Search results for "Nod"

showing 10 items of 4007 documents

Behavioral and clinical characteristics of people receiving medical care for HIV infection in an outpatient facility in Sicily, Italy

2016

Paola Di Carlo,1 Giuliana Guadagnino,1 Palmira Immordino,1 Giovanni Mazzola,2 Pietro Colletti,2 Ilenia Alongi,1 Lucia Adamoli,1 Francesco Vitale,1 Alessandra Casuccio1 1Department of Sciences for Health Promotion and Mother-Child Care “G D’Alessandro”, University of Palermo, 2Department of Medicinal Clinics and Emerging Diseases, “Paolo Giaccone” Polyclinic University Hospital, Palermo, Italy Aim: The authors examined a cohort of HIV-positive outpatients at the AIDS Center of Palermo University in Italy in order to identify factors related to the frequency of their visits to the outpatient facility for health care services.Methods: Two hundr…

0301 basic medicinemedicine.medical_specialtyMultivariate analysisSettore MED/17 - Malattie Infettivehard-to-reach groups030106 microbiologyHuman immunodeficiency virus (HIV)Medicine (miscellaneous)HIV Outpatient Servicemedicine.disease_causeSettore MED/42 - Igiene Generale E Applicata03 medical and health sciences0302 clinical medicineOutpatient facilityAmbulatory careAcquired immunodeficiency syndrome (AIDS)CD4+ T-cell countHealth careMedicine030212 general & internal medicinePharmacology Toxicology and Pharmaceutics (miscellaneous)Access to care; CD4+ T-cell count; Hard-to-reach groups; HIV infection; HIV outpatient service; Resource use; Social Sciences (miscellaneous); Medicine (miscellaneous); Health Policy; Pharmacology Toxicology and Pharmaceutics (miscellaneous)Original Researchaccess to carelcsh:R5-920business.industryHealth PolicyUnivariatemedicine.diseaseHIV infectionresource usePatient Preference and AdherenceEmergency medicineCohortbusinesslcsh:Medicine (General)Hard-to-reach groupSocial Sciences (miscellaneous)
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Anatomical Variations in the Sinoatrial Nodal Artery: A Meta-Analysis and Clinical Considerations

2016

Background and Objective The sinoatrial nodal artery (SANa) is a highly variable vessel which supplies blood to the sinoatrial node (SAN). Due to its variability and susceptibility to iatrogenic injury, our study aimed to assess the anatomy of the SANa and determine the prevalence of its anatomical variations. Study Design An extensive search of major electronic databases was performed to identify all articles reporting anatomical data on the SANa. No lower date limit or language restrictions were applied. Anatomical data regarding the artery were extracted and pooled into a meta-analysis. Results Sixty-six studies (n = 21455 hearts) were included in the meta-analysis. The SANa usually aros…

0301 basic medicinemedicine.medical_specialtyPopulation Dynamicslcsh:MedicineCoronary Artery Disease030204 cardiovascular system & hematologyResearch and Analysis MethodsVascular MedicineCoronary artery diseaseDatabase and Informatics Methods03 medical and health sciencesMathematical and Statistical Techniques0302 clinical medicinemedicine.arteryInternal medicineMedicine and Health SciencesmedicineStatistical MethodsDatabase SearchingPulmonary Arterieslcsh:ScienceSinoatrial nodal arteryCoronary ArteriesMultidisciplinaryPopulation BiologySinoatrial nodebusiness.industryIatrogenic injurylcsh:RBiology and Life SciencesArteriesmedicine.diseaseGeographic DistributionCoronary arteriesGeographic distributionmedicine.anatomical_structureMeta-analysisPhysical SciencesCardiovascular AnatomyCardiologyBlood Vesselslcsh:Q030101 anatomy & morphologyAnatomybusinessMathematicsStatistics (Mathematics)Research ArticleMeta-AnalysisPLOS ONE
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Is there any therapeutic role of pelvic and para-aortic lymphadenectomy in apparent early stage epithelial ovarian cancer?

2020

Objective: The therapeutic role of pelvic and para-aortic lymphadenectomy in surgical staging of apparent early-stage epithelial ovarian cancer (eEOC) is still under debate. The aim of this study was to evaluate the potential therapeutic role of systematic lymphadenectomy in patients with eEOC. Methods: Multi-center retrospective cohort study, comparing women with apparent eEOC who underwent comprehensive bilateral pelvic and para-aortic lymphadenectomy (defined as ≥20 lymph nodes) versus patients receiving no lymphadenectomy or lymph node sampling, from 05/1985 to 12/2016. Patients with bulky nodes at CT-scan and those without complete intra-peritoneal surgical staging were excluded. Only …

0301 basic medicinemedicine.medical_specialtyPrognosimedicine.medical_treatmentEarly-stageLymph node samplingCarcinoma Ovarian EpithelialDisease-Free SurvivalPelvisLymph node samplingCohort StudiesSurgical staging03 medical and health sciences0302 clinical medicineOvarian cancerMedicineHumansEpithelial ovarian cancerStage (cooking)early-stage; lymph node sampling; lymphadenectomy; ovarian cancer; prognosis; surgical stagingNeoplasm StagingRetrospective StudiesOvarian NeoplasmsChemotherapybusiness.industryObstetrics and GynecologyRetrospective cohort studyLymphadenectomyMiddle Agedmedicine.diseaseSurvival RateSettore MED/40 - GINECOLOGIA E OSTETRICIA030104 developmental biologyOncology030220 oncology & carcinogenesisLymphatic MetastasisLymph Node ExcisionLymphadenectomyFemaleLymphRadiologyLymph NodesprognosisbusinessOvarian cancer
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Pathways of care for HIV infected children in Beira, Mozambique: pre-post intervention study to assess impact of task shifting

2018

Abstract Background In 2013, Mozambique implemented task-shifting (TS) from clinical officers to maternal and child nurses to improve care for HIV positive children < 5 years old. A retrospective, pre-post intervention study was designed to evaluate effectiveness of a new pathway of care in a sample of Beira District Local Health Facilities (LHFs), the primary, local, community healthcare services. Methods The study was conducted by accessing registries of At Risk Children Clinics (ARCCs) and HIV Health Services. Two time periods, pre- and post-intervention, were compared using a set of endpoints. Variables distribution was explored using descriptive statistics. T-student, Mann Whitney and …

0301 basic medicinemedicine.medical_specialtyReferralHIV InfectionsHIV infected childrenSettore MED/42 - Igiene Generale E ApplicataPost-intervention03 medical and health sciences0302 clinical medicineHIV exposed infants; HIV infected children; Human immunodeficiency virus; Paediatric HIV care and treatment; Pathways of care; Task-shiftingIntervention (counseling)EpidemiologyHealth caremedicineHumansHealth Workforce030212 general & internal medicineHuman immunodeficiency viruReferral and ConsultationMozambiqueRetrospective StudiesDescriptive statisticsbusiness.industryHuman immunodeficiency virusPublic healthlcsh:Public aspects of medicinePaediatric HIV care and treatmentPublic Health Environmental and Occupational HealthInfantHIV exposed infantlcsh:RA1-1270030112 virologyTask-shiftingHIV exposed infantsCD4 Lymphocyte CountChild PreschoolFamily medicineHealth Services ResearchBiostatisticsbusinessDelivery of Health CarePathways of careResearch ArticleBMC Public Health
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Association of Non-Invasive Markers of Liver Fibrosis with HCV Coinfection and Antiretroviral Therapy in Patients with HIV

2019

Abstract The aim of this study was to assess the main effects and interaction between viral hepatitis C (HCV) coinfection and antiretroviral therapy (ART) by using a nonparametric ANOVA on direct and indirect markers of liver fibrosis in HIV-infected patients. The sample included 178 HIV patients aged from 23 to 65 (36% females). The following parameters were determined in blood of patients: hyaluronic acid, pro-matrix metalloproteinase-1, alanine aminotransferase, aspartate aminotransferase, and platelet count. The FIB-4 index was also calculated. The nonparametric ANOVA revealed no significant interaction between HCV coinfection and ART. This provides evidence for an independent contribut…

0301 basic medicinemedicine.medical_specialtyfib-4Liver fibrosisScienceHuman immunodeficiency virus (HIV)medicine.disease_causeGastroenterologypro-mmp-103 medical and health sciences0302 clinical medicineInternal medicinehyaluronic acidmedicinePlateletliver fibrosisMultidisciplinaryaltNon invasiveQmedicine.disease030112 virologyAntiretroviral therapyCoinfection030211 gastroenterology & hepatologyAnalysis of variancenonparametric anovaViral hepatitisastProceedings of the Latvian Academy of Sciences. Section B, Natural Sciences
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Personalized vaccines for cancer immunotherapy

2018

Cancer is characterized by an accumulation of genetic alterations. Somatic mutations can generate cancer-specific neoepitopes that are recognized by autologous T cells as foreign and constitute ideal cancer vaccine targets. Every tumor has its own unique composition of mutations, with only a small fraction shared between patients. Technological advances in genomics, data science, and cancer immunotherapy now enable the rapid mapping of the mutations within a genome, rational selection of vaccine targets, and on-demand production of a therapy customized to a patient’s individual tumor. First-in-human clinical trials of personalized cancer vaccines have shown the feasibility, safety, and immu…

0301 basic medicinemedicine.medical_treatmentBioinformaticsmedicine.disease_causeCancer Vaccines03 medical and health sciences0302 clinical medicineCancer immunotherapyAntigens NeoplasmNeoplasmsmedicineHumansPrecision MedicineMutationMultidisciplinaryImmunodominant EpitopesCancerImmunotherapyPrecision medicinemedicine.diseaseVaccinationClinical trial030104 developmental biology030220 oncology & carcinogenesisMutationImmunotherapyCancer vaccineScience
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Preproinsulin designer antigens excluded from endoplasmic reticulum suppressed diabetes development in nod mice by dna vaccination

2019

DNA vaccines against autoimmune type 1 diabetes (T1D) contain a nonpredictable risk to induce autoreactive T cell responses rather than a protective immunity. Little is known if (and how) antigen expression and processing requirements favor the induction of autoreactive or protective immune responses by DNA immunization. Here, we analyzed whether structural properties of preproinsulin (ppins) variants and/or subcellular targeting of ppins designer antigens influence the priming of effector CD8+ T cell responses by DNA immunization. Primarily, we used H-2b RIP-B7.1 tg mice, expressing the co-stimulator molecule B7.1 in beta cells, to identify antigens that induce or fail to induce autoreacti…

0301 basic medicinepreproinsulin/proinsulin antigensPreproinsulinlcsh:QH426-470type 1 diabetesMouse ModelsBiologyMajor histocompatibility complexArticleDNA vaccinationDNA vaccines03 medical and health sciences0302 clinical medicineImmune systemAntigenImmunityGeneticsmouse models:Science::Medicine [DRNTU]lcsh:QH573-671Molecular BiologyNOD micelcsh:Cytologylcsh:Geneticsendoplasmic reticulum030104 developmental biology030220 oncology & carcinogenesisImmunologybiology.proteinType 1 DiabetesMolecular MedicineCD8
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The growing role of precision medicine for the treatment of autoimmune diseases; results of a systematic review of literature and Experts’ Consensus

2021

International audience; Autoimmune diseases (AIDs) share similar serological, clinical, and radiological findings, but, behind these common features, there are different pathogenic mechanisms, immune cells dysfunctions, and targeted organs. In this context, multiple lines of evidence suggest the application of precision medicine principles to AIDs to reduce the treatment failure. Precision medicine refers to the tailoring of therapeutic strategies to the individual characteristics of each patient, thus it could be a new approach for management of AIDS which considers individual variability in genes, environmental exposure, and lifestyle. Precision medicine would also assist physicians in ch…

0301 basic medicinerheumatoid arthritismedicine.medical_specialtyantiphospholipid syndrome; precision medicine; primary sjogren's syndrome; rheumatoid arthritis; spondyloarthritides; systemic lupus erythematosus; systemic sclerosis; consensus; humans; precision medicine; autoimmune diseases; lupus erythematosus systemic; sjogren's syndromeConsensusspondyloarthritidesystemic sclerosisImmunologysystemic lupus erythematosuSjogren's Syndrome.Context (language use)Consensuprimary Sjogren's syndromeAutoimmune DiseaseTreatment failureAutoimmune DiseasesNOEfficacy03 medical and health sciences0302 clinical medicineprimary Sjogren’s syndromeAcquired immunodeficiency syndrome (AIDS)systemic lupus erythematosusmedicineImmunology and AllergyHumansLupus Erythematosus SystemicIn patientIntensive care medicineAdverse effect030203 arthritis & rheumatologybusiness.industryPrecision medicinePrecision medicine; antiphospholipid syndrome; primary Sjogren’s syndrome; rheumatoid arthritis; spondyloarthritides; systemic lupus erythematosus; systemic sclerosisEnvironmental exposurerheumatoid arthritimedicine.diseasePrecision medicineantiphospholipid syndrome; Precision medicine; primary Sjogren's syndrome; rheumatoid arthritis; spondyloarthritides; systemic lupus erythematosus; systemic sclerosisspondyloarthritides3. Good health030104 developmental biologySjogren's Syndrome[SDV.IMM]Life Sciences [q-bio]/Immunologybusinesssystemic sclerosiantiphospholipid syndromeHuman
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Subnational mapping of HIV incidence and mortality among individuals aged 15-49 years in sub-Saharan Africa, 2000-18: a modelling study

2021

Background. High-resolution estimates of HIV burden across space and time provide an important tool for tracking and monitoring the progress of prevention and control efforts and assist with improving the precision and efficiency of targeting efforts. We aimed to assess HIV incidence and HIV mortality for all second-level administrative units across sub-Saharan Africa. Methods. In this modelling study, we developed a framework that used the geographically specific HIV prevalence data collected in seroprevalence surveys and antenatal care clinics to train a model that estimates HIV incidence and mortality among individuals aged 15–49 years. We used a model-based geostatistical framework to e…

0301 basic medicinesub-Saharan AfricaMaleHIV AntibodieEpidemiologyHIV incidencesHIV Infectionsmortality rateHIV AntibodiesModelling studyHuman immunodeficiency virus prevalence0302 clinical medicineAfrica NorthernRA0421Seroepidemiologic StudiesMedicineNorthernHIV Infection030212 general & internal medicineYoung adult10. No inequalityuncertaintyMozambique11 Medical and Health SciencesHIV mortalityMortality rateIncidence (epidemiology)Incidence1. No povertyHiv incidencearticleMauritaniaHuman immunodeficiency virus infected patientArticlestrackingMiddle Agedhealth care planning3. Good healthPeer reviewLesothoAIDSInfectious DiseasesQR180A990 Medicine and Dentistry not elsewhere classifiedFemaleprenatal careanti human immunodeficiency virus agentseroepidemiologyHumanAdultAdolescentAnti-HIV AgentsImmunologyantiretroviral therapyUnit (housing)03 medical and health sciencesYoung AdultbloodHuman immunodeficiency virus infectionVirologySeroprevalenceHumanshumanDeveloping CountriesEstimationAcquired Immunodeficiency SyndromeSubnational mappingsbusiness.industrySeroepidemiologic StudieHIVAnti-HIV AgentPREVENTION030112 virologymortalitymonitoring3121 General medicine internal medicine and other clinical medicineHuman immunodeficiency virus antibodyAfricabusinessHIV incidence ; HIV mortality ; Subnational mapping ; Sub-Saharan Africa ; Local burden of disease ; Public healthDemography
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More than a pore: How voltage-gated calcium channels act on different levels of neuronal communication regulation.

2021

ABSTRACT Voltage-gated calcium channels (VGCCs) represent key regulators of the calcium influx through the plasma membrane of excitable cells, like neurons. Activated by the depolarization of the membrane, the opening of VGCCs induces very transient and local changes in the intracellular calcium concentration, known as calcium nanodomains, that in turn trigger calcium-dependent signaling cascades and the release of chemical neurotransmitters. Based on their central importance as concierges of excitation-secretion coupling and therefore neuronal communication, VGCCs have been studied in multiple aspects of neuronal function and malfunction. However, studies on molecular interaction partners …

0301 basic medicineα2δ subunitsBiophysicschemistry.chemical_elementReviewNeurotransmissionCalciumBiochemistrySynaptic TransmissionCalcium in biology03 medical and health sciencesvoltage-induced calcium releasealternative splicing0302 clinical medicinevoltage-gated calcium channelsCavβ subunitsVGCC auxiliary subunitsCalcium SignalingIon channelNeuronssynaptogenesisVoltage-dependent calcium channelChemistryRyanodine receptorDepolarization030104 developmental biologyIon channelsCalciumgene regulationNeuroscience030217 neurology & neurosurgeryIntracellularResearch ArticleChannels (Austin, Tex.)
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