6533b821fe1ef96bd127baad
RESEARCH PRODUCT
Analysis of integrated virological and epidemiological reports of norovirus outbreaks collected within the Foodborne Viruses in Europe network from 1 July 2001 to 30 June 2006.
Y. Van DuynhovenJudith KochAnnelies KronemanC.-h. Von BonsdorffG. Hernandéz-pezziMarkku KuusiAlbert BoschEckart SchreierMarina HöhneJ. BuesaP. MckeownI. Di BartoloM. IturrizaFranco Maria RuggeriSuzie CoughlanE. IsakbaevaK. KrisztalovicsMarion KoopmansPierre PothierBrian T. FoleyJim GrayAnne GallayKirsti VainioA. Sanchez FauquierChristina K. JohnsenKjell-olof HedlundGyörgy SzücsJ. Zimsek MijovskiGábor ReuterGerhard FalkenhorstM. LynchMateja Poljšak-prijateljErwin DuizerA. Hocevar GromHarry VennemaBlenda BöttigerLeena MaunulaLinda VerhoefJohn P. Harrissubject
Veterinary medicineEpidemiologyMESH : Genotypemedicine.disease_causeDisease OutbreaksFoodborne DiseasesMESH: GenotypeEpidemiologyMedicineMESH: Disease OutbreaksMESH: Caliciviridae InfectionsCaliciviridae Infections0303 health sciencesFood poisoningbiologyTransmission (medicine)Incidence (epidemiology)Gastroenteritis3. Good healthEuropeMESH : GastroenteritisDisease Notification[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/VirologyMESH : Caliciviridae InfectionsMicrobiology (medical)MESH: Norovirusmedicine.medical_specialtyGenotypeMESH: Disease NotificationMESH : Europe[ SDV.MP.VIR ] Life Sciences [q-bio]/Microbiology and Parasitology/VirologyMESH: Multivariate Analysis03 medical and health sciencesEnvironmental healthHumansMESH : Disease OutbreaksMESH : Foodborne DiseasesMESH: Foodborne DiseasesDisease Notification030304 developmental biologyMESH: Humans030306 microbiologybusiness.industryMESH : NorovirusNorovirusMESH : HumansOutbreakMESH : Multivariate AnalysisMESH : Disease Notificationmedicine.diseasebiology.organism_classificationCaliciviridaeMESH: GastroenteritisMultivariate AnalysisNorovirusMESH: Europebusinessdescription
ABSTRACT The Foodborne Viruses in Europe network has developed integrated epidemiological and virological outbreak reporting with aggregation and sharing of data through a joint database. We analyzed data from reported outbreaks of norovirus (NoV)-caused gastroenteritis from 13 European countries (July 2001 to July 2006) for trends in time and indications of different epidemiology of genotypes and variants. Of the 13 countries participating in this surveillance network, 11 were capable of collecting integrated epidemiological and virological surveillance data and 10 countries reported outbreaks throughout the entire period. Large differences in the numbers and rates of reported outbreaks per country were observed, reflecting the differences in the focus and coverage of national surveillance systems. GII.4 strains predominated throughout the 5-year surveillance period, but the proportion of outbreaks associated with GII.4 rose remarkably during years in which NoV activity was particularly high. Spring and summer peaks indicated the emergence of genetically distinct variants within GII.4 across Europe and were followed by increased NoV activity during the 2002-2003 and 2004-2005 winter seasons. GII.4 viruses predominated in health care settings and in person-to-person transmission. The consecutive emergence of new GII.4 variants is highly indicative of immune-driven selection. Their predominance in health care settings suggests properties that facilitate transmission in settings with a high concentration of people such as higher virus loads in excreta or a higher incidence of vomiting. Understanding the mechanisms driving the changes in epidemiology and clinical impact of these rapidly evolving RNA viruses is essential to design effective intervention and prevention measures.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-09-01 |