Search results for "NeuroD"
showing 10 items of 604 documents
Reproducibility of Brain Responses: High for Speech Perception, Low for Reading Difficulties
2019
Neuroscience findings have recently received critique on the lack of replications. To examine the reproducibility of brain indices of speech sound discrimination and their role in dyslexia, a specific reading difficulty, brain event-related potentials using EEG were measured using the same cross-linguistic passive oddball paradigm in about 200 dyslexics and 200 typically reading 8–12-year-old children from four countries with different native languages. Brain responses indexing speech and non-speech sound discrimination were extremely reproducible, supporting the validity and reliability of cognitive neuroscience methods. Significant differences between typical and dyslexic readers were fou…
Preventive Impact of Long-Term Ingestion of Chestnut Honey on Glucose Disorders and Neurodegeneration in Obese Mice
2022
The purpose of the present study was to evaluate the impact of long-term honey ingestion on metabolic disorders and neurodegeneration in mice fed a high-fat diet (HFD). Three groups of mice were fed with a standard diet (STD), HFD or HFD supplemented with honey (HFD-H) for 16 weeks. Biochemical, histological, Western blotting, RT-PCR and Profiler PCR array were performed to assess metabolic parameters, peripheral and central insulin resistance and neurodegeneration. Daily honey intake prevented the HFD-induced glucose dysmetabolism. In fact, it reduced plasma fasting glucose, insulin and leptin concentrations and increased adiponectin levels. It improved glucose tolerance, insulin sensitivi…
Design, Synthesis and Evaluation of Fluorescent Analogues of Abscisic Acid
2020
A fluorescent analogue of abscisic acid has been prepared by combining (S)‐abscisic acid (ABA) with nitrobenzoxadiazole (NBD) fluorophore using ethanol amine as a linker. Isomerization of the double bond at the side chain of abscisic acid happened during the synthesis. The resulting fluorophore analogues derived from both isomeric compounds entered cells suggesting a wide applicability of the ABA‐NBD conjugates as fluorescent probes to study ABA mechanism of action. The functional properties of the isomeric ABA‐NBD conjugates were tested in vitro, by measuring TNFα expression and nitrite concentration in LPS‐stimulated macrophages and compared with their non‐fluorescent ABA isomers. Rationa…
p73 deficiency results in impaired self renewal and premature neuronal differentiation of mouse neural progenitors independently of p53
2010
10 p.-5 fig.
Neurodidattica teatrale e la performance dell'apprendimento
2021
La Neurodidattica, o Neuroeducation, innestata nel campo della Neuropsicologia infantile, si colloca tra la Neurobiologia e le Scienze dell'educazione: la prima si basa sul principio per cui ogni apprendimento determina un cambiamento nel cervello, dato che le reti neurali subiscono alcune modifiche; le Scienze dell'educazione hanno come obiettivo quello di creare strategie e metodologie didattiche sempre più efficaci. L'incontro tra Neurodidattica e prassi teatrale genera un ripensamento di alcuni aspetti del processo di insegnamento apprendimento, quali la cognizione, l emozione, l espressività emotiva, i registri della comunicazione, con un esercizio significativo di quelle aree encefali…
A Dual Role for Hyperbaric Oxygen in Stroke Neuroprotection: Preconditioning of the Brain and Stem Cells
2018
Stroke continues to be an extremely prevalent disease and poses a great challenge in developing safe and effective therapeutic options. Hyperbaric oxygen therapy (HBOT) has demonstrated significant pre-clinical effectiveness for the treatment of acute ischemic stroke, and limited potential in treating chronic neurological deficits. Reported benefits include reductions in oxidative stress, inflammation, neural apoptosis, and improved physiological metrics such as edema and oxygen perfusion, all of which contribute to improved functional recovery. This pre-clinical evidence has failed to translate into an effective evidence-based therapy, however, due in large part to significant inconsistenc…
Periodontitis and alzheimer´s disease
2020
Background Alzheimer's disease (AD), the main cause of dementia in the adult population, is characterized by a progressive loss of cognitive function. It is considered that neuroinflammation plays a fundamental role in its onset and progression. The bacteria present in the disbiotic microbiome generated during the course of periodontitis (PE) are capable of inducing a systemic inflammatory response, exacerbating the production of proinflammatory mediators that have the potential to spread to the systemic circulation. Material and Methods A literature review was made using the databases Scielo, PubMed, EBSCO and key words "Alzheimer disease", "Periodontitis", "Neurodegeneration", "Inflammati…
Distribución y dinámica de la prolil-oligopeptidasa (prep) en la neurona y su relación con la diferenciación, maduración, envejecimiento y neurodegen…
2012
La enzima Prolil-oligopeptidasa (PREP) es una enzima que, a diferencia de muchas peptidasas, es capaz de cortar resíduos de prolina. El hecho de que sea una enzima que se ha conservado desde el último ancestro común a todas las formas de vida, que se encuentre en grandes cantidades en el cerebro, que utilice como sustratos péptidos relacionados con el aprendizaje y la memoria y que sus inhibidores sean capaces de revertir la pérdida de memoria en ratones con daño neuronal, han hecho que esta enzima sea objeto de numerosos estudios a fin de esclarecer cuál es su función en el cerebro y si sus inhibidores podrían ser posibles agentes terapéuticos, en un futuro, en el tratamiento o prevención …
Buone pratiche e strumenti di analisi per l’apprendimento, l’insegnamento e l’inclusione
2022
Il presente lavoro, nato in seno al progetto di ricerca “Best practices and tools of analysis in schools and community contexts: learning, teaching & inclusion”, avviato su fondi del Dipartimento SPPEFF dell’Università di Palermo, nel marzo 2019 e giunto alla sua seconda fase. La metodologia di ricerca utilizzata – perché ritenuta adeguata a perseguire le finalità fissate e a fornire una visione complessa ed articolata del fenomeno investigato – è stata quella del Mixed Method, con particolare riferimento all’Explanatory Design: Participant Selection Model di Creswell, Plano Clark, et al. (2003). L’«Explanatory Design is a two-phase mixed methods design. The overall purpose of this desi…