Search results for "Multifunction"
showing 10 items of 100 documents
Senataxin defective in ataxia oculomotor apraxia type 2 is involved in the defence against oxidative DNA damage
2007
Adefective response to DNA damage is observed in several human autosomal recessive ataxias with oculomotor apraxia, including ataxia-telangiectasia. We report that senataxin, defective in ataxia oculomotor apraxia (AOA) type 2, is a nuclear protein involved in the DNA damage response. AOA2 cells are sensitive to H2O2, camptothecin, and mitomycin C, but not to ionizing radiation, and sensitivity was rescued with full-length SETX cDNA. AOA2 cells exhibited constitutive oxidative DNA damage and enhanced chromosomal instability in response to H2O2. Rejoining of H2O2-induced DNA double-strand breaks (DSBs) was significantly reduced in AOA2 cells compared to controls, and there was no evidence fo…
Optimized Protocol for the Detection of Multifunctional Epitope-Specific CD4+ T Cells Combining MHC-II Tetramer and Intracellular Cytokine Staining T…
2019
Analysis of multifunctional CD4+ T cells is fundamental for characterizing the immune responses to vaccination or infection. Major histocompatibility complex (MHC)/peptide tetramers represent a powerful technology for the detection of antigen-specific T cells by specific binding to their T-cell receptor, and their combination with functional assays is fundamental for characterizing the antigen-specific immune response. Here we optimized a protocol for the detection of multiple intracellular cytokines within epitope-specific CD4+ T cells identified by the MHC class II tetramer technology. The optimal procedure for assessing the functional activity of tetramer-binding CD4+ T cells was based o…
Relaxation for a Class of Control Systems with Unilateral Constraints
2019
We consider a nonlinear control system involving a maximal monotone map and with a priori feedback. We assume that the control constraint multifunction $U(t,x)$ is nonconvex valued and only lsc in the $x \in \mathbb{R}^{N}$ variable. Using the Q-regularization (in the sense of Cesari) of $U(t,\cdot )$, we introduce a relaxed system. We show that this relaxation process is admissible.
Convergence for varying measures
2023
Some limit theorems of the type $\int_{\Omega}f_n dm_n -- --> \int_{\Omega}f dm$ are presented for scalar, (vector), (multi)-valued sequences of m_n-integrable functions f_n. The convergences obtained, in the vector and multivalued settings, are in the weak or in the strong sense.
The importance of terracing in the traditional cultural landscapes: the case study of Sicily (Italy)
2012
The landscapes formed by agricultural terraces are the natural result of the encounter between the characteristics of an environment and the creative force and genius of man, the slow evolution of this relationship between nature and culture, a collective project that balanced the need for producing with the resources available and the native character of the environment. These cultural processes produced a great variety of landscapes. However, they are not supported or confirmed by common inventories allowing to identify and classify the typical Main Traditional Landscape (MTL) within which very important is the role carried out by terraces and related man-made structures, both for natural…
Bilayer biodegradable films prepared by co-extrusion film blowing: Mechanical performance, release kinetics of an antimicrobial agent and hydrolytic …
2020
Abstract Bilayer biodegradable, eco-friendly films were prepared by co-extrusion film blowing, coupling polylactic acid (PLA) and Bio-flex ® (BIO). Furthermore, in the PLA layer, carvacrol (CRV) was added as a natural antimicrobial additive, whereas a nanoclay (D72T) was integrated to protect CRV from volatilization and to modulate release. The materials were analyzed by morphological, chemical-physical, mechanical testing. Furthermore, CRV release and degradation tests were performed. The results pointed out that coupling the two matrices allows gathering the stiffness of PLA with the ductility of BIO. Furthermore, the interlayer adhesion is promoted by CRV. D72T exerts a key-role in avoid…
Multi-integrals of finite variation
2020
The aim of this paper is to investigate different types of multi-integrals of finite variation and to obtain decomposition results.
Description of the limit set of Henstock–Kurzweil integral sums of vector-valued functions
2015
Abstract Let f be a function defined on [ 0 , 1 ] and taking values in a Banach space X . We show that the limit set I HK ( f ) of Henstock–Kurzweil integral sums is non-empty and convex when the function f has an integrable majorant and X is separable. In the same setting we give a complete description of the limit set.
A decomposition theorem for compact-valued Henstock integral
2006
We prove that if X is a separable Banach space, then a measurable multifunction Γ : [0, 1] → ck(X) is Henstock integrable if and only if Γ can be represented as Γ = G + f, where G : [0, 1] → ck(X) is McShane integrable and f is a Henstock integrable selection of Γ.
On the points realizing the distance to a definable set
2011
Abstract We prove a definable/subanalytic version of a useful lemma, presumably due to John Nash, concerning the points realizing the Euclidean distance to an analytic submanifold of R n . We present a parameter version of the main result and we discuss the properties of the multifunction obtained.