Search results for "Microfluidics"
showing 10 items of 121 documents
Liquid-Crystalline Elastomer Fibers Prepared in a Microfluidic Device
2014
Macromol. Chem. Phys. 2/2017
2017
Exploiting Reaction-Diffusion Conditions to Trigger Pathway Complexity in the Growth of a MOF.
2021
Coordination polymers (CPs), including metal–organic frameworks (MOFs), are crystalline materials with promising applications in electronics, magnetism, catalysis, and gas storage/separation. However, the mechanisms and pathways underlying their formation remain largely undisclosed. Herein, we demonstrate that diffusion-controlled mixing of reagents at the very early stages of the crystallization process (i.e., within ≈40 ms), achieved by using continuous-flow microfluidic devices, can be used to enable novel crystallization pathways of a prototypical spin-crossover MOF towards its thermodynamic product. In particular, two distinct and unprecedented nucleation-growth pathways were experimen…
Peptide based biosensors
2018
Abstract This review provides an overview of the various types of (bio)sensors based on peptides for their analytical use, along with significant advances over the last several years in related technologies. So, it will be described: i) principles in biosensing using peptides ii) aspects of fabrication in the perspective of (bio)sensing applications iii) potential of electrochemical, electrochemiluminescence, photoelectrochemical, and optical (bio)sensors for the determination of target analytes within sub-nanomolar range also discussing the main problems in (bio)sensing iv) multiplex electrochemical and optical (bio)sensors, both with and without labels. v) Latest developments in the appli…
Light Scattering as an Easy Tool to Measure Vesicles Weight Concentration
2020
Over the last few decades, liposomes have emerged as promising drug delivery systems and effective membrane models for studying biophysical and biological processes. For all applications, knowing their concentration after preparation is crucial. Thus, the development of methods for easily controlling vesicles concentration would be of great utility. A new assay is presented here, based on a suitable analysis of light scattering intensity from liposome dispersions. The method, tested for extrusion preparations, is precise, easy, fast, non-destructive and uses a tiny amount of sample. Furthermore, the scattering intensity can be measured indifferently at different angles, or even by using the…
Control of the Properties of Micrometer-Sized Actuators from Liquid Crystalline Elastomers Prepared in a Microfluidic Setup
2010
In this article new results on the preparation of monodisperse particles from a liquid crystalline elastomer in a microfluidic setup are presnted. For this, droplets from a liquid crystalline monomer are prepared in a microfluidic device and polymerized while they are flowing inside a microtube. The particles obtained by this method possess an internal orientation, which gives them actuating properties. When they are heated into the isotropic phase of the liquid crystalline material they show a reversible change in shape whereby they change their length in one direction by almost 100%. It is shown how the variation of experimental parameters during their synthesis impacts the properties of…
Infrared microspectroscopy of biochemical response of living cells in microfabricated devices
2010
Abstract First experiments demonstrating the suitability of novel microfabricated fluidic devices for measuring living cells in physiological environment by synchrotron radiation (SR) Fourier Transform Infrared microspectroscopy (μ-FTIR) are presented. The devices were fabricated on CaF 2 windows, using the photoresist XARP 3100/10 to define the liquid cell lay-out. Therefore, the sample holder is transparent to both visible and infrared light, robust, completely recyclable and with a precise spacing. Using prototype devices of thicknesses 9, 5 and 3 μm, we studied the response of the U937 monocytic cell line to mechanical compression. The temporal evolution of the FTIR spectra, characteris…
Microfluidic production of hyaluronic acid derivative microfibers to control drug release
2016
"Available online 4 July 2016"
Direct Writing of Channels for Microfluidics in Silica by MeV Ion Beam Lithography
2011
The lithographic exposure characteristic of amorphous silica (SiO2) was investigated for 6.8 MeV16O3+ions. A programmable proximity aperture lithography (PPAL) technique was used for the ion beam exposure. After exposure, the exposed pattern was developed by selective etching in 4% v/v HF. Here, we report on the development of SiO2in term of the etch depth dependence on the ion fluence. This showed an exponential approach towards a constant asymptotic etch depth with increasing ion fluence. An example of microfluidic channels produced by this technique is demonstrated.
An integrated Tissue Engineering approach to Human Bronchial model: Biodegradable Scaffold and Microfluidics Platform
L’ingegneria tissutale è la combinazione di cellule, materiali e metodi di ingegneria, insieme con opportuni fattori biochimici e fisico-chimici, volta a migliorare o sostituire le funzioni biologiche di tessuti danneggiati [1, 2]. A tal proposito supporti porosi e sistemi microfluidici sono utilizzati per scopi di ingegneria tissutale. Scaffold polimerici biodegradabili sono stati sfruttati come supporti strutturali per rigenerare vari tessuti quali ossa, cartilagini, nervi, legamenti, pelle e fegato. Una geometria porosa aperta con canali interconnessi è un prerequisito per la crescita cellulare ad alta densità e per un trasporto di nutrienti, ossigeno e prodotti di scarto metabolici. …