Search results for "Metas"

Support vector machine classification of brain metastasis and radiation necrosis based on texture analysis in MRI

2015

Purpose To develop a classification model using texture features and support vector machine in contrast-enhanced T1-weighted images to differentiate between brain metastasis and radiation necrosis. Methods Texture features were extracted from 115 lesions: 32 of them previously diagnosed as radiation necrosis, 23 as radiation-treated metastasis and 60 untreated metastases; including a total of 179 features derived from six texture analysis methods. A feature selection technique based on support vector machine was used to obtain a subset of features that provide optimal performance. Results The highest classification accuracy evaluated over test sets was achieved with a subset of ten features…

C-myc mRNA Expression in Epithelial Ovarian Carcinomas in Relation to Estrogen Receptor Status, Metastatic Spread, Survival Time, FIGO Stage, and His…

1998

Recently, it has been suggested that c-myc expression might correlate with estrogen receptor (ER) status and metastatic spread in ovarian cancer. In this study, expression of c-myc mRNA in 90 epithelial ovarian carcinomas was determined using the S1 nuclease protection assay. Expression of c-myc mRNA was detectable in 27 of 90 tumors. There was no significant association between c-myc mRNA expression and metastatic spread, survival time, FIGO stage, or histologic grade and type. C-myc mRNA was expressed in 45% of ER-positive tumors but only 24% of ER-negative tumors (p = 0.094; Fisher's exact test). Similarly, 44% of progesterone receptor (PR)-positive and 23% of PR-negative tumors expresse…

89 Zr-Immuno-Positron Emission Tomography in Oncology: State-of-the-Art 89 Zr Radiochemistry

2017

Contains fulltext : 181624.pdf (Publisher’s version ) (Open Access) Immuno-positron emission tomography (immunoPET) with (89)Zr-labeled antibodies has shown great potential in cancer imaging. It can provide important information about the pharmacokinetics and tumor-targeting properties of monoclonal antibodies and may help in anticipating on toxicity. Furthermore, it allows accurate dose planning for individualized radioimmunotherapy and may aid in patient selection and early-response monitoring for targeted therapies. The most commonly used chelator for (89)Zr is desferrioxamine (DFO). Preclinical studies have shown that DFO is not an ideal chelator because the (89)Zr-DFO complex is partly…

Metastatic Renal Cell Carcinoma to Submandibular Gland: A Rare Occurrence

2015

Approximately 20-30% of patients affected by renal cell carcinoma (RCC) present with metastatic disease, and 20% to 40% undergoing nephrectomy for clinically localized disease will develop metastases. A 53 years old female patient developed a left submandibular swelling. Four years before she experienced a left radical nephrectomy for a clear cell tumor and two years later right kidney was removed for a cancer having the same histologic subtype. In that circumstance duodenal pancreasectomy was required for infiltration of pancreatic gland. A sialoadenectomy has been performed and pathology demonstrated an intraglandular neoplasm with characteristics of a clear renal cell carcinoma. Although…

Discordance rate of HER2 status in primary breast carcinomas versus synchronous axillary lymph node metastases: a multicenter retrospective investiga…

2014

Antonio Ieni,1 Valeria Barresi,1 Rosario Caltabiano,2 Anna Maria Cascone,3 Rachele Del Sordo,4 Daniela Cabibi,5 Pio Zeppa,3 Salvatore Lanzafame,2 Angelo Sidoni,4 Vito Franco,5 Giovanni Tuccari1 1Department of Human Pathology Gaetano Barresi, Section of Anatomic Pathology, University of Messina, Messina, 2Department GF Ingrassia, Section of Anatomic Pathology, University of Catania, Catania, 3Department of Medicine and Surgery, University of Salerno, Salerno, 4Institute of Pathologic Anatomy and Histology, Division of Cancer Research, University of Perugia, Perugia, 5Department of Human Pathology, Section of Anatomic Pathology, University of Palermo, Palermo, Italy Background: Human epiderma…

A qualitative meta-synthesis of patients' experiences of intra- and inter-hospital transitions

2013

Aim. To aggregate, interpret and synthesize findings from qualitative studies of patients’ experiences on being transferred/in transition from one hospital to another or from one ward to another. Background. Studies about patients’ experiences of transfer focused on concepts such as transfer stress, transfer anxiety, and translocation syndrome; however, a metasynthesis on experiences of transition across different patient populations was lacking. Design. The meta-synthesis approach was based on the guidelines by Sandelowski and Barroso. Data source. Six electronic databases were searched for articles published between the years 1999-2011, based on the target phenomenon: patients’ experience…

Fostering creative thinking : the role of primary teachers

2014

Τα τελευταία χρόνια παρατηρείται μια αυξανόμενη απαίτηση για δημιουργικότητα σε όλους τους τομείς της ανθρώπινης δραστηριότητας. Η πρωτοβάθμια εκπαίδευση πασχίζει να συμβαδίσει με τις νέες κοινωνικοοικονομικές ανάγκες και να προετοιμάσει τους δημιουργικούς πολίτες του μέλλοντος. Αν και οι εκπαιδευτικοί της πρωτοβάθμιας εκπαίδευσης παίζουν καθοριστικό ρόλο, άλλοτε θετικό και άλλοτε αρνητικό, στην καλλιέργεια της δημιουργικότητας των μαθητών, λίγες έρευνες έχουν διεξαχθεί σχετικά με τη συμβολή τους στην καλλιέργεια της δημιουργικής σκέψης των μαθητών και τις απόψεις τους για το θέμα αυτό. Η θεμελιωμένη γνώση (situated knowledge) των Ελλήνων εκπαιδευτικών πρωτοβάθμιας εκπαίδευσης και η εμπειρί…

Pembrolizumab-induced lichen planus pemphigoides in a patient with metastatic melanoma

2017

Antimetastatic activity of adriamycin in combinations with proteinase inhibitors in mice

1990

The antimetastatic activity of adriamycin in combination with proteinase inhibitors was investigated in mice bearing the metastatic tumors L1210 leukemia, Lewis lung carcinoma or M5076 sarcoma. Leupeptin, a cathepsin B inhibitor, when administered as a single agent was devoid of antimetastatic activity but some therapeutic activity was noted in mice with Lewis lung carcinoma when the agent was administered in combination with adriamysin. Pepstatin A, a cathepsin D inhibitor, had no effect as a single agent in mice with L1210 leukemia but displayed some antimetastatic activity in mice with Lewis lung carcinoma. In mice with M5076 sarcoma the combination of pepstatin A and adriamycin resulted…

Clima motivacional, metas de logro de aproximación y evitación y bienestar en futbolistas cadetes

2021

Basado en la teoría de las metas de logro (modelo dicotómico, Nicholls, 1989; y modelo 2 x 2, Elliot y McGregor, 2001), se exploró un modelo en el que se analizaban las relaciones hipotetizadas entre el clima motivacional percibido, la competencia percibida, las metas de maestría y resultado (aproximación y evitación), e indicadores positivos de bienestar (satisfacción con la vida y autoestima). Participaron 370 jóvenes varones jugadores de fútbol entre los 12 y los 16 años (M = 14,77). Los resultados mostraron una asociación positiva entre la percepción de un clima de implicación en la tarea y las orientaciones a la maestría (aproximación y evitación), y entre la percepción de un clima de …