Search results for "Mg"
showing 10 items of 492 documents
Latvijas un Zviedrijas attiecības no 1927. līdz 1930. gadam
2022
Bakalaura darbs “Latvijas un Zviedrijas attiecības no 1927. līdz 1930. gadam” analizē valstu politiskās, ekonomiskās attiecības un kultūras sakarus iekšpolitisko, ārpolitisko procesu iespaidā. Mērķis ir raksturot Latvijas un Zviedrijas attiecības Gustava Zemgala prezidentūras laikā kontekstā ar situāciju Baltijas jūras reģionā un Eiropā. Faktori, kā PSRS ietekmes pieaugums, reģiona vienotības trūkums, sūtņa Kārļa Zariņa darbība, iezīmēja jaunu posmu Latvijas – Zviedrijas attiecībās, ko raksturoja pakāpeniska sakaru paplašināšanās, gūstot pilnīgāku izpratni par to nozīmi. Zviedrija vēlējās uzturēt drošību reģionā caur ekonomisko un kultūras sakaru stiprināšanu, Tautu Savienības iesaisti, bet…
Keski-ikäisten ja iäkkäiden naisten ja miesten intensiivisen voimaharjoittelun aiheuttamat muutokset lihasten voimantuotto-ominaisuuksiin, EMG-aktiiv…
2002
A multicenter phase 1 study of solitomab (MT110, AMG 110), a bispecific EpCAM/CD3 T-cell engager (BiTE®) antibody construct, in patients with refract…
2018
ABSTRACT We assessed the tolerability and antitumor activity of solitomab, a bispecific T-cell engager (BiTE®) antibody construct targeting epithelial cell adhesion molecule (EpCAM). Patients with relapsed/refractory solid tumors not amenable to standard therapy received solitomab as continuous IV infusion in a phase 1 dose-escalation study with six different dosing schedules. The primary endpoint was frequency and severity of adverse events (AEs). Secondary endpoints included pharmacokinetics, pharmacodynamics, immunogenicity, and antitumor activity. Sixty-five patients received solitomab at doses between 1 and 96 µg/day for ≥28 days. Fifteen patients had dose-limiting toxicities (DLTs): e…
Neural Adaptations to Strength Training
2018
Scientific study of strength training has revealed numerous physiological mechanisms that contribute to: (1) acute fatigue from a single strength training session and (2) chronic adaptation to repetitive and systematic strength training. Therefore, the purpose of this chapter is initially to discuss potential neural mechanisms that influence force production from the perspective of a single repetition. Thereafter, the chapter will highlight scientific evidence for candidate neural mechanisms that acutely limit force production during a single strength training session and long-term adaptations caused by strength training. For some of these potential neural mechanisms, there is strong scient…
Lindes un Birsgalles pagasta peenahkami darbi un klausischana [Lindes un Birzgales pagasta pienākami darbi un klausīšana]
1805
ERNESTA HEMINGVEJA PERSONĪBAS UN STĀSTA ‘’SIRMGALVIS UN JŪRA’’ IEPAZĪŠANA LITERATŪRAS STUNDĀS 12. KLASĒ
2022
Diplomdarba ‘’Ernesta Hemingveja personības un stāsta ‘’Sirmgalvis un jūra’’ iepazīšana literatūras stundās 12. klasē’’ mērķis ir izstrādāt metodiskās sistēmas variantu sekmīgai Ernesta Hemingveja personības un stāsta ‘’Sirmgalvis un jūra’’ iepazīšanai literatūras stundās 12. klasē. Izmantojot pedagoģiskās un metodiskās literatūras analīzi, izstrādāta teorētiskā bāze, kas nepieciešama mācību satura apguvei. Tā aprakstīta 1., 2. un 3. nodaļā. Veicot skolēnu anketēšanu un pedagoģisko novērošanu, iegūta informācija par 12. klases skolēnu lasīšanas paradumiem un psiholoģisko raksturojumu, kas aprakstīta 4. nodaļā. Piektajā nodaļā raksturota izmēģinājumdarbība un tās rezultātu analīze. Pētījumā …
A remark on two notions of flatness for sets in the Euclidean space
2021
In this note we compare two ways of measuring the $n$-dimensional "flatness" of a set $S\subset \mathbb{R}^d$, where $n\in \mathbb{N}$ and $d>n$. The first one is to consider the classical Reifenberg-flat numbers $\alpha(x,r)$ ($x \in S$, $r>0$), which measure the minimal scaling-invariant Hausdorff distances in $B_r(x)$ between $S$ and $n$-dimensional affine subspaces of $\mathbb{R}^d$. The second is an `intrinsic' approach in which we view the same set $S$ as a metric space (endowed with the induced Euclidean distance). Then we consider numbers ${\sf a}(x,r)$'s, that are the scaling-invariant Gromov-Hausdorff distances between balls centered at $x$ of radius $r$ in $S$ and the $n$-dimensi…
On Limits at Infinity of Weighted Sobolev Functions
2022
We study necessary and sufficient conditions for a Muckenhoupt weight $w \in L^1_{\mathrm{loc}}(\mathbb R^d)$ that yield almost sure existence of radial, and vertical, limits at infinity for Sobolev functions $u \in W^{1,p}_{\mathrm{loc}}(\mathbb R^d,w)$ with a $p$-integrable gradient $|\nabla u|\in L^p(\mathbb R^d,w)$. The question is shown to subtly depend on the sense in which the limit is taken. First, we fully characterize the existence of radial limits. Second, we give essentially sharp sufficient conditions for the existence of vertical limits. In the specific setting of product and radial weights, we give if and only if statements. These generalize and give new proofs for results of…
Two examples related to conical energies
2022
In a recent article we introduced and studied conical energies. We used them to prove three results: a characterization of rectifiable measures, a characterization of sets with big pieces of Lipschitz graphs, and a sufficient condition for boundedness of nice singular integral operators. In this note we give two examples related to sharpness of these results. One of them is due to Joyce and M\"{o}rters, the other is new and could be of independent interest as an example of a relatively ugly set containing big pieces of Lipschitz graphs.
Ruolo citotossico del cannabinoide sintetico WIN55,212-2 in cellule di osteosarcoma MG63: coinvolgimento della proteina SPARC.
Il cannabinoide sintetico WIN 55,212-2 è un potente agonista sintetico del recettore per i cannabinoidi con spiccate potenzialità antitumorali. Gli esperimenti riportati in questa tesi sono stati condotti per delineare gli effetti indotti dal WIN sulla proliferazione, la migrazione e la sensibilizzazione alla morte indotta dalla citochina TRAIL in cellule di osteosarcoma umano MG63. I risultati ottenuti mostrano che il WIN induce un blocco del ciclo cellulare in fase G2/M che è associato all’induzione dei principali markers di ER stress (GRP78, CHOP e TRB3). Nelle cellule trattate abbiamo inoltre osservato la conversione della forma citosolica del marker autofagosomale LC3-I in LC3-II (la f…