Search results for "Multiple"

Cytotoxicity of three naturally occurring flavonoid derived compounds (artocarpesin, cycloartocarpesin and isobavachalcone) towards multi-factorial d…

2015

Abstract Introduction Cancer remains an aggressive deadly disease, if drug resistance develops. This problem is aggravated by the fact that multiple rather than single mechanisms are involved in resistance and that multidrug resistance (MDR) phenomena cause inefficacy of many clinical established anticancer drugs. We are seeking for novel cytotoxic phytochemicals to combat drug-resistant tumour cells. Methods In the present study, we investigated the cytotoxicity of three naturally occurring flavonoids including two flavones artocarpesin (1) and cycloartocarpesin (2) and one chalcone, isobavachalcone (3) against 9 drug-sensitive and MDR cancer cell lines. The resazurin reduction assay was u…

Channel aggregation with guard-band in D-OFDM based CRNs: Modeling and performance evaluation

2016

Channel aggregation (CA) techniques can offer flexible channel allocation and improve overall system performance in multi-channel cognitive radio networks (CRNs). Although many CA techniques have been proposed and studied, the impact of guard-band on CA for channel access has not been addressed in-depth. In this paper, we study the guard-band allocation mechanisms in discontinuous-orthogonal frequency division multiplexing (D-OFDM) based CRNs, and investigate the impact of guard-band sharing on SU flows when CA is enabled. Continuous time Markov chain (CTMC) based models have been developed in order to investigate the stochastic behavior of PU and SU flows. Based on our mathematical analysi…

Analog joint source-channel Multiple Description coding scheme over AWGN parallel channels

2011

We propose a low complexity analog joint source channel coding Multiple Description (MD) scheme for transmitting the symbols of a Gaussian source across a pair of independent AWGN channels. The outputs of these channels have each a separated receiver, whereas a third receiver has both outputs available. At the transmitter side, a pair of bandwidth-reduction analog mappings are used for joint source-channel coding. The presented scheme has the inherent advantage over digital MD schemes based on separation, that coding and decoding can be performed by using a single-letter (or symbol), a strategy that is very suitable for applications where latency originated by the digital compression and th…

13C NMR study on the methoxy carbon chemical shifts in chloro-substituted anisoles and guaiacols

1983

The 13C NMR chemical shifts of methoxy carbons in chlorinated anisoles and guaiacols have been measured for acetone-d6 solutions. Multiple linear regression analysis, and also ‘simple sum rule’ calculations, have been used to estimate the effects of the chlorine atoms (the position and degree of substitution) on the chemical shifts. The most important effects have shown to be due to the chlorine atoms adjacent to the methoxy and hydroxy substituents. For chlorinated guaiacols, the greatest effect is due to the chlorine atom adjacent to the methoxy group. For chlorinated anisoles, the substituents adjacent to the methoxy group (2,6-disubstitution) cause large effects. For both groups of comp…

Biomolecule-corona formation confers resistance of bacteria to nanoparticle-induced killing: Implications for the design of improved nanoantibiotics

2018

Abstract Multidrug-resistant bacterial infections are a global health threat. Nanoparticles are thus investigated as novel antibacterial agents for clinical practice, including wound dressings and implants. We report that nanoparticles' bactericidal activity strongly depends on their physical binding to pathogens, including multidrug-resistant primary clinical isolates, such as Staphylococcus aureus , Klebsiella pneumoniae or Enterococcus faecalis . Using controllable nanoparticle models, we found that nanoparticle-pathogen complex formation was enhanced by small nanoparticle size rather than material or charge, and was prevented by 'stealth' modifications. Nanoparticles seem to preferentia…

Solution Processed Micro- and Nano-Bioarrays for Multiplexed Biosensing

2012

This Feature article reports on solution dispensing methodologies which enable the realization of multiplexed arrays at the micro- and nanoscale for relevant biosensing applications such as drug screening or cellular chips.

Drimane-type Sesquiterpene Coumarins from Ferula gummosa Fruits Enhance Doxorubicin Uptake in Doxorubicin-resistant Human Breast Cancer Cell Line

2014

ABSTRACT Multidrug resistance (MDR) is the main cause of failure in the chemotherapy of cancer patients. The present study aimed to evaluate the effects of sesquiterpene coumarins of Ferula gummosa fruits on P-glycoprotein (P-gp)–mediated MDR. Drimane-type sesquiterpene coumarins from the fruits of F. gummosa were extracted with dichloromethane and subjected to column chromatography. The effects of the isolated compounds on P-gp–mediated MDR were evaluated in the breast cancer cell line MCF-7 which shows high resistance to doxoribicin (MCF-7/Dox). Phytochemical investigation of dichloromethane extract of F. gummosa fruits resulted in three sesquiterpene coumarins including conferone (1), mo…

The action of TH17 cells on blood brain barrier in multiple sclerosis and experimental autoimmune encephalomyelitis.

2019

Th17 cells, known as a highly pro-inflammatory subtype of Th cells, are involved very early in numerous aspects of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) neuropathology. A crucial event for the formation and accumulation of MS lesions is represented by the disruption of the blood brain barrier (BBB) in relapsing-remitting MS. Th17 cells also contribute to the progression of MS/EAE. These events will allow for the passage of inflammatory cells into the brain. Secondary to this, increased recruitment of neutrophils occurs, followed by increased protease activity that will continue to attract macrophages and monocytes, leading to brain inflammation with sus…

From Molecular Tumor Diagnostics to Individualized Treatment with Phytochemicals Derived from Chinese Herbs

2011

Collateral Sensitivity in Drug-Resistant Tumor Cells

2013

Collateral sensitivity is a term for the hypersensitivity of otherwise drug-resistant cells. The selective killing of tumor cells by drugs exerting collateral sensitivity might be used as a novel treatment strategy. In this chapter, we give an overview on drug resistance phenotypes with known collateral sensitivities; furthermore, their molecular and cellular mechanisms were discussed to explain mediation of these hypersensitivities.