Search results for "Negative"
showing 10 items of 1052 documents
3D reconstruction of the hemocyanin subunit dimer from the chiton Acanthochiton fascicularis.
2004
Procedures are presented for the purification of the subunit dimer from Acanthochiton fasicularis hemocyanin. Electron microscopy of negatively stained specimens revealed a uniform population of macromolecules possessing the characteristic "boat shape". A 3D reconstruction from this EM data generated a approximately 3 nm resolution model that correlates well with earlier data of the purported subunit dimer, extracted from the 3D reconstruction of the didecamer of Haliotis tuberculata hemocyanin type 1.
Application of the Wood model to lactation curves of Comisana sheep
1997
Abstract Ninety-two ewes of the Comisana breed were used in a study to verify the forecasting capacity of the mathematical model proposed by Wood for fitting sheep data, and to evaluate the effect of the environmental factors affecting the parameters of the lactation curve. The Wood model underestimated the total lactation milk production with an error margin of 12.2 ± 7.8 kg of milk corresponding to 10.9 ± 6.6%. There was a strong influence of order of lambing × lambing season interaction on the lactation parameters. The curves for the winter lambing ewes demonstrated a higher peak production than autumn lambing ewes (1728.4 vs. 1082.6 g, P ≤ 0.05 for the second lambing ewes and 1772.8 vs.…
Can NF-κB Be Considered a Valid Drug Target in Neoplastic Diseases? Our Point of View
2020
Multidrug resistance (MDR), of the innate and acquired types, is one of major problems in treating tumor diseases with a good chance of success. In this review, we examine the key role of nuclear factor-kappa B (NF-κB) to induce MDR in three tumor models characterized precisely by innate or acquired MDR, in particular triple negative breast cancer (TNBC), hepatocellular carcinoma (HCC), and acute myeloid leukemia (AML). We also present different pharmacological approaches that our group have employed to reduce the expression/activation of this transcriptional factor and thus to restore chemo-sensitivity. Finally, we examine the latest scientific evidence found by other groups, the most sign…
Detection of 9-Tetrahydrocannabinol and Amphetamine-Type Stimulants in Oral Fluid Using the Rapid Stat Point-of-Collection Drug-Testing Device
2010
The Rapid Stat assay, a point-of-collection drug-testing device for detection of amphetamines, cannabinoids, cocaine, opiates, methadone, and benzodiazepines in oral fluid, was evaluated for cannabis and amphetamine-type stimulants. The Rapid Stat tests (n = 134) were applied by police officers in routine traffic checks. Oral fluid and blood samples were analyzed using gas chromatography-mass spectrometry (GC-MS) for Delta(9)-tetrahydrocannabinol, amphetamine, methamphetamine, methylenedioxymethamphetamine, methylenedioxyethylamphetamine, and methylenedioxyamphetamine. The comparison of GC-MS analysis of oral fluid with the Rapid Stat results for cannabis showed a sensitivity of 85%, a spec…
Protective and Risk Factors for Adolescent Substance Use in Spain: Self-Esteem and Other Indicators of Personal Well-Being and Ill-Being
2020
Although self-esteem has traditionally been considered as an important correlate of psychosocial adjustment, some empirical studies have found a positive relationship between some domains of self-esteem and drug use among adolescents. The present study analyzes self-esteem and other adjustment personal indicators as protective or risk factors for substance use. Participants were 644 Spanish adolescents aged 12&ndash
Traits and emotions
2000
This paper reviews literature on traits and emotions focusing on both structure and management, or 'having' and 'doing'. The cognitive perspective of this paper implies that traits and emotions are viewed as provisions to frame people and their behaviours in situations in meaningful ways. The focus on the structure of traits thus implies considering the now broadly acknowledged Big Five model as a dimensional framework by which traits of people can be meaningfully organized. A similar position is taken with respect to emotions, given the recurrent finding of a two-dimensional model of emotions with Positive Affect and Negative Affect (PA and NA). Maintaining relevant distinctions between tr…
Bank competition and multimarket contact intensity
2021
Abstract This paper analyzes the effect of multimarket contact on bank competition. We propose a completely new multimarket contact indicator that not only considers the existence of contacts between banks, but also their intensity, by analyzing the strength–weakness position of banks in terms of branch numbers in comparison to their rivals in the markets where they coincide. We test the new indicator empirically in the context of the Spanish banking sector. The main results suggest a negative relationship between market power and the number of multimarket contacts, rejecting the hypothesis of tacit collusion in the Spanish banking sector. However, the result changes completely when we cons…
A Spatiotemporal Solution for the Simultaneous Sale Price and Time-on-the-Market Problem
2015
There exists an important methodological challenge when dealing with sale price and time-on-the-market variables because both variables are simultaneously determined and related to the motivation of the sellers and buyers. Exploiting the fact that transactions occur over space and time, we propose a two-stage approach based on instrumental variables (IV) built from information collected from previous transactions. The unidirectional temporal property and the fact that other transactions are exogenous from the perspective of a single buyer or seller are exploited to evaluate the effect of the sale price on time-on-the-market, and the effect of time-on-the-market on the sale price. Based on 2…
Does the composition of regional knowledge bases influence extra-regional collaboration for innovation?
2013
There is a growing research interest in the relationship between the composition of regional knowledge bases and the extra-regional collaborative ties maintained by actors during their development work. To investigate this relationship, we use patent data to characterize European NUTS 3 regions by their (i) comparative technological specializations; and (ii) related technological variety. We find domestic, extra-regional collaboration to be negatively associated with regional technological specialization and related technological variety. At the same time, we find related technological variety to serve in support of international innovation collaboration.
TERRORISM AND INTERNATIONAL TOURISM: NEW EVIDENCE
2008
This paper analyses the impact of terrorist activity on international tourist flows. To this end, we have estimated a cross‐sectional gravity equation for tourism from the G‐7 countries to a sample of 134 destinations over the period 2001–2003. Within this framework, we evaluate the deviation from ‘normal’ tourist flows due to terrorist activity, which is considered as negative advertising for the affected country. The analysis suggests that both domestic victims and international attacks are relevant factors when foreign tourists make their choice. This result is robust under alternative specifications. Moreover, the impact of terrorism is more severe in developing countries. The author is…