Search results for "Mesh"

Splice donor site mutation in the lysosomal neuraminidase gene causing exon skipping and complete loss of enzyme activity in a sialidosis patient.

2001

Sialidosis is a lysosomal storage disease caused by the deficiency of K K-N-acetylneuraminidase (NEU1; sialidase), the key enzyme for the intralysosomal catabolism of sialylated glycoconjugates. We have identified a homozygous transversion in the last intron (IVSE +1 Gs C) in neu1 of a sialidosis patient. Sequencing of the truncated cDNA revealed an alternatively spliced neu1 transcript which lacks the complete sequence of exon 5. Skipping of exon 5 leads to a frameshift and results in a premature termination codon. This is the first description of an intronic point mutation causing a complete deficiency of the lysosomal neuraminidase activity. fl 2001 Federation of Euro- pean Biochemical S…

Multi-scale computational homogenization with applications to masonry structures

Multiscale Particle Method in Solving Partial Differential Equations

2007

A novel approach to meshfree particle methods based on multiresolution analysis is presented. The aim is to obtain numerical solutions for partial differential equations by avoiding the mesh generation and by employing a set of particles arbitrarily placed in problem domain. The elimination of the mesh combined with the properties of dilation and translation of scaling and wavelets functions is particularly suitable for problems governed by hyperbolic partial differential equations with large deformations and high gradients.

FE·Meshless multiscale modeling of heterogeneous periodic materials

2013

The computational mutiscale modeling of periodic heterogeneous materials, characterized by the assembly of units and joints, represents a compromise between the inaccuracy resulting from the macro modeling approach and the computational effort of the meso modeling. Assuming that the heterogeneities are orders of magnitude smaller than the structure dimensions, according to the multiscale approach, the macroscopic stresses and strains around a certain point can be found by averaging the stresses and the strains in a small representative part of the microstructure or a representative volume element (RVE) attributed to that point. A first-order two-scale scheme has been used to model heterogen…

Advancements on the FE·Meshless CH for the analysis of heterogeneous periodic materials

Over the last few years, the intrinsic role of different spatial scales in the mechanics of materials has been well recognized. Generally, two main different scales can be identified in the heterogeneous materials: the macroscopic level, which coincides with the global structural one, and the mesoscopic level, that is the scale at which the heterogeneities can be identified and where the most relevant nonlinear mechanical phenomena occur. In this framework, substantial progress has been made in the two-scale computational homogenization (CH). This method is essentially based on the on the fly assessment of the macroscopic constitutive behavior from the boundary value problem (BVP) of a stat…

CH of masonry materials via meshless meso-modeling

2014

In the present study a multi-scale computational strategy for the analysis of masonry structures is presented. The structural macroscopic behaviour is obtained making use of the Computational Homogenization (CH) technique based on the solution of the boundary value problem (BVP) of a detailed Unit Cell (UC) chosen at the meso-scale and representative of the heterogeneous material. The smallest UC is composed by a brick and half of its surrounding joints, the former assumed to behave elastically while the latter considered with an elastoplastic softening response. The governing equations at the macroscopic level are formulated in the framework of finite element method while the Meshless Meth…

Is the beta3-adrenoceptor (ADRB3) a potential target for uterorelaxant drugs?

2007

International audience; The management of premature birth still remains unsatisfactory. Since the relative lack of efficiency and/or safety of current tocolytic agents have been highlighted, it is necessary to develop new uterorelaxant drugs deprived of important maternal and foetal side effects. Our work reported in this review focuses on a potential new target for tocolytic drugs, the beta3-adrenoceptor (ADRB3). This third type of ADRB is shown to be present and functional in human myometrium. We demonstrated that ADRB3 agonists are able to inhibit in-vitro spontaneous contractions of myometrial strips, via a cyclic AMP-mediated pathway. Furthermore, we established that ADRB3 is the predo…

The effect of experimental and clinical musculoskeletal pain on spinal and supraspinal projections to motoneurons and motor unit properties in humans…

2021

Background and Objective Numerous studies have examined the influence of pain on spinal reflex excitability, motor unit behaviour and corticospinal excitability. Nevertheless, there are inconsistencies in the conclusions made. This systematic review sought to understand the effect of pain on spinal and supraspinal projections to motoneurons and motor unit properties by examining the influence of clinical or experimental pain on the following three domains: H-reflex, corticospinal excitability and motor unit properties. Databases and Data Treatment MeSH terms and preselected keywords relating to the H-reflex, motor evoked potentials and motor unit decomposition in chronic and experimental pa…

DNMT3A mutations Predict for Inferior Outcome in NPM1-Wildtype and Molecular Unfavorable Cytogenetically-Normal Acute Myeloid Leukemia: A Study of th…

2011

Abstract Abstract 415 Background: Alteration of DNA methylation, a hallmark of epigenetic modification, is currently discussed as one important pathomechanism in leukemogenesis. Using a next-generation sequencing approach, a frameshift mutation of the gene encoding the DNA methyltransferase (DNMT3A) in an acute myeloid leukemia (AML) case was identified. DNMT3A catalyses the addition of a methyl group to the cytosine residue of CpG dinucleotides, thereby affecting promoter methylation status and gene expression. Subsequent sequencing analysis in an independent cohort of 288 AML patients (pts) revealed DNMT3A mutations (DNMT3Amut) in 22% of the pts; mutations were associated with intermediat…

A Smoothed Particle Image Reconstruction method

2010

Many image processing techniques work with scattered data distribution usually employing grid based methods leading to numerical problems. To address this issue, a numerical method avoiding mesh generation can be used. Such a method performs an integral representation by means of a smoothing kernel function and, in the discrete formulation, involves domain particles. In this paper the meshless Smoothed Particle Hydrodynamics method is proposed in the Image Reconstruction context and a new computational strategy called Smoothed Particle Image Reconstruction is presented; the new method is based on a scatter approach and several innovative ideas are introduced in order to improve the computat…