Search results for "NVO"
showing 10 items of 2061 documents
A Genome-Wide Association Study of Attention Function in a Population-Based Sample of Children
2016
BACKGROUND: Attention function filters and selects behaviorally relevant information. This capacity is impaired in some psychiatric disorders and has been proposed as an endophenotype for Attention-Deficit/Hyperactivity Disorder; however, its genetic basis remains largely unknown. This study aimed to identify single nucleotide polymorphism (SNPs) associated with attention function. MATERIALS AND METHODS: The discovery sample included 1655 children (7-12 years) and the replication sample included 546 children (5-8 years). Five attention outcomes were assessed using the computerized Attentional Network Test (ANT): alerting, orienting, executive attention, Hit Reaction time (HRT) and the stand…
Role of Vitamin A in Mammary Gland Development and Lactation
2019
Vitamin A (all-trans-retinol), its active derivatives retinal and retinoic acid, and their synthetic analogues constitute the group of retinoids. It is obtained from diet either as preformed vitamin A or as carotenoids. Retinal plays a biological role in vision, but most of the effects of vitamin A are exerted by retinoic acid, which binds to nuclear receptors and regulates gene transcription. Vitamin A deficiency is an important nutritional problem, particularly in the developing world. Retinol and carotenoids from diet during pregnancy and lactation influence their concentration in breast milk, which is important in the long term, not only for the offspring, but also for maternal health. …
Taxonomic Classification for Living Organisms Using Convolutional Neural Networks
2017
Taxonomic classification has a wide-range of applications such as finding out more about evolutionary history. Compared to the estimated number of organisms that nature harbors, humanity does not have a thorough comprehension of to which specific classes they belong. The classification of living organisms can be done in many machine learning techniques. However, in this study, this is performed using convolutional neural networks. Moreover, a DNA encoding technique is incorporated in the algorithm to increase performance and avoid misclassifications. The algorithm proposed outperformed the state of the art algorithms in terms of accuracy and sensitivity, which illustrates a high potential f…
Deconvolution of the cellular origin in hepatocellular carcinoma: Hepatocytes take the center stage.
2016
The expression of biliary/progenitor markers by hepatocellular carcinoma (HCC) is often associated with poor prognosis and stem cell-like behaviors of tumor cells. Hepatocellular adenomas (HCA) also often express biliary/progenitor markers and frequently act as precursor lesions for HCC. However, the cell of origin of HCA and HCC that expresses these markers still remains unclear. Therefore, to evaluate if mature hepatocytes give rise to HCA and HCC tumors, and to understand the molecular pathways involved in tumorigenesis, we lineage-labeled hepatocytes by injecting adeno-associated virus (AAV) containing thyroxine-binding globulin (TBG) promoter driven-Cre into RosaYFP mice. Yellow fluore…
Assessing the Contribution of Relative Macrophage Frequencies to Subcutaneous Adipose Tissue
2021
Background: Macrophages play an important role in regulating adipose tissue function, while their frequencies in adipose tissue vary between individuals. Adipose tissue infiltration by high frequencies of macrophages has been linked to changes in adipokine levels and low-grade inflammation, frequently associated with the progression of obesity. The objective of this project was to assess the contribution of relative macrophage frequencies to the overall subcutaneous adipose tissue gene expression using publicly available datasets.Methods: Seven publicly available microarray gene expression datasets from human subcutaneous adipose tissue biopsies (n = 519) were used together with TissueDecod…
Identifying and understanding spa tourists’ wellness attitudes
2018
As an increasing number of people in affluent societies are trending toward more health-conscious lifestyles, tourism consumer behavior has changed considerably, especially in the spa and wellness ...
Burnout-related ill-being at work : Associations between mindfulness and acceptance skills, worksite factors, and experienced well-being in life
2018
The aim of this paper was to investigate the associations between mindfulness and acceptance (MAA) skills and burnout-related ill-being at work (ILLB) after eliminating the impact of worksite (WS) and general well-being in life (WELLB) factors. The results were derived from data on employees (n = 168) of varying professional backgrounds, who experienced relatively high levels of burnout. Analyses were conducted using structural equation modelling (SEM) and the Cholesky decomposition method, since these allow for the investigation of multiple measures and multiple factors in relation to one another. In relation to ill-being at work, the analyses revealed a general MAA factor as well as a spe…
Charitable food aid in Finland: from a social issue to an environmental solution
2019
Since the establishment of the first food bank in 1995, charitable food aid (CFA) has become entrenched in Finland as a seemingly irreplaceable solution to food poverty. Further, it has recently been suggested that the focus of food aid activities is shifting from food poverty and temporary hunger alleviation towards environmental sustainability through addressing food waste via organized re-distribution of expiring food from retail to charitable organizations. This potentially creates a mechanism that (1) solidifies food poverty and (2) fortifies the paradoxical situation where charitable organizations delivering food aid are dependent on food waste rather than trying to reduce it. To unde…
¿Atenuación del compromiso del hablante?: el caso de los evidenciales "por lo visto" y "se ve que"
2018
espanolBuena parte de la bibliografia sobre marcadores evidenciales en espanol senala la atenuacion del compromiso (o responsabilidad) de lo dicho como uno de sus rasgos definitorios. Sin embargo, tanto la nocion de atenuacion como la de compromiso del hablante se han empleado con distintas acepciones, segun los trabajos. En primer lugar, se revisan estas acepciones y se propone, siguiendo a Cornillie/Delbecque, distinguir las nociones compromiso del hablante de implicacion del hablante, las cuales funcionan de manera inversa en algunos usos evidenciales: (i) de las evidencias reportativas a las inferenciales conjeturales hay una escala de menos a mas implicacion del hablante; (ii) en las e…
Varieties of algebras with pseudoinvolution and polynomial growth
2017
Let A be an associative algebra with pseudoinvolution (Formula presented.) over an algebraically closed field of characteristic zero and let (Formula presented.) be its sequence of (Formula presented.) -codimensions. We shall prove that such a sequence is polynomially bounded if and only if the variety generated by A does not contain five explicitly described algebras with pseudoinvolution. As a consequence, we shall classify the varieties of algebras with pseudoinvolution of almost polynomial growth, i.e. varieties of exponential growth such that any proper subvariety has polynomial growth and, along the way, we shall give also the classification of their subvarieties. Finally, we shall de…