Search results for "NPL"
showing 10 items of 45 documents
Characteristics of patients with an unplanned admission to an acute palliative care unit
2016
The aim of this cohort study is to compare the symptom burden of patients who have an unplanned admission to an acute palliative care unit (APCU) with patients who have a regular planned admission. A consecutive sample of advanced cancer patients who were admitted to an APCU was prospectively assessed. The reasons and the kind of admission were recorded (unplanned, UP, or planned, P). Anticancer treatments, whether patients were on/off treatment or uncertain, previous care setting, and who referred the patient to the unit were also recorded. The Edmonton Symptom Assessment Scale (ESAS) was used at admission and at time of discharge, as well as the Memorial Delirium Assessment Scale. Analges…
Phonon-induced spin relaxation of conduction electrons in silicon crystals
2014
Experimental works managing electrical injection of spin polarization in n-type and p-type silicon have been recently carried out up to room-temperature. In spite of these promising experimental results, a comprehensive theoretical framework concerning the influence of transport conditions on phonon-induced electron spin depolarization in silicon structures, in a wide range of values of lattice temperature, doping concentration and amplitude of external fields, is still at a developing stage. In order to investigate the spin transport of conduction electrons in lightly doped n-type Si crystals, a set of semiclassical multiparticle Monte Carlo simulations has been carried out. The mean spin …
Glial expression of Swiss cheese (SWS), the Drosophila orthologue of neuropathy target esterase (NTE), is required for neuronal ensheathment and func…
2016
ABSTRACT Mutations in Drosophila Swiss cheese (SWS) or its vertebrate orthologue neuropathy target esterase (NTE), respectively, cause progressive neuronal degeneration in Drosophila and mice and a complex syndrome in humans that includes mental retardation, spastic paraplegia and blindness. SWS and NTE are widely expressed in neurons but can also be found in glia; however, their function in glia has, until now, remained unknown. We have used a knockdown approach to specifically address SWS function in glia and to probe for resulting neuronal dysfunctions. This revealed that loss of SWS in pseudocartridge glia causes the formation of multi-layered glial whorls in the lamina cortex, the firs…
Identification of molecular pathophysiological mechanisms of non-alcoholic fatty liver disease (NAFLD)
2018
Alkohola neizraisītā taukaino aknu slimība (NATAS) ietver plaša spektra izmaiņas aknās: no pārmērīgas tauku uzkrāšanās līdz pat cirozei. NATAS ģenētiskās komponentes noteikšanai tika veikta visa genoma asociāciju pētījumus (GWAS). Polimorfismi Pnpla3 (I148M; rs738409) un Tm6sf2 (E167K; rs58542926) gēnos ir asociēti ar paaugstinātu lipīdu uzkrāšanos aknās. PNPLA3 I148M varianta proteīns pastiprināti uzkrājas uz šūnu tauku lodīšu virsmas, kas traucē tauku lodīšu normālu funkciju. Proteīna TM6SF2 167K variants izraisa proteīna nestabilitāti un ātrāku tā degradāciju. Tālākie pētījumi parāda, ka TM6SF2 ir saistīts ar aknu ļoti zema blīvuma lipoproteīnu (VLDL) veidošanu vai ekskrēciju. Izpratne p…
El ciclo económico y la morosidad
2016
Basado en las variables utilizadas por el informe de Oliver Wyman, modificando y eliminado las redundantes, se elabora un modelo econométrico para estimar la morosidad de las entidades de crédito españolas. Las variables son el PIB, el deflactor, el desempleo, la bolsa, los créditos, el Euribor, el precio de las viviendas el tipo de cambio y na variable ficticia para que representa el SAREB. Además se contrasta si el modelo es óptimo para para largos periodos de tiempo. Los resultados obtenidos evidencian que el modelo construido con datos provenientes de épocas de recesión no es válido para épocas de crecimiento.
Comparison of the circulation of non-steroidal anti-inflammatory drugs in pharmacy in 2018 and 2021
2022
Nesteroīdie pretiekaisuma līdzekļi ir vieni no patērētākajiem medikamentiem pasaulē, taču to lietošanā pastāv riski, kas saistīti ar nelabvēlīgām blakusparādībām, zāļu mijiedarbībām un kontrindikācijām. Bieži vien šie riski rodas sabiedrības neinformētības dēļ saistībā ar nesteroīdo pretiekaisuma līdzekļu lietošanu. Darba mērķis: Noskaidrot, vai pēdējo gadu laikā ir palielinājies nesteroīdo pretiekaisuma līdzekļu patēriņš, ņemot vērā Covid-19 infekcijas izplatības periodu; noskaidrot vai aptiekā strādājošie farmācijas speciālisti informē aptiekas klientus par nesteroīdo pretiekaisuma līdzekļu pareizu lietošanu un riskiem; noskaidrot nesteroīdo pretiekaisuma līdzekļu patērētāju lietošanas pa…
The burden of hepatocellular carcinoma in non-alcoholic fatty liver disease: Screening issue and future perspectives
2019
In recent decades, non-alcoholic fatty liver disease (NAFLD) has become the most common liver disease in the Western world, and the occurrence of its complications, such as hepatocellular carcinoma (HCC), has rapidly increased. Obesity and diabetes are considered not only the main triggers for the development of the disease, but also two independent risk factors for HCC. Single nucleotide polymorphisms (such as PNPLA3, TM6SF2 and MBOAT7) are related to the susceptibility to the development of HCC and its progression. Therefore, an appropriate follow-up of these patients is needed for the early diagnosis and treatment of HCC. To date, international guidelines recommend the use of ultrasonogr…
Field Dependence of the Electron Spin Relaxation in Quantum Dots
2005
Interaction of the electron spin with local elastic twists due to transverse phonons has been studied. Universal dependence of the spin relaxation rate on the strength and direction of the magnetic field has been obtained in terms of the electron gyromagnetic tensor and macroscopic elastic constants of the solid. The theory contains no unknown parameters and it can be easily tested in experiment. At high magnetic field it provides parameter-free lower bound on the electron spin relaxation in quantum dots.
Theory of Kondo suppression of spin polarization in nonlocal spin valves
2016
We theoretically analyze contributions from the Kondo effect to the spin polarization and spin diffusion length in all-metal nonlocal spin valves. Interdiffusion of ferromagnetic atoms into the normal metal layer creates a region in which Kondo physics plays a significant role, giving discrepancies between experiment and existing theory. We start from a simple model and construct a modified spin drift-diffusion equation which clearly demonstrates how the Kondo physics not only suppresses the electrical conductivity but even more strongly reduces the spin diffusion length. We also present an explicit expression for the suppression of spin polarization due to Kondo physics in an illustrative …
Direct observation of spin wave focusing by a Fresnel lens
2020
Spin waves are discussed as promising information carrier for beyond complementary metal-oxide semiconductor data processing. One major challenge is guiding and steering of spin waves in a uniform film. Here, we explore the use of diffractive optics for these tasks by nanoscale real-space imaging using x-ray microscopy and careful analysis with micromagnetic simulations. We discuss the properties of the focused caustic beams that are generated by a Fresnel-type zone plate and demonstrate control and steering of the focal spot. Thus, we present a steerable and intense nanometer-sized spin-wave source. Potentially, this could be used to selectively illuminate magnonic devices like nano-oscill…