Search results for "Mg"
showing 10 items of 492 documents
Coordinated Sumoylation and Ubiquitination Modulate EGF Induced EGR1 Expression and Stability
2011
Background Human early growth response-1 (EGR1) is a member of the zing-finger family of transcription factors induced by a range of molecular and environmental stimuli including epidermal growth factor (EGF). In a recently published paper we demonstrated that integrin/EGFR cross-talk was required for Egr1 expression through activation of the Erk1/2 and PI3K/Akt/Forkhead pathways. EGR1 activity and stability can be influenced by many different post-translational modifications such as acetylation, phosphorylation, ubiquitination and the recently discovered sumoylation. The aim of this work was to assess the influence of sumoylation on EGF induced Egr1 expression and/or stability. Methods We …
Proteasome comprising a beta1 inducible subunit acts as a negative regulator of NADPH oxidase during elicitation of plant defense reactions.
2005
Elicitation of defense reactions in tobacco by cryptogein, triggered a production of active oxygen species (AOS) via the NADPH oxidase, NtrbohD, and an accumulation of beta1din, a defense induced beta-type subunit of 20S proteasome. The proteasome inhibitor, MG132, stimulated this AOS production. Tobacco cells transformed with sense constructs of beta1din showed an inhibition of the AOS production following elicitin treatment, whereas the antisense transformed cells showed a strongly enhanced AOS production. In cells transformed with sense construct of beta1din, the NtrbohD transcripts failed to be induced by cryptogein as observed in control and antisense transformed cells. Conversely, in …
Smooth surjections and surjective restrictions
2017
Given a surjective mapping $f : E \to F$ between Banach spaces, we investigate the existence of a subspace $G$ of $E$, with the same density character as $F$, such that the restriction of $f$ to $G$ remains surjective. We obtain a positive answer whenever $f$ is continuous and uniformly open. In the smooth case, we deduce a positive answer when $f$ is a $C^1$-smooth surjection whose set of critical values is countable. Finally we show that, when $f$ takes values in the Euclidean space $\mathbb R^n$, in order to obtain this result it is not sufficient to assume that the set of critical values of $f$ has zero-measure.
Trace and density results on regular trees
2019
We give characterizations for the existence of traces for first order Sobolev spaces defined on regular trees.
The HMGA1 protoncogene frequently deregulated in cancer is a transcriptional target of E2F1
2011
Reactivation of the HMGA1 protoncogene is very frequent in human cancer, but still very little is known on the molecular mechanisms leading to this event. Prompted by the finding of putative E2F binding sites in the human HMGA1 promoter and by the frequent deregulation of the RB/E2F1 pathway in human carcinogenesis, we investigated whether E2F1 might contribute to the regulation of HMGA1 gene expression. Here we report that E2F1 induces HMGA1 by interacting with a 193bp region of the HMGA1 promoter containing an E2F binding site surrounded by three putative Sp1 binding sites. Both gain and loss of function experiments indicate that Sp1 functionally interacts with E2F1 to promote HMGA1 expre…
African trypanosomes expressing multiple VSGs are rapidly eliminated by the host immune system
2019
Significance Many parasites escape the host immune system by undergoing antigenic variation, a process in which surface antigens are regularly shed and replaced by new ones. Trypanosoma brucei employs multiple sophisticated molecular mechanisms to ensure the expression of a homogeneous VSG coat. We generated a mutant parasite that expresses multiple distinct VSGs and studied the consequences of having a multi-VSG coat during an infection. We showed that expression of multiple VSGs makes the parasites more vulnerable to the immune response, which can now control the trypanosomes from the onset of the infection, allowing most mice to survive. In the future, trypanosome infections may be treat…
Weak chord-arc curves and double-dome quasisymmetric spheres
2014
Let $\Omega$ be a planar Jordan domain and $\alpha>0$. We consider double-dome-like surfaces $\Sigma(\Omega,t^{\alpha})$ over $\overline{\Omega}$ where the height of the surface over any point $x\in\overline{\Omega}$ equals $\text{dist}(x,\partial\Omega)^{\alpha}$. We identify the necessary and sufficient conditions in terms of $\Omega$ and $\alpha$ so that these surfaces are quasisymmetric to $\mathbb{S}^2$ and we show that $\Sigma(\Omega,t^{\alpha})$ is quasisymmetric to the unit sphere $\mathbb{S}^2$ if and only if it is linearly locally connected and Ahlfors $2$-regular.
Rescaling principle for isolated essential singularities of quasiregular mappings
2012
We establish a rescaling theorem for isolated essential singularities of quasiregular mappings. As a consequence we show that the class of closed manifolds receiving a quasiregular mapping from a punctured unit ball with an essential singularity at the origin is exactly the class of closed quasiregularly elliptic manifolds, that is, closed manifolds receiving a non-constant quasiregular mapping from a Euclidean space.
Study with surface electromyography, borg scale and rom upper trapezius, deltoid of the three portions (clavicular, acromial, spinal) and the latissi…
2017
The pathologies located at shoulder can be caused by misuse or continued implementation of a sporting practice or physical activity. These pathologies are second position in the ranking of Traumatologics and Orthopedic Clinicals (Windt, Koes, De Jong & Bouter, 1995). Shoulder’s muscle injuries can occur when the arm is in a position that exceeds normal, this fact is repeated in sport, may be the repetition of the hand signal of the inductor problem (Kapandji, 2006). Given the importance of muscle function of the shoulder joint, along the existing boom of new techniques in the specific muscle activation has been carried out an experimental study using a " Test neuro proprioceptive response "…
Human Papilloma Virus-Dependent HMGA1 Expression Is a Relevant Step in Cervical Carcinogenesis
2008
HMGA1 is a member of a small family of architectural transcription factors involved in the coordinate assembly of multiprotein complexes referred to as enhanceosomes. In addition to their role in cell proliferation, differentiation, and development, high-mobility group proteins of the A type (HMGA) family members behave as transforming protoncogenes either in vitro or in animal models. Recent reports indicated that HMGA1 might counteract p53 pathway and provided an interesting hint on the mechanisms determining HMGA's transforming potential. HMGA1 expression is deregulated in a very large array of human tumors, including cervical cancer, but very limited information is available on the mole…