Search results for "Morphism"

Sex Differences in the Physiological Network of Healthy Young Subjects

2021

Within human physiology, systemic interactions couple physiological variables to maintain homeostasis. These interactions change according to health status and are modified by factors such as age and sex. For several physiological processes, sex-based distinctions in normal physiology are present and defined in isolation. However, new methodologies are indispensable to analyze system-wide properties and interactions with the objective of exploring differences between sexes. Here we propose a new method to construct complex inferential networks from a normalization using the clinical criteria for health of physiological variables, and the correlations between anthropometric and blood tests b…

Sexes in gynodioecious Geranium sylvaticum do not differ in their isotopic signature or photosynthetic capacity

2017

In gynodioecious plants, females are expected to produce more or better seeds than hermaphrodites in order to be maintained within the same population. Even though rarely measured, higher seed production can be achieved through differences in physiology. In this work, we measured sexual dimorphism in several physiological traits in the gynodioecious plant Geranium sylvaticum. Photosynthetic rate, stomatal conductance, transpiration rate, WUE and isotopic signatures were measured in plants growing in two habitats differing in light availability. Females have been reported to produce more seeds than hermaphrodites. However, we did not observe any significant difference in seed output between …

Morphological variation of the unionidae mussel Anodonta anatina

2013

ABSTRACT Morphology of a given species can vary among individuals, morphology differences can be found between populations males can be different from females (sexual dimorphism) or e.g. with young and old individuals. The aim of the present study was to investigate morphological variability in the unionidae mussel Anodonta anatina originating from two populations. Measured variables included length, height, width, volume and dry mass of shell, dry mass of soft tissues and gill blades, and age, sex, estimation of glochidium larvae produced. The main results included faster growth of mussels in Lake Koijärvi than in Lake Päijänne (at the age of 4-5 years), which may reflect the higher produc…

Large-scale genotyping identifies 41 new loci associated with breast cancer risk

2013

Journal article Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ~9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC). The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborat…

Trophic ecology of piscivorous Arctic charr (Salvelinus alpinus (L.)) in subarctic lakes with contrasting food-web structures

2019

The trophic ecology of piscivorous Arctic charr (Salvelinus alpinus (L.); charr) in the food webs of large subarctic lakes is not well understood. We assessed charr diets, parasites, growth, maturity, and stable isotope ratios in Fennoscandian subarctic lakes dominated by monomorphic or polymorphic whitefish (Coregonus lavaretus (L.)) populations. Charr density was low in all lakes, except in profundal habitats. Charr shifted to piscivory at small size (16–25 cm total length) and consumed a range of prey-fish sizes (2–25 cm). Cannibalism was observed in a few individuals from one monomorphic whitefish lake. Charr matured at 37–51 cm (5–8 years old), grew to 52–74 cm maximum observed length …

Biomolecular investigation in osteoarthritis

2012

Genomic Tools for the Characterization of Local Animal Genetic Resources: Application in Mascaruna Goat

2022

Italy contains a large number of local goat populations, some of which do not have a recognized genetic structure. The “Mascaruna” is a goat population reared for milk production in Sicily. In this study, a total of 72 individuals were genotyped with the Illumina Goat_IGGC_65K_v2 BeadChip with the aim to characterize the genetic diversity, population structure and relatedness with another 31 Italian goat populations. The results displayed a moderate level of genetic variability for Mascaruna, in concordance with the estimated values for Italian goats. Runs of homozygosity islands are linked to genes involved in milk production, immune response and local adaptation. Population structure anal…

Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry

2009

We conducted meta-analyses of genome-wide association studies (GWAS) for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a novel locus for AF (ZFHX3, rs2106261, risk ratio [RR]=1.19; P=2.3×10−7), an association that was replicated in the German AF Network (odds ratio=1.44; P=1.6×10−11). Combining the discovery and replication results, rs2106261 was significantly associated with AF (RR=1.25; P=1.8×10−15).

Towards Seamless IoT Device-Edge-Cloud Continuum:

2021

In this paper we revisit a taxonomy of client-side IoT software architectures that we presented a few years ago. We note that the emergence of inexpensive AI/ML hardware and new communication technologies are broadening the architectural options for IoT devices even further. These options can have a significant impact on the overall end-to-end architecture and topology of IoT systems, e.g., in determining how much computation can be performed on the edge of the network. We study the implications of the IoT device architecture choices in light of the new observations, as well as make some new predictions about future directions. Additionally, we make a case for isomorphic IoT systems in whic…

TP53 mutations and S-phase fraction but not DNA-ploidy are independent prognostic indicators in laryngeal squamous cell carcinoma

2005

To prospectively evaluate the prognostic significance of TP53, H-, K-, and N-Ras mutations, DNA-ploidy and S-phase fraction (SPF) in patients affected by locally advanced laryngeal squamous cell carcinoma (LSCC). Eight-one patients (median follow-up was 71 months) who underwent resective surgery for primary operable locally advanced LSCC were analyzed. Tumor DNA was screened for mutational analysis by PCR/SSCP and sequencing. DNA-ploidy and SPF were performed by flow cytometric analyses. Thirty-six patients (44%) had, at least, a mutation in the TP53 gene. Of them, 22% (8/36) had double mutations and 3% (1/36) had triple mutations. In total, 46 TP53 mutations were observed. The majority (41…