Search results for "Meta-"
showing 10 items of 1069 documents
Systematic review and meta-analysis of the efficacy and safety of minocycline in schizophrenia
2017
ObjectiveOur aim was to perform an updated systematic review and meta-analysis on the efficacy and safety of adjunctive minocycline as a treatment of schizophrenia.MethodsWe conducted a PubMed/Scopus database search from inception to 3 February 2016 for randomized, placebo-controlled trials (RCTs), open non-randomized studies, and case reports/series evaluating minocycline in patients with schizophrenia. Random-effects meta-analysis of positive, negative, depressive, and cognitive symptom rating scales, discontinuation and adverse effects rates calculating standardized mean difference (SMD), and risk ratios±95% confidence intervals (CI95%) were calculated.ResultsSix RCTs were eligible (mino…
Meta-analyysin ja metaregression soveltaminen fyysistä aktiivisuutta mittaaviin tutkimuksiin
2017
Tieteellistä tietoa tuotetaan jatkuvasti lisää, mutta sen yhdistäminen aiempaan tietämykseen ei ole ongelmatonta. Tilastotieteellisesti tätä pulmaa lähestytään meta-analyysin ja metaregression avulla. Meta-analyysi on systemaattisessa kirjallisuuskatsauksessa kerätyn aineiston tilastollista yhteenvetoa; useista estimaateista luottamusväleineen muodostetaan yksi keskimääräinen estimaatti ja sen luottamusväli. Huomattavaa on, että meta-analyysin aineisto on eräänlainen aineistojen aineisto; havaintoyksiköitä eivät ole tutkimuksiin osallistuvat koehenkilöt vaan itse tutkimukset. Metaregressio on meta-analyysiä, jossa yhteenveto tehdään hyödyntämällä tutkimusten taustamuuttujia eli kovariaattej…
A systematic review and meta-analysis of the benefits of school-based, peer-led interventions for leaders
2022
The aim of our systematic review and meta-analysis was to quantitatively synthesise the effects of school-based peer-led interventions on leaders’ academic, psychosocial, behavioural, and physical outcomes. Eligible studies were those that: (i) evaluated a school-based peer-led intervention using an experimental or quasi-experimental study design, (ii) included an age-matched control or comparison group, and (iii) evaluated the impact of the intervention on one or more leader outcomes. Medline, Sportdiscus, Psychinfo, Embase, and Scopus online databases were searched on the 24th of October, 2022 which yielded 13,572 results, with 31 included in the narrative synthesis and 12 in the meta-ana…
Heart rate variability and self-control–A meta-analysis
2016
We read the commentary on our meta-analysis with great interest and we greatly appreciate that the authors developed suggestions for further research on heart rate variability (HRV) and self-control. While we mostly support these suggestions, we believe that it is necessary to clarify some points raised with respect to our meta-analysis. The first point brought up by the authors of the commentary is the focus of our meta-analysis on HRV instead of vagal tone and the inclusion of studies using the standard deviation of RR intervals (SDNN). They argue that only vagal tone and HRV metrics reflecting vagal tone are expected to be linked to self-control according to both the Neurovisceral Integr…
Large-scale genotyping identifies 41 new loci associated with breast cancer risk
2013
Journal article Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ~9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC). The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborat…
Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry
2009
We conducted meta-analyses of genome-wide association studies (GWAS) for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a novel locus for AF (ZFHX3, rs2106261, risk ratio [RR]=1.19; P=2.3×10−7), an association that was replicated in the German AF Network (odds ratio=1.44; P=1.6×10−11). Combining the discovery and replication results, rs2106261 was significantly associated with AF (RR=1.25; P=1.8×10−15).
ISTehnology – integrated Approach to IS Development and Benefits of its Using
2011
The system ISTechnology and benefits of its usage are analyzed in the paper. ISTechnology provides an integrated approach to business modeling and development of information systems. The system consists of a meta-model and applications. The meta-model enables defining of a platform independent business model of the organization. The applications provide the definition and interpretation of the business model. Interpretation of the business model provides functionality of the information system in the selected platform. The lessons learned confirm that the development and maintenance cost of information systems can be significantly reduced by use of the ISTechnology. The paper describes addi…
Prevention of injuries among youth team sports : the role of decreased movement control as a risk factor
2017
Good movement control is essential in team sports that require fast-paced running, pivoting, jumping and landing. Alterations in dynamic neuromuscular control may cause significant stress on the musculoskeletal system, and increase the risk of both acute and overuse injuries. The purpose of this dissertation was to investigate the effectiveness of interventions to prevent sports injuries, the incidence and severity of overuse injuries, and the role of decreased movement control as a risk factor for future injuries in young team sports athletes. The study methods included a systematic literature review and meta-analysis of randomized controlled trials, a retrospective epidemiological investi…
A Proposal of Process Fragment Definition and Documentation
2012
This paper focuses on the field of Situational Method Engineering (SME) for the construction of agent-oriented design processes. Whatever SME approach a method designer wants to use, he has to manage two main elements: the (method or process) fragment and the repository where it is stored. Specific fragment definition and documentation are fundamental during these activities, for new process composition, and for the consequent system design activities. This paper aims at illustrating a proposal of fragment definition and documentation. This proposal is aimed to be an input for the IEEE FIPA Design Process Documentation and Fragmentation working group and, as regards our own research work, t…
Crystal structure and Hirshfeld surface analysis of [N(CH3)4][2,2′-Fe(1,7-closo-C2B9H11)2]
2017
Abstract This work investigates the meta -ferrabis(dicarbollide) anion that was isolated as salt of tetramethylammonium. The structure of the obtained crystal consisted of discrete [2,2′-Fe(1,7- closo -C 2 B 9 H 11 ) 2 ] − anions and disordered [N(CH 3 ) 4 ] + cations. The anion had a considerable chemical stability ensured by ionic and Van der Waals interactions. Thus, Hirshfeld surfaces and fingerprint plot were used to visualize, explore, and quantify intermolecular interactions in the crystal lattice of the title compound. This investigation proved that close contacts were dominated by H⋯H interactions.