Search results for "Move"
showing 10 items of 2153 documents
Neuronal receptors display cytoskeleton-independent directed motion on the plasma membrane
2018
Summary Directed transport of transmembrane proteins is generally believed to occur via intracellular transport vesicles. However, using single-particle tracking in rat hippocampal neurons with a pH-sensitive quantum dot probe that specifically reports surface movement of receptors, we have identified a subpopulation of neuronal EphB2 receptors that exhibit directed motion between synapses within the plasma membrane itself. This receptor movement occurs independently of the cytoskeleton but is dependent on cholesterol and is regulated by neuronal activity.
L-selectin regulates human neutrophil transendothelial migration
2021
ABSTRACT The migration of circulating neutrophils towards damaged or infected tissue is absolutely critical to the inflammatory response. L-selectin is a cell adhesion molecule abundantly expressed on circulating neutrophils. For over two decades, neutrophil L-selectin has been assigned the exclusive role of supporting tethering and rolling – the initial stages of the multi-step adhesion cascade. Here, we provide direct evidence for L-selectin contributing to neutrophil transendothelial migration (TEM). We show that L-selectin co-clusters with PECAM-1 – a well-characterised cell adhesion molecule involved in regulating neutrophil TEM. This co-clustering behaviour occurs specifically during …
Sorafenib, but not sunitinib, affects function of dendritic cells and induction of primary immune responses
2008
AbstractThe tyrosine kinase inhibitors sorafenib and sunitinib are approved for the treatment of patients with malignant diseases. To analyze the possible use of these compounds in combination with immunotherapeutic approaches, we analyzed the effects of both inhibitors on the immunostimulatory capacity of human dendritic cells (DCs) and the induction of primary immune responses in vivo. Sorafenib, but not sunitinib, inhibits function of DCs, characterized by reduced secretion of cytokines and expression of CD1a, major histocompatibility complex, and costimulatory molecules in response to TLR ligands as well as by their impaired ability to migrate and stimulate T-cell responses. These inhib…
Chapter 8 Nicotinic receptors of the vertebrate CNS: introductory remarks
1996
Publisher Summary This chapter focuses on the nicotinic receptors of the vertebrate central nervous system (CNS). In vertebrates, nicotinic cholinergic neurotransmission is found in both the CNS and the periphery (muscle endplate). Although muscle and neuronal nicotinic acetylcholine receptors (nAChR) have evolved from a common ancestor, it is striking that the muscle receptor has remained rather stable in evolution, whereas the neuronal receptor has evolved to a wide diversity of subtypes. As an attractive hypothesis, neurotransmitters and neurohormones may not only interact with their archetypic cognate receptors but also with other neuroreceptor, albeit in a modulatory fashion. By modula…
Medium-chain triglycerides may improve memory in non-demented older adults: a systematic review of randomized controlled trials
2022
Abstract Background Ketosis has been exploited for its neuroprotective impact and treatment of neurological conditions via ketone production. Exogenous medium-chain triglyceride (MCT) supplementation may induce nutritional ketosis. The aim of this systematic review is to explore the effects of MCTs on memory function in older adults without cognitive impairment. Methods A systematic literature search of PubMed, Cochrane Library, Scopus, and Web of Science was employed from inception until April 2022 for randomized controlled trials (RCTs) in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, investigating the impact of MCT oils on com…
Population genetics of cucumber mosaic virus infecting medicinal, aromatic and ornamental plants from northern Italy
2012
An epidemiological survey carried at the Herb Garden of Casola Valsenio (Emilia Romagna region; Northern Italy) from 2006 to 2009 resulted in finding Cucumber mosaic virus (CMV) as the infectious agent of several ornamental, medicinal and aromatic plants. All CMV-infected plant species showed leaf symptoms followed, in some cases, by flower colour-breaking and stunting. Genetic analysis consisted in the characterization of movement protein gene of each CMV-isolate by single strand polymorphism analysis and sequencing. Phylogenetic trees identified only two isolates as member of subgroup II, while all other isolates were part of subgroup IA. This survey confirms an unexpected increment of CM…
Genetic variability and evolutionary analysis of parietaria mottle virus: role of selection and genetic exchange
2015
[EN] The genetic variability and evolution of parietaria mottle virus (PMoV) of the genus Ilarvirus was studied by analyzing nucleotide sequences of 2b and CP genes from isolates collected in different countries. Phylogenetic analysis showed that PMoV isolates clustered in different clades: one (clade I) composed of only Italian isolates and three clades (clades II-IV) including the Spanish isolates. The Greek isolate GrT-1 used in this study was in clade IV for the CP phylogenetic tree whereas it formed a separate branch in the 2b phylogenetic tree. The nucleotide sequence diversity of both the 2b and CP genes was low (0.062 +/- A 0.006 and 0.063 +/- A 0.006 for 2b and CP, respectively) bu…
Proscribing the Nordic Resistance Movement in Finland: Analyzing the Process and its Outcome
2021
The Nordic Resistance Movement (NRM) was banned in Finland in 2020 after a court process lasting more than two and half years. This article details how effective the ban has been and how the organization has adapted to the ban, both during the process and after the verdict. The NRM has followed strategies similar to previous proscription cases, especially National Action in the UK in 2016, with whom NRM members discussed and shared experiences before the banning process began. Adaptation has meant new organizational forms and the founding of new associations. Before the ban, some commentators argued that it would only radicalize NRM members and that they might move to clandestine actions. B…
640-Slice CT Measurement of Superior Orbital Fissure as Gateway for Light into the Brain: Statistical Evaluation of Area and Distance.
2016
Objective Our aim was to provide normative data concerning superior orbital fissure area (SOFA), ocular skin and the substantia nigra (D-SS) and orbital fissure and the substantia nigra (D-SOF-S) distances by CT scan in adult Caucasian population. Methods The area of the superior orbital fissure (SOF), the distance between the ocular skin and the substantia nigra and the distance between the superior orbital fissure and the substantia nigra using CT and 3D-CT images. Results Normative data stratified for age and gender were obtained. The data here reported show that some degree of variability in SOFA, D-SS and D-SOF-S measurements can be observed healthy Caucasian subjects. Gender stratifie…
The Argo YBJ daq system and the GRID based data transfer
2008
The Argo-YBJ experiment has now reached itsfinal design configuration. The detector system consists of a fullcoverage array (about 5800 square meters) of Resistive PlateChambers (RPCs). The throughput depends on the trigger rateand threshold. The DAQ system must be able to sustain a max-imum transfer rate of the order of 15 MB/s and a high peakdata flow. Data are read out using a typical front-end acquisitionchain built around a custom bus. Specialized electronics have beendesigned and dedicated software has been written to perform thistask. Data are sent to the online farm through a switch exploitinga gigabit ethernet protocol. A solution to transfer data from theYBJ laboratory to the labo…