Search results for "Methanol"
showing 10 items of 1026 documents
Cardiovascular effects of the methanol and dichloromethanol extracts fromTeucrium flavum L.
1998
The effects on arterial blood pressure and heart rate of the methanol and dichloromethanol extracts from Teucrium flavumL. were analysed in urethane anaesthetized rats. Mean arterial blood pressure was significantly reduced by the i.v. administration of both extracts to normotensive rats. The methanol extract also induced a decrease in the heart rate, while the dichloromethanol extract lacked any effect on this parameter. © 1998 John Wiley & Sons, Ltd.
Dimerization of (+)-Lysergic Acid Esters
2007
Dimer isomer mixtures, characterized by a bridgehead C8-C8' bond, (6a-7a; 6b-7b) were obtained from (+)-lysergic acid methyl or ethyl ester (1b; 1c) in a solution of methanol or ethanol. The isomers were separated, and their structures were determined by detailed NMR measurements and X-ray analysis. Density functional theory was applied to provide insight into the reaction mechanism. Based on an extended examination and the theoretical calculations, a plausible reaction sequence leading to dimers is also presented. The proposed mechanism has been verified by detecting the formation of the superoxide radical anion (O 2 * -).
Evaluation of the analgesic action of different fractions from the methanol extract of Teucrium buxifolium L
1998
Different fractions (F-2, F-3, F-5) of the methanol extract from Teucrium buxifolium L. have been tested for their analgesic activity in mice. All of them exhibited peripheral analgesic activity except F-3, Fraction F-5 had the strongest effect and was subjected to a second re-extraction. The subfractions obtained (F-5/3 and F-5/8) exhibited a similar activity to that observed with the whole fraction. (C) 1998 John Wiley & Sons, Ltd.
Effects on Arterial Blood Pressure of Methanol and Dichloromethanol Extracts fromJuniperus oxycedrus L.
1997
The present study analysed the effect of the methanol and dichloromethanol extracts from Juniperus oxycedrus on arterial blood pressure in anaesthetized rats. The arterial blood pressure of normotensive rats was significantly reduced by the i.v. administration of both extracts. The hypotensive effect of these extracts was independent of the adrenergic system. These results may explain the vasorelaxing actions observed in other Juniperus species.
Effects on Arterial Blood Pressure of the Methanol and Dichloromethanol Extracts from Schinus molle L. in Rats
1996
The effects on arterial blood pressure of the methanol and dichloromethanol extracts from Schinus molle L. were analysed in urethane anaesthetized rats. In normotensive rats, the mean arterial blood pressure was significantly reduced by the i.v. administration of both extracts. The dichloromethanol extract inhibited the effects of noradrenaline on arterial blood pressure in the anaesthetized rat and it reduced the maximal contractile effect (Emax) induced by noradrenaline on rat vas deferens in the organ bath. However, the methanol extract did not modify the effects of noradrenaline in the evaluated tests.
Evaluation of the analgesic and CNS actions of different fractions from the methanol extract ofTeucrium flavum L.
1998
Different fractions (F.1, F-3, F-5, F-6, F-7, F-8) of the methanol extract from Teucrium flavum L. have been tested for their central nervous system and analgesic activities at a dose of 200 mg/kg. Fractions F-1, F-3 and F-7 showed CNS depressant activity, while fractions F-5, F-6 and F-8 had a slight CNS stimulant action. Fractions F-5, F-6, F-7 and F-8 were responsible for the analgesic activity of the extract.
Effects on arterial blood pressure of the methanol extracts from differentTeucriumspecies
1997
Methanol extracts of the leaves and stems of two Teucrium species (T. pumillum L. and T. buxifolium L.) have been tested for their effects on resting arterial blood pressure. Both T. pumillum L. and T. buxifolium L. extracts reduced mean arterial blood pressure in a dose dependent manner when administered i.v. to urethane anaesthetized normotensive rats. © 1997 John Wiley & Sons, Ltd.
Cardiovascular effects of the methanol and dichloromethanol extracts fromMentha suaveolensEhrh.
2001
Methanol and dichloromethanol extracts of the leaves and stems of Mentha suaveolens Ehrh. have been tested for their effects on resting arterial blood pressure, heart rate and noradrenaline induced hypertension. Both extracts administered by i.v. bolus to urethane anaesthetized normotensive rats reduced the mean arterial blood pressure and heart rate, while only the dichloromethanol extract prevented the noradrenaline induced hypertension.
Organic solvents vapor pressure and relative humidity effects on the phase transition rate of α and β forms of tegafur.
2011
The objective of this work was to investigate the relative humidity (RH) and solvent vapor pressure effects on the phase transition dynamics between tegafur polymorphic forms that do not form hydrates and solvates. The commercially available α and β modifications of 5-fluoro-1-(tetrahydro-2-furyl)-uracil, known as the antitumor agent tegafur, were used as model materials for this study. While investigating the phase transitions of α and β tegafur under various partial pressures of methanol, n-propanol, n-butanol, and water vapor, it was determined that the phase transition rate increased in the presence of solvent vapors, even though no solvates were formed. By increasing the relative air h…
Photoinduced functionalization of diterpenes: photochemical behaviour of grandifloric acid in methanol and acetonitrile
2004
Abstract Irradiation of grandiflorolic acid (11) at λ=254 nm in acetonitrile gave the two epimers 13 and 14 through a photodecarboxylation reaction of the carboxylic group on C-4. Irradiation of compound 11 in methanol at λ=254 nm provided the transformation of the C-20 angular methyl into a carbomethoxymethyl group. In this case, unlike compounds 13 and 14, only one of the two possible isomers (15) was obtained (equatorial methyl at C-4). A mechanistic approach of this reaction in discussed, and the role of mutual stereochemistry between C-20 methyl and C-19 carboxylic group in determining the course of the reaction is pointed out.