Search results for "Native"

Cytotoxicity and modes of action of three naturally occurring xanthones (8-hydroxycudraxanthone G, morusignin I and cudraxanthone I) against sensitiv…

2014

Abstract Background Resistance of cancer to chemotherapy remains a challenging issue for scientists as well as physicians. Naturally occurring xanthones possess a variety of biological activities such as anti-inflammatory, anti-bacterial, and anti-cancer effects. The present study was aimed at investigating the cytotoxicity and the modes of action of three naturally occurring xanthones namely, morusignin I (1), 8-hydroxycudraxanthone G (2) and cudraxanthone I (3) against a panel of nine cancer cell lines, including various sensitive and drug-resistant phenotypes. Methods The cytotoxicity of the compounds was determined using a resazurin reduction assay, whereas the caspase-Glo assay was use…

Evolución de la desinformación sobre COVID-19 en Argentina a través de los desmentidos del verificador Chequeado

2022

Este trabajo estudia la evolución de la desinformación sobre COVID-19 en Argentina desde la declaración de la situación de pandemia por la OMS en marzo de 2020 hasta junio de 2021. La investigación aplica un análisis de contenido de cuatro variables —intención, temática, protagonismo y apelación emocional— a los 154 desmentidos publicados al respecto en dicho periodo por el medio Chequeado, único del país acreditado por la International Fact-Checking Network. Los resultados evidencian el predominio de la intención desestabilizadora, la temática negacionista, el protagonismo de las instituciones y del personal sanitario, y la apelación emocional negativa. Además, la puesta en relación de dic…

Cytotoxicity of compounds from Xylopia aethiopica towards multi-factorial drug-resistant cancer cells.

2015

Abstract Introduction Multidrug resistance (MDR) in cancer represent a major hurdle in chemotherapy. Previously, the methanol extract of the medicinal spice Xylopia aethiopica displayed considerable cytotoxicity against multidrug resistant (MDR) cancer cell lines. Methods The present study was designed to assess the cytotoxicity of compounds, 16 α -hydroxy- ent -kauran-19-oic acid ( 2 ), 3,4′,5-trihydroxy-6″,6″-dimethylpyrano[2,3-g]flavone ( 3 ), isotetrandrine ( 5 ) and trans -tiliroside ( 6 ) derived from the methanol crude extract of Xylopia aethiopica against 9 drug-sensitive and -resistant cancer cell lines. The resazurin reduction assay was used to evaluate the cytotoxicity of these c…

Alternative splicing regulation by Muscleblind proteins: from development to disease.

2011

Regulated use of exons in pre-mRNAs, a process known as alternative splicing, strongly contributes to proteome diversity. Alternative splicing is finely regulated by factors that bind specific sequences within the precursor mRNAs. Members of the Muscleblind (Mbl) family of splicing factors control critical exon use changes during the development of specific tissues, particularly heart and skeletal muscle. Muscleblind homologs are only found in metazoans from Nematoda to mammals. Splicing targets and recognition mechanisms are also conserved through evolution. In this recognition, Muscleblind CCCH-type zinc finger domains bind to intronic motifs in pre-mRNA targets in which the protein can e…

Enhancement and assessment of WKS variance parameter for intelligent 3D shape recognition and matching based on MPSO

2016

This paper presents an improved wave kernel signature (WKS) using the modified particle swarm optimization (MPSO)-based intelligent recognition and matching on 3D shapes. We select the first feature vector from WKS, which represents the 3D shape over the first energy scale. The choice of this vector is to reinforce robustness against non-rigid 3D shapes. Furthermore, an optimized WKS-based method for extracting key-points from objects is introduced. Due to its discriminative power, the associated optimized WKS values with each point remain extremely stable, which allows for efficient salient features extraction. To assert our method regarding its robustness against topological deformations,…

Glyphosate : comment sortir de l’impasse ? L’expertise d’un chercheur agronome

2018

International audience

The production of an infant formula with a minimally processed route impacts its nutritional, physiological and sensorial qualities

2021

International audience

Bioalternatives to chemicals in plant production and in cleaning up the environment: hopes and reality

2012

INRA - 10 ans d'essais de systèmes de culture en protection intégrée - La Flore adventice est maîtrisable par les techniques alternatives aux herbici…

2012

EA EcolDur CT1 D'après le communiqué du service de presse de l'INRA "10 ans d'expérimentation à l'INRA de Dijon en protection intégrée. Comment réduire l'utilisation d'herbicides en grande culture." (interview de N. Munier-Jolain, film 2 min.); National audience

Species-specific prey choice of carabid beetles in European cereal fields

2017

National audience; Trophic interactions between species in agroecosystems provide key regulation ecosystem services and therefore also determine the dynamics, robustness and resilience of service provision. To achieve international goals of reducing application of pesticides without compromising key provisioning ecosystem services such as crop yield, recent research attaches importance to the biological control potential of carabid beetles. However, apart from feeding on pest species and weed seeds, carabids also consume non-pest prey (alternative prey) such as collembolans and earthworms, which can play a contradictory role in the efficacy of pest and weed control. Most carabids are descri…