Search results for "Motif"
showing 10 items of 290 documents
YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS-STING
2022
Ageing is intimately connected to the induction of cell senescence(1,2), but why this is so remains poorly understood. A key challenge isthe identification of pathways that normally suppress senescence, are lost during ageing and are functionally relevant to oppose ageing(3). Here we connected the structural and functional decline of ageing tissues to attenuated function of the master effectors of cellular mechanosignalling YAP and TAZ. YAP/TAZ activity declines during physiological ageing in stromal cells, and mimicking such decline through genetic inactivation of YAP/TAZ in these cells leads to accelerated ageing. Conversely, sustaining YAP function rejuvenates old cells and opposes the e…
Assessment of determinants affecting the dual topology of hepadnaviral large envelope proteins
2004
For functional diversity, the large (L) envelope protein of hepatitis B virus (HBV) acquires a dual transmembrane topology via co-translational membrane integration of the S region and partial post-translational translocation of the preS subdomain. Because each process requires the second transmembrane segment (TM2), we explored the action of this determinant by using protease protection analysis of mutant L proteins. We demonstrated that neither the disruption of a leucine zipper-like motif by multiple alanine substitutions nor the flanking charges of TM2 affected the topological reorientation of L. The dispensability of both putative subunit interaction modules argues against a link betwe…
El frau de l’alquimista en l’infern dantesc de Joan Pasqual i en la tradició medieval
2015
This article presents and analyses chapter XLVI from the Tractat de les penes particulars d’infern by Catalan franciscan friar Joan Pasqual, written soon after 1436. This chapter, “Del cercle de l’alquimia”, includes an exemplum which is doubly significant: on the one hand, it documents the alchemic legend in the Plantagenets’ court during the 14th and 15th centuries; on the other hand, and most importantly, it is a new testimony of two narrative motifs of Eastern origin: the fake alchemist and the king (Thompson, K.111.4; Tubach, 89), and the account-book of mistakes or fools (Thompson,J.1371). After introducing the medieval witnesses of these motifs, the alchemic legend of Ramon Llull and…
Dissection of the relative contribution of the Schizosaccharomyces pombe Ctr4 and Ctr5 proteins to the copper transport and cell surface delivery fun…
2011
The Ctr1 family of proteins mediates high-affinity copper (Cu) acquisition in eukaryotic organisms. In the fission yeastSchizosaccharomyces pombe, Cu uptake is carried out by a heteromeric complex formed by the Ctr4 and Ctr5 proteins. Unlike human andSaccharomyces cerevisiaeCtr1 proteins, Ctr4 and Ctr5 are unable to function independently in Cu acquisition. Instead, both proteins physically interact with each other to form a Ctr4–Ctr5 heteromeric complex, and are interdependent for secretion to the plasma membrane and Cu transport activity. In this study, we usedS. cerevisiaemutants that are defective in high-affinity Cu uptake to dissect the relative contribution of Ctr4 and Ctr5 to the Cu…
Ag+ Complexes as Potential Therapeutic Agents in Medicine and Pharmacy
2019
Silver is a non-essential element with promising antimicrobial and anticancer properties. This work is a detailed summary of the newest findings on the bioinorganic chemistry of silver, with a special focus on the applications of Ag+ complexes and nanoparticles. The coordination chemistry of silver is given a reasonable amount of attention, summarizing the most common silver binding sites and giving examples of such binding motifs in biologically important proteins. Possible applications of this metal and its complexes in medicine, particularly as antibacterial and antifungal agents and in cancer therapy, are discussed in detail. The most recent data on silver nanoparticles are also summari…
Related haloarchaeal pleomorphic viruses contain different genome types
2012
Archaeal viruses have been the subject of recent interest due to the diversity discovered in their virion architectures. Recently, a new group of haloarchaeal pleomorphic viruses has been discovered. It is distinctive in terms of the virion morphology and different genome types (ssDNA/dsDNA) harboured by rather closely related representatives. To date there are seven isolated viruses belonging to this group. Most of these share a cluster of five conserved genes, two of which encode major structural proteins. Putative proviruses and proviral remnants containing homologues of the conserved gene cluster were also identified suggesting a long-standing relationship of these viruses with their ho…
Beyond the myth: A social interpretation about the mosaic of the Twelve Labours of Hercules (Liria, Valencia)
2018
On the occasion of the centenary of the mosaic’s discovery of the Twelve Labours of Hercules in Liria (Valencia), this article aims to approach to some aspects overlooked in previous works. Within the study of Roman domestic spaces, the room’s decoration is an essential factor in order to understand its function. Over the years, several studies have focused their efforts on a descriptive analysis of the mosaic, mentioning only the social interpretation, whereas the current trends try to analyze other aspects such as the study of elites and their symbolism. For this reason, our goal in this article is to analyze the social aspect of this pavement, which particular choice of the central motif…
The Lupa Romana in the Roman provinces
2014
The she-wolf with the twins, Romulus and Remus, was identified as a symbol of Rome by both the Romans themselves and nations under the Roman rule. In this essay I will discuss the Lupa Romana in Roman provincial art. I will present various visual representations of the she-wolf both in the public use and in objects related to private life, and analyze the she-wolf’s symbolic meaning.The Lupa Romana was an iconic scene that was not used randomly in provincial art. It represented in the first place the idea of romanitas, being Roman. In some cases the use of the symbol could have been in consequence of instructions from Rome itself or from provincial authorities that depended on Rome, but in …
Sphères privée et professionnelle chez les enseignants du premier degré : comment priorisent-ils ?
2019
Private and professional lives among primary teachers: how they prioritize? Being a teacher in primary school seems far from allowing the articulation of work and private life in such a comfortable manner as seen in collective beliefs. In order to deconstruct the belief considering teachers as privileged, this contribution proposes, based on empirical results (an online survey with 21,642 responses), to report, first, how primary teachers prioritize their private or professional lives. Second, this paper highlights the reasons which lead them to favour one of the two fields, notably when priority is given to private life at the expense of professional life. Referring to the issue of work-fa…
Discovering representative models in large time series databases
2004
The discovery of frequently occurring patterns in a time series could be important in several application contexts. As an example, the analysis of frequent patterns in biomedical observations could allow to perform diagnosis and/or prognosis. Moreover, the efficient discovery of frequent patterns may play an important role in several data mining tasks such as association rule discovery, clustering and classification. However, in order to identify interesting repetitions, it is necessary to allow errors in the matching patterns; in this context, it is difficult to select one pattern particularly suited to represent the set of similar ones, whereas modelling this set with a single model could…