Search results for "Mesh"
showing 10 items of 885 documents
Influence of geometric variations on LV activation times: A study on an atlas-based virtual population
2010
We present the fully automated pipeline we have developed to obtain electrophysiological simulations of the heart on a large atlas-based virtual population. This virtual population was generated from a statistical model of left ventricular geometry, represented by a surface model. Correspondence between tetrahedralized volumetric meshes was obtained using Thin Plate Spline warps. Simulations are based on the fast solving of Eikonal equations, and stimulation sites correspond to physiological activation. We report variations of total activation time introduced by geometry, as well as variations in the location of last activation. The obtained results suggest that the total activation time ha…
Sensitivity analysis of mesh warping and subsampling strategies for generating large scale electrophysiological simulation data
2011
The analysis of large-scale simulation data from virtual populations can be effective to gain computational insight into disease mechanisms and treatment strategies, which can serve for generating hypotheses for and focusing subsequent clinical trials. This can be instrumental in shortening the critical path in medical product development and more cost-effective clinical trials. A previously published pipeline established point correspondence among volumetric meshes to enable meaningful statistics on cardiac electrophysiological simulations on the anatomical distribution of a large-scale virtual population. Thin Plate Splines (TPS), derived from surface deformations, were used to warp a tem…
Reliable computation and local mesh adaptivity in limit analysis
2019
The contribution is devoted to computations of the limit load for a perfectly plastic model with the von Mises yield criterion. The limit factor of a prescribed load is defined by a specific variational problem, the so-called limit analysis problem. This problem is solved in terms of deformation fields by a penalization, the finite element and the semismooth Newton methods. From the numerical solution, we derive a guaranteed upper bound of the limit factor. To achieve more accurate results, a local mesh adaptivity is used. peerReviewed
A role for peroxisome proliferator-activated receptor gamma in resveratrol-induced colon cancer cell apoptosis.
2014
Scope Resveratrol may function as a chemopreventive agent. A recent clinical study demonstrates a reduction in tumor cell proliferation in colorectal patients receiving repeated oral ingestion of resveratrol. However, gaps remain in our knowledge of the molecular mechanisms by which resveratrol exerts its chemopreventive effect. We have previously demonstrated that resveratrol induces apoptosis in colon cancer cells and that resveratrol can sensitize chemoresistant colon cancer cells to various drugs. Based on its ability to activate peroxisome proliferator-activated receptor gamma (PPARγ) in colon cancer cells, we sought to determine the implication of this nuclear transcription factor in …
Mechanisms involved in lipid accumulation and apoptosis induced by 1-nitropyrene in Hepa1c1c7 cells
2011
International audience; 1-Nitropyrene (1-NP) is a nitro-polycyclic aromatic hydrocarbon (nitro-PAH) present in diesel exhaust and bound to particular matter in urban air. We show that 1-NP and the referent PAH benzo(a)pyrene (BP) induce apoptosis and a lipid accumulation dependent on cytochrome P450 1A1-metabolites in mouse hepatoma cells, whereas 1-amino-pyrene had no effect. The caspase inhibitor, N-benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone (Z-VAD-fmk), inhibits 1-NP-induced apoptosis, but failed to alter 1-NP-triggered lipid accumulation determined by Nile red staining. We further show that cholesterol and fatty acid contents are modified after nitro-PAH exposure and that 1…
An implicit mesh discontinuous Galerkin formulation for higher-order plate theories
2019
In this work, a discontinuous Galerkin formulation for higher-order plate theories is presented. The starting point of the formulation is the strong form of the governing equations, which are derived in the context of the Generalized Unified Formulation and the Equivalent Single Layer approach from the Principle of Virtual Displacements. To express the problem within the discontinuous Galerkin framework, an auxiliary flux variable is introduced and the governing equations are rewritten as a system of first-order partial differential equations, which are weakly stated over each mesh element. The link among neighboring mesh elements is then retrieved by introducing suitably defined numerical …
Development and Psychometric Validation of the Brief Nurses' Practice Environment Scale and Its Relation to Burnout Syndrome and Job Satisfaction: A …
2020
Introduction: Nursing environment is a vast concept that traditionally has included a wide range of job characteristics and has been related to burnout and job satisfaction. For its measurement, the Practice Environment Scale of the Nursing Work Index (PESNWI) stands out. However, shorter instruments are needed. The purpose of the study is to develop and test the Brief Nurses' Practice Environment (BNPE) Scale.Methods: The BNPE Scale was developed and tested in a sample of 210 Spanish nurses (data collection 2018).Results: Cronbach's alpha was 0.702. The confirmatory factor analysis (CFA), with an excellent fit, offered evidence of internal validity. Regarding validity, the BNPE Scale predi…
A Curvature Based Method for Blind Mesh Visual Quality Assessment Using a General Regression Neural Network
2016
International audience; No-reference quality assessment is a challenging issue due to the non-existence of any information related to the reference and the unknown distortion type. The main goal is to design a computational method to objectively predict the human perceived quality of a distorted mesh and deal with the practical situation when the reference is not available. In this work, we design a no reference method that relies on the general regression neural network (GRNN). Our network is trained using the mean curvature which is an important perceptual feature representing the visual aspect of a 3D mesh. Relatively to the human subjective scores, the trained network successfully asses…
The FLO Diffusive 1D-2D Model for Simulation of River Flooding
2016
An integrated 1D-2D model for the solution of the diffusive approximation of the shallow water equations, named FLO, is proposed in the present paper. Governing equations are solved using the MArching in Space and Time (MAST) approach. The 2D floodplain domain is discretized using a triangular mesh, and standard river sections are used for modeling 1D flow inside the section width occurring with low or standard discharges. 1D elements, inside the 1D domain, are quadrilaterals bounded by the trace of two consecutive sections and by the sides connecting their extreme points. The water level is assumed to vary linearly inside each quadrilateral along the flow direction, but to remain constant …
24S-hydroxycholesterol and cholesterol-24S-hydroxylase (CYP46A1) in the retina: from cholesterol homeostasis to pathophysiology of glaucoma.
2011
http://www.sciencedirect.com/; International audience; Free cholesterol is the predominant form of cholesterol in the neural retina. The vertebrate neural retina exhibits its own capacity to synthesize cholesterol and meets its demand also by taking it from the circulation. Defects in cholesterol synthesis and trafficking in the neural retina has detrimental consequences on its structure and function, highlighting the crucial importance of maintaining cholesterol homeostasis in the retina. Our purpose was to give a review on the functioning of the retina, the role of cholesterol and cholesterol metabolism therein, with special emphasis on cholesterol-24S-hydroxylase (CYP46A1). Similar to th…