Search results for "Need to know"
showing 10 items of 20 documents
Startup Metrics That Tech Entrepreneurs Need to Know
2020
Metrics can be used by firms to make more objective decisions based on data. Software startups in particular are characterized by the uncertain or even chaotic nature of the contexts in which they operate. Using data in the form of metrics can help software startups to make the right decisions amid uncertainty and limited resources. However, whereas conventional business metrics and software metrics have been studied in the past, metrics in the specific context of software startups have not been studied. In this chapter, we present the results of a multivocal literature review to offer you 118 metrics practitioner experts think software startups should measure. These metrics can give you id…
Exploiting a list of protein sequences
2007
Abstract: We describe a software program to help exploit a database of aligned protein sequences. In addition to the classical lists of sequences, a graphical representation is used to get a better overview of the information. As natural parameters, the type of amino acid and sequence position are used. Various plots or 3D representations are then updated. Examples are shown based on globin sequences from various species and on the abnormal human hemoglobins. The software should be of interest to protein engineers who need to know what variants are already known.
2021
Abstract Terrestrial Essential Climate Variables, known as terrestrial ECVs, are key sources of information for both application- and scientific- oriented research. A large number of global terrestrial ECV products have been derived from satellite observations, and more are forthcoming. To unlock the full potential of these products, end-users need to know their uncertainties and error magnitudes. Due to the lack of conformity among validation strategies, a wide range of validation approaches have been employed to assess the quality of these products, and have resulted in reduced comparability even for the same terrestrial ECV. Addressing this challenge in validation practices requires the …
Reliability Generalization Meta-Analysis
2020
Un meta-análisis de generalización de confiabilidad (MA GF) es un método para integrar estadísticamente las estimaciones de fiabilidad obtenidas en diferentes aplicaciones de un test. El MA GF permite a los investigadores caracterizar la fiabilidad promedio de las puntuaciones obtenida en un test en múltiples estudios y situaciones y estimar el grado de variabilidad en los coeficientes de fiabilidad en diferentes tipos de medidas, muestras y contextos. Por lo tanto, sus resultados permiten ofrecer pautas a los investigadores y profesionales aplicados sobre qué escalas son más fiables para evaluar un constructo y en qué circunstancias. Así pues, los investigadores y profesionales necesitan s…
Social research on human resources. The need to follow a methodology
2008
The aim of this article is to highlight the current need to know the reality around them by professionals that manage people in organisations. It is through a systematic process of social research what they will allow to take decisions more timely and adequate to achieve the objectives of the organization, understanding them in a broader sense which would also include issues such as security, quality of life and development of workers, among others.
The new world of biosimilars: what diabetologists need to know about biosimilar insulins
2010
Biosimilar pharmaceuticals are emerging as patent protection on the original biopharmaceutical products expires. However, biopharmaceuticals are particularly complex molecules, and biosimilar insulins present special challenges. In part this reflects their structure and chemical modification after synthesis to attain a biologically active form. Their therapeutic window is narrow and the accuracy of their dosing is highly dependent on the formulation and quality of the administration device. For these reasons, the European Medicines Agency has issued stringent guidelines that must be fulfilled in order to receive approval as a biosimilar soluble insulin. Prescribers should therefore consider…
Immunological Monitoring to Rationally Guide AAV Gene Therapy
2013
Recent successes with adeno-associated virus (AAV)-based gene therapies fuel the hope for new treatments for hereditary diseases. Pre-existing as well as therapy-induced immune responses against both AAV and the encoded transgenes have been described and may impact on safety and efficacy of gene-therapy approaches. Consequently, monitoring of vector- and transgene-specific immunity is mandated and may rationally guide clinical development. Next to the humoral immune response, the cellular response is central in our understanding of the host reaction in gene therapy. But in contrast to the monitoring of antibodies, which has matured over many decades, sensitive and robust monitoring of T cel…
Digital game-based training of early reading skills : overview of the GraphoGame method in a highly transparent orthography / Entrenamiento de habili…
2014
Learning to read in a language with a transparent orthography is generally quick and easy. To be able to read any words, learners need to know how to connect the smallest spoken language units, phonemes, into the written counterparts, graphemes. However, even learning the basic alphabetic principle has proven difficult for some learners. Here we focus on children who struggle to learn to read in Finnish that has a highly transparent orthography. In an attempt to provide efficient early preventative support for such learners, a technologyenhanced learning environment, GraphoGame, was developed. The GraphoGame method focuses on the specific problematic areas of each individual learner using a…
Pharmacogenomics in psychiatry: from therapeutic drug monitoring to genomic medicine.
2013
Psychiatry is increasingly combining new pharmacogenomic findings with therapeutic drug monitoring (TDM) to improve the safety and efficacy of pharmacotherapy. However, a distinction should be made between “nice to know” and “need to know” pharmacogenomic data because many results are statistically significant in meta-analyses but are not clinically relevant due to their low effect sizes. Some examples will illustrate this integration.
COVID-19 y enfermedad cardiovascular y renal: ¿Dónde estamos? ¿Hacia dónde vamos?
2020
La pandemia SARS-CoV-2 es una emergencia sanitaria global y necesitamos conocer más sobre ella. Los pacientes con riesgo cardiovascular y renal previo se han identificado como especialmente vulnerables para una mayor morbimortalidad cuando sufren la COVID-19, y una proporción considerable de pacientes pueden desarrollar una lesión vascular en el contexto de la enfermedad que conlleva una mayor letalidad. Las complicaciones cardiovasculares y renales representan un problema, y es probable que en un futuro próximo puedan suponer una amenaza para los pacientes que han sobrevivido a la COVID-19. Como médicos no podemos olvidar que durante una epidemia como esta otras enfermedades ----crónicas--…