Search results for "Migration"
showing 10 items of 1709 documents
Bone Metastasis in Renal Cell Carcinoma is Preprogrammed in the Primary Tumor and Caused by AKT and Integrin α5 Signaling
2015
Bone metastasis develops in 30% of all patients with renal cell carcinoma. We elucidated the mechanisms that lead to and predict bone metastasis of renal cell carcinoma.Nine renal cell carcinoma primary cell lines and 30 renal cell carcinoma tissue specimens (normal and tumor tissue) were collected from 3 patients with no metastasis and 10 with lung or bone metastasis within 5 years after nephrectomy. Cell migration was analyzed in a Boyden chamber and proliferation was assessed by bromodeoxyuridine incorporation. Adhesion to fibronectin, and collagen I and IV was determined after cell staining. The expression and/or activity of cellular signaling molecules was quantified by Western blot.Co…
Tracking of Autologous VSOP-Labeled Mesenchymal Stem Cells in the Sheep Brain Using 3.0 T MRI
2012
Assessment of biodistribution and monitoring of cell migration processes in vivo are essential for the safety of novel cell-based therapies for ischemic stroke and early-stage clinical trials, but are mainly lacking investigation in large animal models which are closer to the situation found in human patients. This chapter reports a series of experiments which establish a MRI-sensitive labeling procedure for autologous ovine mesenchymal stem cells (MSC) and the assessment of in vivo and in vitro detection limits of the cells at 3.0 T. Cell migration was monitored after intravenous transplantation following experimental stroke in sheep. Cell detection was feasible at 3.0 T with detection lim…
Hepatitis C virus prevalence and level of intervention required to achieve the WHO targets for elimination in the European Union by 2030: a modelling…
2017
Background Hepatitis C virus (HCV) is a leading cause of liver-related morbidity and mortality worldwide. In the European Union (EU), treatment and cure of HCV with direct-acting antiviral therapies began in 2014. WHO targets are to achieve a 65% reduction in liver-related deaths, a 90% reduction of new viral hepatitis infections, and 90% of patients with viral hepatitis infections being diagnosed by 2030. This study assessed the prevalence of HCV in the EU and the level of intervention required to achieve WHO targets for HCV elimination. Methods We populated country Markov models for the 28 EU countries through a literature search of PubMed and Embase between Jan 1, 2000, and March 31, 201…
Migrazioni e questioni politiche
2020
Il saggio presenta e discute i risultati di una ricerca transnazionale condotta su 16 paesi europei sulla percezione dell'opinione pubblica del nesso transmigrazioni e criminalità. The essay presents and discusses the results of a transnational research conducted on 16 European countries on the public opinion's perception of the link between migration and crime.
Domain wall pinning in ultra-narrow electromigrated break junctions
2014
The study of magnetic domain walls in constrained geometries is an important topic, yet when dealing with extreme nanoscale magnetic systems artefacts can often dominate the measurements and obscure the effects of intrinsic magnetic origin. In this work we study the evolution of domain wall depinning in electromigrated ferromagnetic junctions which are both initially fabricated and subsequently tailored in-situ in clean ultra-high vacuum conditions. Carefully designed Ni(80)Fe(20) (Permalloy) notched half-ring structures are fabricated and investigated as a function of constriction width by tailoring the size of the contact using controlled in-situ electromigration. It is found that the dom…
Domain-wall induced large magnetoresistance effects at zero applied field in ballistic nanocontacts
2013
We determine magnetoresistance effects in stable and clean Permalloy nanocontacts of variable cross section, fabricated by UHV deposition and in situ electromigration. To ascertain the magnetoresistance (MR) effects originating from a magnetic domain wall, we measure the resistance values with and without such a wall at zero applied field. In the ballistic transport regime, the MR ratio reaches up to 50% and exhibits a previously unobserved sign change. Our results can be reproduced by recent atomistic calculations for different atomic configurations of the nanocontact, highlighting the importance of the detailed atomic arrangement for the MR effect. DOI: 10.1103/PhysRevLett.110.067203
Scaling of intrinsic domain wall magneto-resistance with confinement in electromigrated nanocontacts
2018
In this work we study the evolution of intrinsic domain wall magnetoresistance (DWMR) with domain wall confinement. Clean permalloy notched half-ring nanocontacts are fabricated using a special ultra-high vacuum electromigration procedure to tailor the size of the wire in-situ and through the resulting domain wall confinement we tailor the domain wall width from a few tens of nm down to a few nm. Through measurements of the dependence of the resistance with respect to the applied field direction we extract the contribution of a single domain wall to the MR of the device, as a function of the domain wall width in the confining potential at the notch. In this size range, an intrinsic positive…
The skilled migration in North-South direction: the case of the Spanish scientists in Ecuador during the Great Recession (2008-2015)
2020
Durante el periodo de crisis económica que se inició en 2008, Ecuador se convirtió en un destino atractivo para la emigración española cualificada, enmarcada en los nuevos flujos migratorios del Norte-Sur Global. El artículo trata de arrojar luz sobre la emigración española de científicos y científicas a este país a través del análisis de sus trayectorias formativas y profesionales, el papel de las redes científicas, las estrategias migratorias y de inserción laboral en destino, las percepciones sobre el sistema académico ecuatoriano y los planes de futuro. Para ello se ha utilizado una estrategia metodológica cualitativa mediante entrevistas en profundidad a investigadores/as españoles/as …
Création des pôles de compétitivité et salaire des ingénieurs,
2015
En ligne sur http://rei.revues.org/6151; National audience; La création des pôles de compétitivité en France a permis un investissement massif dans des projets de RD dans certains territoires. S'appuyant sur le développement de synergie entre les entreprises, les centres de recherche et les établissements de formation, ces pôles devraient favoriser une politique de ressources humaines propice à l'innovation. Notre recherche propose d'examiner l'effet de la création de ces pôles sur le salaire des diplômés des écoles d'ingénieurs. Une méthode de « différence de différence » avec appariement est utilisée pour comparer les rémunérations des jeunes diplômés avant et après la création des pôles.…
Elusive Migration Systems: Shifting from Transnationalism to Transregionalism
2016
The global financial and economic crisis as well as post-socialist transition means a similar general framework for socioeconomic and spatial development in different countries. Their migration systems react in different ways on such externally caused incidents, even in slightly comparable contexts. Consequences are, among others, increasing migrations and mutual interactions between sending and receiving countries as well as strong linkages of international migrations and internal migratory movements – phenomena we usually refer to as transnationalism. Against this backdrop, the aim of the paper is to stress the “regional element” of transnationalism. Thus, we suggest to broadening the con…