Search results for "Micro"

Aislamiento y función de células progenitoras endoteliales de sangre periférica durante la evolución clínica de pacientes con infarto agudo de miocar…

2015

Las células endoteliales (CE) recubren el interior de los vasos sanguíneos constituyendo el endotelio, actualmente considerado un órgano muy activo e implicado en la regulación del tono vascular, el tráfico de células sanguíneas, el equilibrio hemostático, la permeabilidad, la proliferación, la supervivencia, y la respuesta inmunitaria tanto adaptativa como innata. Los factores de riesgo cardiovascular como la hipercolesterolemia, la diabetes y el tabaquismo pueden causar lesiones endoteliales, uno de los principales desencadenantes de la patogénesis en la aterosclerosis, predisponiendo al desarrollo y progresión de enfermedades cardiovasculares. Hoy en día, las enfermedades cardiovasculare…

miMic

2016

miMic, a sonic analogue of paper and pencil is proposed: An augmented microphone for vocal and gestural sonic sketching. Vocalizations are classified and interpreted as instances of sound models, which the user can play with by vocal and gestural control. The physical device is based on a modified microphone, with embedded inertial sensors and buttons. Sound models can be selected by vocal imitations that are automatically classified, and each model is mapped to vocal and gestural features for real-time control. With miMic, the sound designer can explore a vast sonic space and quickly produce expressive sonic sketches, which may be turned into sound prototypes by further adjustment of model…

Sonication-Induced Modification of Carbon Nanotubes: Effect on the Rheological and Thermo-Oxidative Behaviour of Polymer-Based Nanocomposites.

2018

The aim of this work is the investigation of the effect of ultrasound treatment on the structural characteristics of carbon nanotubes (CNTs) and the consequent influence that the shortening induced by sonication exerts on the morphology, rheological behaviour and thermo-oxidative resistance of ultra-high molecular weight polyethylene (UHMWPE)-based nanocomposites. First, CNTs have been subjected to sonication for different time intervals and the performed spectroscopic and morphological analyses reveal that a dramatic decrease of the CNT's original length occurs with increased sonication time. The reduction of the initial length of CNTs strongly affects the nanocomposite rheological behavio…

Advances in Nanoliposomes Production for Ferrous Sulfate Delivery

2020

In this study, a continuous bench scale apparatus based on microfluidic fluid dynamic principles was used in the production of ferrous sulfate-nanoliposomes for pharmaceutical/nutraceutical applications, optimizing their formulation with respect to the products already present on the market. After an evaluation of its fluid dynamic nature, the simil-microfluidic (SMF) apparatus was first used to study the effects of the adopted process parameters on vesicles dimensional features by using ultrasonic energy to enhance liposomes homogenization. Subsequently, iron-nanoliposomes were produced at different weight ratios of ferrous sulfate to the total formulation components (0.06, 0.035, 0.02, an…

Exploiting the Opportunity to Use Plant-Derived Nanoparticles as Delivery Vehicles

2023

The scientific community has become increasingly interested in plant-derived nanoparticles (PDNPs) over the past ten years. Given that they possess all the benefits of a drug carrier, including non-toxicity, low immunogenicity, and a lipid bilayer that protects its content, PDNPs are a viable model for the design of innovative delivery systems. In this review, a summary of the prerequisites for mammalian extracellular vesicles to serve as delivery vehicles will be given. After that, we will concentrate on providing a thorough overview of the studies investigating the interactions of plant-derived nanoparticles with mammalian systems as well as the loading strategies for encapsulating therap…

Development of microfluidics for sorting of carbon nanotubes

2018

Sorting of carbon nanotubes by their chirality is the current bottleneck in the way to their broad employment based on their exceptional electronic and optical properties. Despite the extensive effort, there is no known method, which would result in really pure chirality ensembles. Previously reported sorting protocols result in enrichment rather than in sorting, alter electronic structure, and suffer from low yield. This is mostly due to the statistical approach, where the nanotubes with mixed chiralities are treated as a set. In this thesis, we propose a new sorting technique based on nanotube-by-nanotube compartmelization, characterization, and sorting in a continuously running droplet-b…

Discovery of a new class of sortase a transpeptidase inhibitors to tackle gram-positive pathogens: 2-(2-phenylhydrazinylidene)alkanoic acids and rela…

2016

A FRET-based random screening assay was used to generate hit compounds as sortase A inhibitors that allowed us to identify ethyl 3-oxo-2-(2-phenylhydrazinylidene)butanoate as an example of a new class of sortase A inhibitors. Other analogues were generated by changing the ethoxycarbonyl function for a carboxy, cyano or amide group, or introducing substituents in the phenyl ring of the ester and acid derivatives. The most active derivative found was 3-oxo-2-(2-(3,4dichlorophenyl)hydrazinylidene)butanoic acid (2b), showing an IC50 value of 50 µM. For a preliminary assessment of their antivirulence properties the new derivatives were tested for their antibiofilm activity. The most active compo…

Organizational identity and competition : a study of US semiconductor industry

2017

Organisationaalinen identiteetti ja kilpailu : tutkielma puolijohdeteollisuudesta. Tutkimuksen​ ​tehtävänä​ ​on​ ​selvittää,​ ​miten​ ​kaksi​ ​samalla​ ​puolijohdesektorilla​ ​kilpailevaa yritystä,​ ​Intel​ ​Corporation​ ​ja​ ​Advanced​ ​Micro​ ​Devices,​ ​kuvailee​ ​itseänsä​ ​ja​ ​kenttäänsä suhteessa​ ​kilpailijoihinsa​ ​ja​ ​siten​ ​rakentaa​ ​ja​ ​ylläpitää​ ​organisationaalista​ ​identiteettiään. Tutkimuksen​ ​teoreettisena​ ​näkökulmana​ ​on​ ​tarkastella​ ​markkinoita​ ​sosiaalisesti​ ​rakentuneena kenttänä​ ​jota​ ​kilpailu​ ​ylläpitää.​ ​Analyysimenetelmänä​ ​on​ ​käytetty​ ​koneoppivaa​ ​tekstin mallinnusmenetelmää​ ​nimeltä​ ​Latentti​ ​Dirichlet​ ​Allokaatio​ ​(LDA),​ ​jolla​ ​…

in tema di somministrazione di sostanze alimentari con cariche microbiche superiori ai limiti consentiti (art. 5, lett. c, l. n. 283/1962), nota a Ca…

2012

LACTOBACILLI IN SOURDOUGH FERMENTATION: A REVIEW

2007

Sourdough technology is widely used; it is employed in bread making and for the production of cakes. Sourdough is characterized by a complex microbial ecosystem, mainly represented by lactic acid bacteria and yeasts, whose fermentation confers to the resulting bread its characteristic features such as palatability and high sensory quality. Investigation of the microbial composition of sourdough is relevant in order to determine the potential activities of sourdough microorganisms. This review focuses on the role of the most important group of sourdough fermenting bacteria that consists of lactobacilli; species that belong to the Lactobacillus genus are the main responsible of flavor develop…