Search results for "Modula"

Biological properties of extracellular vesicles and their physiological functions

2015

The authors wish to thank Dr R Simpson and Dr D Taylor for critical reading of the manuscript and acknowledge the Horizon 2020 European Cooperation in Science and Technology programme and its support of our European Network on Microvesicles and Exosomes in Health & Disease (ME-HaD; BM1202 www.cost.eu/COST_Actions/bmbs/Actions/BM1202). In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity to transfer proteins, lipids and nucleic acids, thereby influencing various physiological and pathological functions of both recipient and parent cells. While intensive invest…

Breast cancer cells exhibit selective modulation induced by different collagen substrates.

2008

During the invasive phase of malignant tumors, neoplastic cells break into the basal lamina and enter in contact with the underlying connective tissue, which concurrently undergoes extensive modifications. The aim of our present minireview is to focus the changes in the collagenous matrix occurring during breast cancer progression and to explore the possible effects of different collagen substrates on breast cancer cell behavior and proteomic modulation.

Online Closed-Loop Real-Time tES-fMRI for Brain Modulation: Feasibility, Noise/Safety and Pilot Study

2021

AbstractRecent studies suggest that transcranial electrical stimulation (tES) can be performed during functional magnetic resonance imaging (fMRI). The novel approach of using concurrent tES-fMRI to modulate and measure targeted brain activity/connectivity may provide unique insights into the causal interactions between the brain neural responses and psychiatric/neurologic signs and symptoms, and importantly, guide the development of new treatments. However, tES stimulation parameters to optimally influence the underlying brain activity in health and disorder may vary with respect to phase, frequency, intensity and electrode’s montage. Here, we delineate how a closed-loop tES-fMRI study of …

Central side-effects of therapies based on CB1 cannabinoid receptor agonists and antagonists: focus on anxiety and depression

2009

Both agonists (e.g. Delta(9)-tetrahydrocannabinol, nabilone) and antagonists (e.g. rimonabant, taranabant) of the cannabinoid type-1 (CB(1)) receptor have been explored as therapeutic agents in diverse fields of medicine such as pain management and obesity with associated metabolic dysregulation, respectively. CB(1) receptors are widely distributed in the central nervous system and are involved in the modulation of emotion, stress and habituation responses, behaviours that are thought to be dysregulated in human psychiatric disorders. Accordingly, CB(1) receptor activation may, in some cases, precipitate episodes of psychosis and panic, while its inhibition may lead to behaviours reminiscen…

Hypoxia-induced dysfunction of rat diaphragm

2004

Contains fulltext : 47331.pdf (Publisher’s version ) (Closed access) Oxidants may play a role in hypoxia-induced respiratory muscle dysfunction. In the present study we hypothesized that hypoxia-induced impairment in diaphragm contractility is associated with elevated peroxynitrite generation. In addition, we hypothesized that strenuous contractility of the diaphragm increases peroxynitrite formation. In vitro force-frequency relationship, isotonic fatigability, and nitrotyrosine levels were assessed under hypoxic (Po(2) approximately 6.5 kPa) and hyperoxic (Po(2) approximately 88.2 kPa) control conditions and also in the presence of authentic peroxynitrite (60 min), ebselen (60 min), and t…

A General Mathematical Model for the Simulation of Common Faults in Three‐ phase Voltage Source Inverters

2013

In the last years the fault problem in power electronics has been more and more investigated both from theoretical and practical point of view. This paper analyzes the problem of faults modeling in a three phase voltage source inverter(VSI) and presents a model of a VSI able to simulate both unfaulty and faulty conditions when one or more devices go broken. In the past the fault problem was faced step by step considering the fault on each single device building a model for each case. The model hereafter presented solves this drawback through the introduction of the concept of the Healthy Device Binary Variable (HDBV) and the more general Healthy Leg Binary Variable (HLBV) showing also as th…

2017

It has been shown in previous papers that classes of (minimal asymmetric) informationally-complete positive operator valued measures (IC-POVMs) in dimension d can be built using the multiparticle Pauli group acting on appropriate fiducial states. The latter states may also be derived starting from the Poincare upper half-plane model H . To do this, one translates the congruence (or non-congruence) subgroups of index d of the modular group into groups of permutation gates, some of the eigenstates of which are the sought fiducials. The structure of some IC-POVMs is found to be intimately related to the Kochen-Specker theorem.

On the Modular Version of Ito’s Theorem on Character Degrees for Groups of Odd Order

1987

One of the most useful theorems in classical representation theory is a result due to N. Ito, which can be stated using the classification of the finite simple groups in the following way.THEOREM (N. Ito, G. Michler). Let Irr (G) be the set of all irreducible complex characters of the finite group G and q be a prime number. Then if and only if G has a normal, abelian Sylow-q-subgroup.

On the Rational Cohomology of Moduli Spaces of Curves with Level Structures

2009

We investigate low degree rational cohomology groups of smooth compactifications of moduli spaces of curves with level structures. In particular, we determine $H^k(\sgbar, \Q)$ for $g \ge 2$ and $k \le 3$, where $\sgbar$ denotes the moduli space of spin curves of genus $g$.

Modular Calabi-Yau threefolds of level eight

2005

In the studies on the modularity conjecture for rigid Calabi-Yau threefolds several examples with the unique level 8 cusp form were constructed. According to the Tate Conjecture correspondences inducing isomorphisms on the middle cohomologies should exist between these varieties. In the paper we construct several examples of such correspondences. In the constructions elliptic fibrations play a crucial role. In fact we show that all but three examples are in some sense built upon two modular curves from the Beauville list.