Search results for "Node"

Functional Signatures of Human CD4 and CD8 T Cell Responses to Mycobacterium tuberculosis

2014

With 1.4 million deaths and 8.7 million new cases in 2011, tuberculosis (TB) remains a global health care problem and together with HIV and Malaria represents one of the three infectious diseases world-wide. Control of the global TB epidemic has been impaired by the lack of an effective vaccine, by the emergence of drug-resistant forms of Mycobacterium tuberculosis (Mtb) and by the lack of sensitive and rapid diagnostics. It is estimated, by epidemiological reports, that one third of the world's population is latently infected with Mtb, but the majority of infected individuals develop long-lived protective immunity, which controls and contains Mtb in a T cell-dependent manner. Development o…

Alternative UNC13D Promoter Encodes a Functional Munc13-4 Isoform Predominantly Expressed in Lymphocytes and Platelets

2020

Autosomal recessive mutations in genes required for cytotoxicity are causative of a life-threatening, early-onset hyperinflammatory syndrome termed familial hemophagocytic lymphohistiocytosis (FHL). Mutations in UNC13D cause FHL type 3. UNC13D encodes Munc13-4, a member of the Unc13 protein family which control SNARE complex formation and vesicle fusion. We have previously identified FHL3-associated mutations in the first intron of UNC13D which control transcription from an alternative transcriptional start site. Using isoform specific antibodies, we demonstrate that this alternative Munc13-4 isoform with a unique N-terminus is preferentially expressed in human lymphocytes and platelets, as…

A Self-Contained and Automated Method for Flood Hazard Maps Prediction in Urban Areas

2020

Water depths and velocities predicted inside urban areas during severe storms are traditionally the final result of a chain of hydrologic and hydraulic models. The use of a single model embedding all the components of the rainfall&ndash

Preliminary analysis of CH3D from 3250 to 3700 cm(-1)

2006

International audience; The infrared spectrum of CH3D from 3250 to 3700 cm(-1) was studied for the first time to assign transitions involving the nu(2) + nu(3), nu(2) + nu(5), nu(2) + nu(6), nu(3) + 2(nu 6) and 3 nu(6) vibrational states. Line positions and intensities were measured at 0.011 cm(-1) resolution using Fourier transform spectra recorded at Kitt Peak with isotopically enriched samples. Some 2852 line positions (involving over 900 upper state levels) and 874 line intensities were reproduced with RMS values of 0.0009 cm(-1) and 4.6%, respectively. The strongest bands were found to be nu(2) + nu(3) at 3499.7 cm(-1) and nu(2) + nu(6) at 3342.5 cm(-1) with integrated strengths, respe…

The sonographic pattern of neck lymph nodes in chronic autoimmune thyroiditis.

2013

Background: Neck lymph nodes may be involved in the pathogenesis of chronic autoimmune thyroiditis (CAT).We hypothesized that the involvement of cervical lymph nodes in CAT may be associated with a different sonographic pattern of neck nodes in comparison to subjects without CAT. Methods: We included 106 patients (92 females and 14 males) with CAT and 70 control subjects (53 females andm17 males) without clinical, biochemical, and ultrasonographic evidence of thyroid and neck diseases. We performed laboratory tests (thyrotropin, antithyroperoxidase antibodies, antithyroglobulin antibodies, and ultrasonography) to evaluate in each group: (i) thyroid function, autoimmunity, and morphology; (i…

main routes of trasmission of human immunodeficiency virus (HIV) infection in a family setting in Palermo: some biological properties of the new isol…

1989

Selective uptake of naked vaccine RNA by dendritic cells is driven by macropinocytosis and abrogated upon DC maturation.

2011

Even though it is known for more than one decade that antigen-encoding RNA can deliver antigenic information to induce antigen-specific immunity against cancer, the nature and mechanism of RNA uptake have remained enigmatic. In this study, we investigated the pharmacokinetics of naked RNA administered into the lymph node. We observed that RNA is rapidly and selectively uptaken by lymph node dendritic cells (DCs). Furthermore, in vitro and in vivo studies revealed that the efficient internalization of RNA by human and murine DCs is primarily driven by macropinocytosis. Selective inhibition of macropinocytosis by compounds or as a consequence of DC maturation abrogated RNA internalization and…

Clinical profile associated with HIV risk in Spanish youth

2018

Heterosexual transmission is the second route of new HIV infection diagnoses in Spain. A high percentage of young people use condom inconsistently. Beyond cognitive factors, emotional variables seem to be associated with sexual risk behavior. The aim was to examine the differential clinical profile between young people at risk and no-risk for HIV infection. A total of 424 heterosexuals were evaluated (M age =20.62; SD=2.16), and distributed into two groups: risk group (60.7%) and non-risk group (39.3%). They completed the AIDS Prevention Questionnaire, the Beck Depression Inventory, the Rosenberg Self-Esteem Scale, the Penn State Worry Questionnaire, and the Brief Fear of Negative Evaluatio…

Development of Gut-Associated Lymphoid Tissues

2015

The intestinal mucosa is one of our largest and most exposed body surfaces, thus creating a vital need for efficient immune responses. In order to coordinate those, the mucosal immune system comprises several organized lymphoid structures; the best-studied ones are mesenteric lymph nodes, Peyer’s patches, cryptopatches, and isolated lymphoid follicles. Their developmental requirements and time frames overlap to a certain extent, but are greatly divergent in many aspects. Furthermore, they can be influenced by a number of environmental impacts, such as food or the intestinal microbiota. In the following chapter we will try to shed some light on the processes that occur during the development…

On the anti-inflammatory and anti-phospholipase A2 activity of extracts from lanostane-rich species

2000

Abstract We have studied extracts from three species rich in lanostane triterpenes for their activity against different in vivo models of inflammation induced by TPA, EPP and PLA2. The inhibitory effect against PLA2 in vitro was also studied. When the Poria cocos extract was tested against PLA2-induced mouse paw edema, it was active by the oral and parenteral routes. Its effect was greater in both magnitude and duration than that of Pistacia terebinthus and Ganoderma lucidum extracts. P. terebinthus was effective against chronic and acute inflammation, and according to a preliminary chromatographic analysis, its seems to be a good source of lanostane anti-inflammatory agents. G. lucidum was…