Search results for "Mental Model"

Compositional design of animation improves comprehension of complex dynamics

2016

International audience; Learners have difficulty in decomposing conventionally designed animations to obtain raw material suitable for building high quality mental models. A composition approach to designing animations based on the Animation Processing Model was developed as a principled alternative to prevailing approaches. It provides learners with pre-decomposed material that is structured and sequenced to facilitate the relation building required for effective mental model construction. Study of a compositional animation that presented material in a contiguous fashion resulted in higher quality mental models of a piano mechanism than non-contiguous or control (conventional) versions. Ey…

Recent Advances on the Innate Immune Response to Coxiella burnetii.

2021

Coxiella burnetii is an obligate intracellular Gram-negative bacterium and the causative agent of a worldwide zoonosis known as Q fever. The pathogen invades monocytes and macrophages, replicating within acidic phagolysosomes and evading host defenses through different immune evasion strategies that are mainly associated with the structure of its lipopolysaccharide. The main transmission routes are aerosols and ingestion of fomites from infected animals. The innate immune system provides the first host defense against the microorganism, and it is crucial to direct the infection towards a self-limiting respiratory disease or the chronic form. This review reports the advances in understanding…

A discrete mathematical model for addictive buying: Predicting the affected population evolution

2011

This paper deals with the construction of a discrete mathematical model for addictive buying. Firstly, identifications of consumers buying behavior are performed by using multivariate statistical techniques based on real data bases and sociological approaches. Then the population is divided into appropriate groups according to the level of overbuying and a discrete compartmental model is constructed. The future short term addicted population is computed assuming several future economic scenarios. © 2010 Elsevier Ltd.

Profilin 1 negatively regulates osteoclast migration in postnatal skeletal growth, remodeling, and homeostasis in mice

2019

ABSTRACT Profilin 1 (Pfn1), a regulator of actin polymerization, controls cell movement in a context‐dependent manner. Pfn1 supports the locomotion of most adherent cells by assisting actin‐filament elongation, as has been shown in skeletal progenitor cells in our previous study. However, because Pfn1 has also been known to inhibit migration of certain cells, including T cells, by suppressing branched‐end elongation of actin filaments, we hypothesized that its roles in osteoclasts may be different from that of osteoblasts. By investigating the osteoclasts in culture, we first verified that Pfn1‐knockdown (KD) enhances bone resorption in preosteoclastic RAW264.7 cells, despite having a compa…

Use of photoplethysmography to determine gastrointestinal perfusion pressure: an experimental canine model.

2002

<i>Objectives:</i> To develop an experimental model to assess the parietal perfusion pressure (PPP) of the digestive tract using photoplethysmography. <i>Materials and Methods:</i> Twenty-two mongrel dogs were used. Progressive external compression was applied to the intestinal wall and the PPP was assessed with photoplethysmography. The study group was divided into two groups. In group 1 PPP was measured at the levels of the stomach, duodenum, jejunum and transverse colon. In group 2 PPP was measured after temporary occlusion of the truncal and marginal circulation of the jejunum to provide further variables. <i>Results:</i> The PPP decreased significant…

PMT: New analytical framework for automated evaluation of geo-environmental modelling approaches

2019

Geospatial computation, data transformation to a relevant statistical software, and step-wise quantitative performance assessment can be cumbersome, especially when considering that the entire modelling procedure is repeatedly interrupted by several input/output steps, and the self-consistency and self-adaptive response to the modelled data and the features therein are lost while handling the data from different kinds of working environments. To date, an automated and a comprehensive validation system, which includes both the cutoff-dependent and –independent evaluation criteria for spatial modelling approaches, has not yet been developed for GIS based methodologies. This study, for the fir…

The analgesic-antiinflammatory extract fromAraujia sericifera lacks ulcerogenic activity on stress-gastric damage model

1995

The present study evaluates the ulcerogenic activity of the hexane extract from dry fruits of Araujia sericifera in an experimental model of cold-restraint stress. Treatment of rats with 200 mg/kg (i.p.) of hexane extract did not affect the gastric lesions induced by cold-restraint stress. However, it was confirmed that a dose of 300 mg/kg (i.p.) of acetylsalicylic acid (ASA) which induced a similar analgesic-antiinflammatory effect, increased significantly the level of gastric damage. Thus, the hexane extract from the fruits of A. sericifera seems to possess analgesic-antiinflammatory properties which are not linked to gastrolesive effects.

Isolated myocardiocytes and DNA synthesis: a possible experimental model to predict the in vivo cardiotoxicity

1989

Design of a System to Compose 50 Hz Alternating and Static Magnetic Field From Induction Coil and Permanent Magnets

2020

We demonstrate a technical solution to achieve an intense 50 Hz alternating magnetic field and a static magnetic field made by a permanent magnet at the same place. A compact coil built using the Bitter coil concept is customized to support alternating current, thus creating an alternating magnetic field. A complementary permanent magnet assembly is built around it to achieve the superposition of both fields along the axis of symmetry. Results from the experimental model are compared to both numerical and analytical models.

Comparison of complex fractionated atrial electrograms at cellular scale using numerical and experimental models.

2010

This study investigates the existence of the pseudo complex fractionated atrial electrogram (CFAE) at cellular level. Our assumptions are based on the fact that CFAEs are linked to the generation of the spiral waves. These are created using a numerical model and an experimental model of in vitro culture of neonatal rats cardiac cells. Pseudo bipolar electrograms resulting from these two models are compared qualitatively and some patterns could be identified as CFAE signature.