Search results for "Mesh"
showing 10 items of 885 documents
Simulation of the Propagation of Tsunamis in Coastal Regions by a Two-Dimensional Non-Hydrostatic Shallow Water Solver
2017
Due to the enormous damages and losses of human lives in the inundated regions, the simulation of the propagation of tsunamis in coastal areas has received an increasing interest of the researchers. We present a 2D depth-integrated, non- hydrostatic shallow waters solver to simulate the propagation of tsunamis, solitary waves and surges in coastal regions. We write the governing continuity and momentum equations in conservative form and discretize the domain with unstructured triangular Generalized Delaunay meshes. We apply a fractional- time-step procedure, where two problems (steps) are consecutively solved. In the first and in the second step, we hypothesize a hydrostatic and a non-hydro…
Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy
2020
AbstractThe current pandemic situation caused by the Betacoronavirus SARS-CoV-2 (SCoV2) highlights the need for coordinated research to combat COVID-19. A particularly important aspect is the development of medication. In addition to viral proteins, structured RNA elements represent a potent alternative as drug targets. The search for drugs that target RNA requires their high-resolution structural characterization. Using nuclear magnetic resonance (NMR) spectroscopy, a worldwide consortium of NMR researchers aims to characterize potential RNA drug targets of SCoV2. Here, we report the characterization of 15 conserved RNA elements located at the 5′ end, the ribosomal frameshift segment and t…
Mesh complications following prolapse surgery: management and outcome.
2011
Abstract Objective This is a description of complications following prolapse surgery with the use of alloplastic materials, the management and outcome. Study design 54 women have been referred to Mainz, urogynecology referral center due to complications following mesh-augmented prolapse surgery. Results The complaints who lead to the admission are expressed by the new terminology and standardized classification for complications arising directly from the insertion of prostheses and grafts in female pelvic floor surgery [1] . Pain (66.7%), mesh erosion (55.6%) and vaginal discharge (48.1%) were the most frequent complaints. Revision was performed after a median time of 27.2 months post mesh …
The impact of tumor nitric oxide production on VEGFA expression and tumor growth in a zebrafish rat glioma xenograft model.
2015
International audience; To investigate the effect of nitric oxide on tumor development, we established a rat tumor xenograft model in zebrafish embryos. The injected tumor cells formed masses in which nitric oxide production could be detected by the use of the cell-permeant DAF-FM-DA (diaminofluorophore 4-amino-5-methylamino-2'-7'-difluorofluorescein diacetate) and DAR-4M-AM (diaminorhodamine-4M). This method revealed that nitric oxide production could be co-localized with the tumor xenograft in 46% of the embryos. In 85% of these embryos, tumors were vascularized and blood vessels were observed on day 4 post injection. Furthermore, we demonstrated by qRT-PCR that the transplanted glioma ce…
Saliency Features for 3D CAD-Data in the Context of Sampling-Based Motion Planning
2021
In this paper, we consider disassembly scenarios for real-world 3D CAD-data, where each component is defined by a triangle mesh. For a fast construction of collision-free disassembly paths, common approaches use sampling-based rigid body motion planning which is well studied in the literature. One fact that has so far received little attention is that in industrial disassembly scenarios components are often attached to each other with flexible fastening elements like clips. In the planning process, the fastening elements show the following characteristics: 1) They can cause complex non-linear disassembly paths. 2) They are often deformable. 3) They are usually modeled in a relaxed state and…
Lead concentrations in feathers and blood of common blackbirds (Turdus merula) and in earthworms inhabiting unpolluted and moderately polluted urban …
2006
9 pages; International audience; Despite the dramatic decrease of atmospheric lead (Pb) concentrations in urban areas of most industrialised countries, we hypothesised that urban common blackbirds (Turdus merula) may still be contaminated by Pb concentrations of toxicological concern due to transfer from soil through the food chain. We sampled blackbirds and earthworms, one of their main preys, in Besan?, a middle-size city of Eastern France (where atmospheric Pb concentrations decreased from 0.5 microg/m(3) in 1987 to nearly 0 in 2002) and in a rural reference site. Lead concentrations were determined in the tissues of the different functional groups of earthworms (anecic, epigeous and end…
Analysis of integrated virological and epidemiological reports of norovirus outbreaks collected within the Foodborne Viruses in Europe network from 1…
2008
ABSTRACT The Foodborne Viruses in Europe network has developed integrated epidemiological and virological outbreak reporting with aggregation and sharing of data through a joint database. We analyzed data from reported outbreaks of norovirus (NoV)-caused gastroenteritis from 13 European countries (July 2001 to July 2006) for trends in time and indications of different epidemiology of genotypes and variants. Of the 13 countries participating in this surveillance network, 11 were capable of collecting integrated epidemiological and virological surveillance data and 10 countries reported outbreaks throughout the entire period. Large differences in the numbers and rates of reported outbreaks pe…
A Novel Wireless Sensor Network for Electric Power Metering
2013
Wireless sensor network with lightweight and efficient communication infrastructures are today a great interest, both at research and industrial level, as they are the basis for reliable monitoring services. Mesh networks are ideal candidates in this scenario, as they can be very fault-tolerant. After introducing wireless network systems requirements, we show the design of a mesh network routing protocol based on AODV schemas. Its implementation runs on top of low-cost off-the-shelf components, and allowed us to build a custom power meter wireless sensor node.
Energy-aware design for wireless mesh networks
2014
International audience; Wireless mesh networks (WMNs) are the next step in the development of the wireless architecture, delivering wireless services for a large variety of users in personal, local, campus, and metropolitan areas. Energy efficiency solutions are becoming more vital for both local access networks and wireless networks and Green IT has attracted a considerable attention. However, the application of green network for wireless mesh networks has seldom been described in the literature. However, WMNs infrastructure devices are always active. Thus, during lower traffic periods the energy consumption is the same as in busy hours, while it would be possible to save a large amount of…
Wee1 inhibition potentiates Wip1-dependent p53-negative tumor cell death during chemotherapy
2016
AbstractInactivation of p53 found in more than half of human cancers is often associated with increased tumor resistance to anti-cancer therapy. We have previously shown that overexpression of the phosphatase Wip1 in p53-negative tumors sensitizes them to chemotherapeutic agents, while protecting normal tissues from the side effects of anti-cancer treatment. In this study, we decided to search for kinases that prevent Wip1-mediated sensitization of cancer cells, thereby interfering with efficacy of genotoxic anti-cancer drugs. To this end, we performed a flow cytometry-based screening in order to identify kinases that regulated the levels of γH2AX, which were used as readout. Another criter…