Search results for "Neste"
showing 10 items of 639 documents
Chemie an starren Grenzflächen, 10. Kinetisches Verhalten einiger an „Isothiocyanato-Aerosil” immobilisierter Esterasen – Analogversuche mit Insulin
1988
Amino-Aerosil wird mit Thiophosgen nach Gl. (1) in Isothiocyanato-Aerosil 2 (NCS-Aerosil) ubergefuhrt. Trypsin, Cholinesterase und Acetylcholinesterase werden an 2 nach Gl. (2) immobilisiert. Die Aktivitat der immobilisierten Esterasen wird untersucht auf (a) Lagerstabilitat, (b) Temperaturbestandigkeit und (c) pH-Abhangigkeit. Das kinetische Verhalten der immobilisierten Enzyme wird verglichen mit dem der freien, aber mit n-Butylisothiocyanat behandelten Esterasen. Am Beispiel der Cholinesterase, die uber unterschiedliche Ankergruppen mit Aerosil verknupft wurde, wird der Einflus unterschiedlicher Spacergruppen auf die Hydrolysegeschwindigkeit studiert. Aerosile, die mit Acetylcholin-Analo…
Acetylcholine esterase: the structure.
1991
Biochemical Characterization of an Acetylcholine-hydrolyzing Enzyme from Bean Seedlings.
1980
An acetylcholine hydrolyzing enzyme was prepared and purified (40 times) from dwarf bean hypocotyl hooks. The purity of the enzyme was proved by polyacrylamide gel electrophoresis. The molecular weight of the enzyme was determined to be 65,000 daltons. Enzyme activity was the highest at pH 8.0 and between 30 and 36 C. The enzyme had an apparent affinity constant (K(m)) for acetylcholine of 460/micromolar. The affinity for substrate analogs increased from butyrylthiocholine to propionylthiocholine to acetylthiocholine. The enzyme activity was inhibited by choline, neostigmine, physostigmine, manganese, and calcium. Magnesium had no influence on the enzyme activity. We conclude that the enzym…
ChemInform Abstract: Synthetic Approaches Towards Huperzine A and B
2015
Huperzine A and B are potent acetylcholinesterase inhibitors and promising against Alzheimer's disease. Completed and formal total syntheses of these medically relevant alkaloids are presented and discussed.
(±)- BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channe…
2021
Multitarget-directed ligands (MTDLs) are considered a promising therapeutic strategy to address the multifactorial nature of Alzheimer's disease (AD). Novel MTDLs have been designed as inhibitors of human acetylcholinesterases/butyrylcholinesterases, monoamine oxidase A/B, and glycogen synthase kinase 3β and as calcium channel antagonists via the Biginelli multicomponent reaction. Among these MTDLs, (±)-BIGI-3h was identified as a promising new hit compound showing in vitro balanced activities toward the aforementioned recognized AD targets. Additional in vitro studies demonstrated antioxidant effects and brain penetration, along with the ability to inhibit the aggregation of both τ protein…
Cirugía ambulatoria: estudio de la morbilidad tardía
2022
La cirugía ambulatoria es una actividad rutinaria de la mayoría de los hospitales de nuestro país. Su implantación y desarrollo en los últimos años ha supuesto una solución para los grandes retos de la asistencia sanitaria actual, permitiendo reducir considerablemente la lista de espera quirúrgica bajo criterios de calidad, eficiencia y seguridad. Uno de los aspectos con mayor oportunidad de mejora es el control postoperatorio domiciliario en la fase tardía de la recuperación, especialmente más allá de las 24 horas tras la intervención. El método más utilizado actualmente en España para la evaluación del estado domiciliario es la entrevista telefónica estandarizada. Esta herramienta es útil…
Criteria for selecting children with special needs for dental treatment under general anaesthesia
2007
Objective: To study criteria for helping to select children with special needs for dental treatment under general anaesthesia. Materials and methods: Group of 30 children (aged under 18) examined on the Course at the Universidad Complutense de Madrid (UCM) (Specialisation on holistic dental treatment of children with special needs) and subsequently referred to the Disabled Children’s Oral Health Unit (DCOHU) within Primary Health Care Area 2 of the Madrid Health Service (SERMAS) where dental treatment under general anaesthesia was given during 2005. Relevant data were taken from their case histories with regard to their general health, oral health and behaviour. Results: In most of the chil…
valve prosthesis-patient mismatch: hemodynamic, echocardiografic and clinical evidences
2010
Species–area relationships in continuous vegetation: Evidence from Palaearctic grasslands
2019
Aim Species-area relationships (SARs) are fundamental scaling laws in ecology although their shape is still disputed. At larger areas, power laws best represent SARs. Yet, it remains unclear whether SARs follow other shapes at finer spatial grains in continuous vegetation. We asked which function describes SARs best at small grains and explored how sampling methodology or the environment influence SAR shape. Location Palaearctic grasslands and other non-forested habitats. Taxa Vascular plants, bryophytes and lichens. Methods We used the GrassPlot database, containing standardized vegetation-plot data from vascular plants, bryophytes and lichens spanning a wide range of grassland types throu…
Anestēzijas māsu veselību ietekmējošie darba vides riska faktori
2019
Bakalaura darbs “ Anestēzijas māsu veselību ietekmējošie darba vides riska faktori.”. Kaitīgie un bīstamie darba apstākļi vidējā medicīnas personāla vidū anestēzijas un reanimācijas nodaļā, pirmkārt, ir saistīti ar tiešo kontaktu ar infekcioziem aģentiem, medikamentu, ķīmiski agresīvo vielu un stresa nelabvēlīgu ietekmi uz organismu un tā sistēmām. Anestēzijas māsu darba spektrs ir ļoti plašs. Anestēzijas māsas ikdienā darbojās ne tikai operāciju blokā, veicot anestēziju pacientiem, bet arī strādā intensīvā terapijas nodaļā, reanimācijā un veic anestēziju dažāda veidā izmeklējumos. Tas liecina par to, ka māsas darba vide ir ļoti mainīga, un tādēļ māsas tiek pakļautas dažādiem riska faktorie…