Search results for "Modula"

Characterization of the immunomodulatory properties of mesenchymal stem cells isolated from Wharton's jelly

2012

Non-classical type I HLAs and B7 costimulators revisited: analysis of expression and immunomodulatory role in undifferentiated and differentiated MSC…

2011

Introduction. Wharton’s jelly (WJ), the main constituent of umbilical cord, emerged as a reliable and uncontroversial source of mesenchymal stem cells (MSC). WJ-MSC show unique ability in crossing lineage borders, therefore being capable to trans-ifferentiate towards mature cytotypes derived from the three germ layers. As other fetal-associated cells, WJ-MSC express several immunomodulatory molecules, essential during the initial phases of human development and for the processes linked to the tolerance of the mother to the semiallogeneic embryo. Very few data are present in literature on the maintenance of the immune privilege of the naïve cells after performing differentiation. Our previou…

Flavonoids against the SARS-CoV-2 induced inflammatory storm

2021

The disease severity of COVID-19, especially in the elderly and patients with co-morbidities, is characterized by hypercytokinemia, an exaggerated immune response associated with an uncontrolled and excessive release of proinflammatory cytokine mediators (cytokine storm). Flavonoids, important secondary metabolites of plants, have long been studied as therapeutic interventions in inflammatory diseases due to their cytokine-modulatory effects. In this review, we discuss the potential role of flavonoids in the modulation of signaling pathways that are crucial for COVID-19 disease, particularly those related to inflammation and immunity. The immunomodulatory ability of flavonoids, carried out …

New frontiers in regenerative medicine in cardiology: the potential of Wharton's jelly mesenchymal stem cells.

2013

Cardiomyopathies are still the first cause of death in the world. The identification of resident stem cells, comprising those derived from sub-endocardial stroma, suggests the possible self regeneration of the heart under autocrine/paracrine modulation in the cardiac microenvironment. Nevertheless, because of the limited in vivo regeneration potential of damaged cardiac tissue, the use of drugs and ultimately cardiac transplantation remain the common treatments of heart diseases and defects. The differentiative potential of embryonic and mesenchymal stem cells (MSCs) derived from different tissues (such as bone marrow and adipose tissue) was extensively explored in cell therapy for regenera…

Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications

2022

Chondropathies are increasing worldwide, but effective treatments are currently lacking. Mesenchymal stromal cell (MSCs) transplantation represents a promising approach to counteract the degenerative and inflammatory environment characterizing those pathologies, such as osteoarthritis (OA) and rheumatoid arthritis (RA). Umbilical cord- (UC-) MSCs gained increasing interest due to their multilineage differentiation potential, immunomodulatory, and anti-inflammatory properties as well as higher proliferation rates, abundant supply along with no risks for the donor compared to adult MSCs. In addition, UC-MSCs are physiologically adapted to survive in an ischemic and nutrient-poor environment a…

Mesenchymal Stromal cells from Wharton's jelly (MSCs): coupling their hidden differentiative program to their frank immunomodulatory phenotype.

2018

No abstract

The Immunomodulatory Features of Mesenchymal Stromal Cells Derived from Wharton’s Jelly, Amniotic Membrane, and Chorionic Villi In Vitro and In Vivo …

2016

This chapter focuses on the immunomodulatory properties of placental mesenchymal stromal cells (MSCs) derived from the amniotic membrane, umbilical cord, and chorionic villi. Within the amniotic membrane (AM), we discuss the immunomodulatory properties of the two main cell populations that can be isolated from AM: human amniotic mesenchymal stromal cells (hAMSCs) and human amniotic epithelial cells (hAECs). Within the umbilical cord, several compartments have been described, including the amniotic compartment, the Wharton’s jelly (WJ) compartment, and the vascular and perivascular compartment, but herein attention is focused on the properties of human WJ MSCs (hWJMSCs). Since different isol…

MASS-PRODUCED ELEMENT IN STRUCTURAL GLASS: “ARTIFICIAL VINEYARD”

2014

The aim is to design an architectural element flexible and easily adaptable to different urban situations using a material such as glass that, for the last years, is being employed as a structural element. The mass-production is rarely applied to glass construction systems that instead are usually designed case by case. The paper reports the results of a research carried out by the Dipartmento di Architettura and Dipartimento DICAM (Dipartimento di Ingegneria Civile, Ambientale, Aerospaziale, dei Materiali), of the University of Palermo, within the project "VESTRA" (POFESR 2007/2013 - Action Line 4.1.1.1), that aims to the experimentation of mass-produced elements in structural glass. The p…

FLUX CITY HOUSE: re-immaginare il futuro di Manhattan. La centralità del programma nel progetto di New York 2030-2050-2100

2022

In the future, architecture and the city will no longer be a place, but a condition of co-transformative and shared sustainability. In the era of increasing global warming, ecological and energy transition, architecture creates a new balance through the project, at the intertwining of multiple of many fields of knowledge. Sustainability will lead to new perspectives of urban regeneration, as social perspective and a new way of living, consuming and producing, in a broad reverberation of innovations on the ethical and political level of the relationship with societies. Within this frame, the project Flux-city House, winner of the first prize at the “SUAE Asia Winter School Campus: SoHo rezon…

Dynamic Lighting Strategies with Load Modulation Purposes to Reduce Peak Electrical Demand

2018

This paper proposes a study about the feasibility to modulate the indoor artificial lighting, taking into account both achievable energy savings and comfort conditions, in order to reduce lighting electric loads. In particular, it focuses on the possibility, on one hand, to decrease the luminous flux and, on the other hand, to change the Correlated Colour Temperature (CCT), in order to decrease the absorbed power. Moreover, the impact of daylight-linked control systems was considered. Finally, the possibility to combine the different technical solutions was analysed. The paper proposes the definition of daily scheduling referred to lighting energy management, in order to modulate the maximu…