Search results for "Native"
showing 10 items of 1727 documents
Secoiridoids and Iridoids from Morinda asteroscepa
2020
The new 2,3-secoiridoids morisecoiridoic acids A (1) and B (2), the new iridoid 8-acetoxyepishanzilactone (3), and four additional known iridoids (4–7) were isolated from the leaf and stem bark methanol extracts of Morinda asteroscepa using chromatographic methods. The structure of shanzilactone (4) was revised. The purified metabolites were identified using NMR spectroscopic and mass spectrometric techniques, with the absolute configuration of 1 having been established by single-crystal X-ray diffraction analysis. The crude leaf extract (10 μg/mL) and compounds 1–3 and 5 (10 μM) showed mild antiplasmodial activities against the chloroquine-sensitive malaria parasite Plasmodium falciparum (…
Artemisinin derivatives induce iron-dependent cell death (ferroptosis) in tumor cells
2015
Abstract Background Apoptosis and other forms of cell death have been intensively investigated in the past years to explain the mode of action of synthetic anticancer drugs and natural products. Recently, a new form of cell death emerged, which was termed ferroptosis, because it depends on intracellular iron. Here, the role of genes involved in iron metabolism and homeostasis for the cytotoxicity of ten artemisinin derivatives have been systematically investigated. Material and methods Log10IC50 values of 10 artemisinin derivatives (artesunate, artemether, arteether, artenimol, artemisitene, arteanuin B, another monomeric artemisinin derivative and three artemisinin dimer molecules) were co…
Response of the oxygen sensor NreB to air in vivo: Fe-S-containing NreB and apo-NreB in aerobically and anaerobically growing Staphylococcus carnosus.
2009
ABSTRACT The sensor kinase NreB from Staphylococcus carnosus contains an O 2 -sensitive [4Fe-4S] 2+ cluster which is converted by O 2 to a [2Fe-2S] 2+ cluster, followed by complete degradation and formation of Fe-S-less apo-NreB. NreB·[2Fe-2S] 2+ and apoNreB are devoid of kinase activity. NreB contains four Cys residues which ligate the Fe-S clusters. The accessibility of the Cys residues to alkylating agents was tested and used to differentiate Fe-S-containing and Fe-S-less NreB. In a two-step labeling procedure, accessible Cys residues in the native protein were first labeled by iodoacetate. In the second step, Cys residues not labeled in the first step were alkylated with the fluorescent…
What is new for an old molecule? : Systematic review and recommendations on the use of resveratrol
2011
BackgroundResveratrol is a natural compound suggested to have beneficial health effects. However, people are consuming resveratrol for this reason without having the adequate scientific evidence for its effects in humans. Therefore, scientific valid recommendations concerning the human intake of resveratrol based on available published scientific data are necessary. Such recommendations were formulated after the Resveratrol 2010 conference, held in September 2010 in Helsingør, Denmark.MethodologyLiterature search in databases as PUBMED and ISI Web of Science in combination with manual search was used to answer the following five questions: (1)Can resveratrol be recommended in the prevention…
Evaluation of innovative thermal insulation systems for a sustainable envelope
2017
La memoria presenta i risultati ottenuti su sistemi di isolamento termico per l’involucro edilizio. Si presentano i risultati ottenuti tramite simulazioni informatiche che hanno consentito di verificare e ottimizzare la trasmissione del calore attraverso un sistema sottovuoto in vetro per le facciate trasparenti. Inoltre la possibilità offerta dal riciclo del materiale di scarto della potatura dell’Opunthia Ficus Indica (fichi d’india) che,opportunamente trattato ha permesso di ottenere un materiale isolante (Brevetto n. 1402131), in forma di pannello o in grani sfusi, (valori di coibenza termica 0.0710.057 W/mK). The paper presents the results of the research on thermal insulation systems…
Japanese attitudes towards their English pronunciation
2014
Vaikka englantia puhutaankin nykyään enimmäkseen vieraana kielenä, on äidinkielenä puhuttu englanti yhä standardi kielen opetuksessa. Monelle englannin oppijalle se on myös ainoa oikea tapa puhua englantia. Tämä on havaittavissa myös Japanissa, jossa englannin kielen äidinkielenkaltainen osaaminen on vaikeata saavuttaa, ja japanilaisten asenteet omaa englannin ääntämystään kohtaan ovat hyvin negatiivisia. Tutkimuksen tarkoituksena oli jatkaa aiempien tutkimusten työtä uudenlaisella otannalla, ja mitata japanilaisten asenteita omaa englannin kielen ääntämistään kohtaan sekä tarkastella näihin asenteisiin vaikuttavia muuttujia. Tutkimus suoritettiin kyselyllä, jossa mitattiin vastaajien asent…
P2PRealm - Peer-to-Peer Network Simulator
2006
Peer-to-peer realm (P2PRealm) is an efficient peer-to-peer network simulator for studying algorithms based on neural networks. In contrast to many simulators, which emphasize on detailed network simulation, the speed of simulation in P2PRealm is essential, because neural networks require a time consuming training phase. Efficiency has been obtained by optimizing training loops inside the simulator, using Java native interface (JNI) as well as distributing the simulator to hundreds of workstations using the P2PDisCo platform. In this paper we describe the architecture of P2PRealm and its input/output interfaces. Also, we present the mechanisms used for internally optimizing the implementatio…
React Native ietvarā izstrādātu Android un iOS lietotņu salīdzinājums
2018
React Native ietvars nodrošina iOS un Android lietotņu izstrādi, izmantojot JavaScript programmēšanas valodu un React. Bakalaura darba mērķis ir izpētīt React Native ietvara darbības principus un sniegtās iespējas, analizējot un veicot React Native ietvarā veidotu iOS un Android lietotņu izstrādes procesu salīdzinājumu, lai noskaidrotu, vai kādai no platformām ir nepieciešams veikt vairāk funkcionālo pielāgojumu, lai nodrošinātu to pašu lietotnes funkcionalitāti. Darba rezultātā ir izveidota iOS un Android lietotne, kā arī ir veikta lietotnes izstrādes procesu analīze un salīdzinājums. Salīdzinājuma rezultātā tika noskaidrots, ka React Native ietvars nodrošina līdzvērtīgu iOS un Android lie…
Las ADR en la justicia del siglo XXI, en especial la mediación (The Alternative Dispute Resolution ‘ADR’ in the Justice of the 21st Century, Especial…
2011
Spanish Abstract: El presente ensayo busca exponer en torno a experiencias poco analizadas por los sistemas juridicos europeos de corte continental, pero muy bien conocidas por los sistemas anglosajones. El objetivo trazado es fomentar el debate en torno a estas alternativas para la resolucion de los conflictos en la sociedad, con especial atencion a la mediacion. English Abstract: This is essay seeks to expose not very much analyzed experiences by the legal systems of the continental Europeans, but very well known by the Anglo-Saxon systems. The stated goal is to encourage debate on these alternatives to resolve conflicts in society, with special attention to mediation.
Kalanchoe pinnata inhibits mast cell activation and prevents allergic airway disease
2011
Aqueous extract of Kalanchoe pinnata (Kp) have been found effective in models to reduce acute anaphylactic reactions. In the present study, we investigate the effect of Kp and the flavonoid quercetin (QE) and quercitrin (QI) on mast cell activation in vitro and in a model of allergic airway disease in vivo. Treatment with Kp and QE in vitro inhibited degranulation and cytokine production of bone marrow-derived mast cells following IgE/FcɛRI crosslinking, whereas treatment with QI had no effect. Similarly, in vivo treatment with Kp and QE decreased development of airway hyperresponsiveness, airway inflammation, goblet cell metaplasia and production of IL-5, IL-13 and TNF. In contrast, treatm…