CD27 antigens defines four subsets of human Vδ2 T cells with distinctive compartmentalization routes. Naive CD45RA+CD27+ and memory CD45RA−CD27+ cells express lymph node homing receptors, abound in lymph nodes, and lack immediate effector functions. Conversely, memory CD45RA−CD27− and terminally differentiated CD45RA+CD27− cells, which express receptors for homing to inflamed tissu…
‘If-then’ but when? Effects of implementation intentions on children’s and adolescents’ prospective memory
2021
Abstract Prospective memory (PM), the ability to initiate and implement delayed intentions, increases across childhood and adolescence. Previous evidence on older adults indicated beneficial effects of implementation intentions (an encoding strategy) on individuals’ PM performance; especially when cognitive control demands were high and availability of cognitive resources low. This research program set out to investigate the impact of implementation intentions on children’s and adolescents’ PM while simultaneously varying cognitive control demands of the PM paradigm. Across two studies, implementation intention encoding was contrasted with standard encoding. In addition, Study 1 manipulated…
La dimensione tecnologica del museo: forme, tecniche, "identità mutanti" tra storia e contemporaneità
2005
Nella cultura contemporanea il tema della conservazione dell’eredità storica, della rappresentazione e della trasmissibilità dell’arte è argomento ampiamente dibattuto. La forza culturale del museo, detentore dell’eredità, può essere interpretata secondo diverse traiettorie di forme. La memoria intende esprimersi sulle origini e sul significato della "macchina museale" attraverso l’analisi critica dell’oggetto, sia esso contenitore, palco di rappresentazione o scena interattiva. Sonda i processi di comunicazione relativamente alla forma architettonica, alla funzione ed alla fruizione del prodotto espositivo. Tenendo conto delle diverse scuole di pensiero sulla spettacolarizzazione dell’arte…
L'archeologia industriale: una storia di edilizia, economia ed abbandono. La Manifattura Tabacchi di Palermo
2016
Nella storia del nostro paese ci sono stati periodi di grande lustro economico, nei quali fiorirono fabbriche che producevano alacremente e che davano lavoro a migliaia di persone e rappresentando per alcuni centri urbani una enorme risorsa ed un punto di riferimento. Si tratta in genere di complessi edificati, all'interno del tessuto urbano o poco fuori da esso, che dalla loro realizzazione hanno influenzato economia e costumi degli abitanti del luogo, segnando spesso la sua stessa storia. Le fabbriche hanno fornito anche l'occasione di sperimentare tecniche costruttive nuove, rese necessarie dalle grandi luci da coprire o dai carichi da sostenere, e soluzioni funzionali sempre diverse, da…
Adaptive memory programming for the dynamic bipartite drawing problem
2020
Abstract The bipartite drawing problem is a well-known NP-hard combinatorial optimization problem with numerous applications. The aim is to minimize the number of edge crossings in a two-layer graph, in which the edges are drawn as straight lines. We consider the dynamic variant of this problem, called the dynamic bipartite drawing problem (DBDP), which consists of adding (resp. or removing) vertices and edges to (resp. or from) a given bipartite drawing, thereby obtaining a new drawing with a layout similar to that of the original drawing. To solve this problem, we propose a tabu search method that incorporates adaptive memory to search the solution space efficiently. In this study, we com…
Differences in familiarity according to the cognitive reserve of healthy elderly people / Diferencias en familiaridad en función de la reserva cognit…
2014
AbstractThis study examines the relationship between cognitive reserve and familiarity processes in recognition memory. We hypothesize that people with high cognitive reserve are able to better compensate in alternative information retrieval processes. Forty-five participants, divided into high and low cognitive reserve groups, conducted a recognition experiment where they were asked to discriminate between studied and non-studied words that varied in perceptual familiarity. The results indicated that participants were able to use perceptual familiarity to improve their level of recognition. More importantly, people with high cognitive reserve used familiarity better than those with low cog…
Drug-induced expansion and differentiation of Vγ9Vδ2 T cells in vivo: The role of exogenous IL-2
2005
Human Vgamma9Vdelta2 T cells recognize nonpeptidic Ags generated by the 1-deoxy-d-xylulose 5-phosphate (many eubacteria, algae, plants, and Apicomplexa) and mevalonate (eukaryotes, archaebacteria, and certain eubacteria) pathways of isoprenoid synthesis. The potent Vgamma9Vdelta2 T cell reactivity 1) against certain cancer cells or 2) induced by infectious agents indicates that therapeutic augmentations of Vgamma9Vdelta2 T cell activities may be clinically beneficial. The functional characteristics of Vgamma9Vdelta2 T cells from Macaca fascicularis (cynomolgus monkey) are very similar to those from Homo sapiens. We have found that the i.v. administration of nitrogen-containing bisphosphonat…