Search results for "Norpregnenes"

showing 3 items of 3 documents

Binding of oral contraceptive progestogens to serum proteins and cytoplasmic receptor

1990

Abstract Some progestogens widely used in oral contraceptives are characterized at the level of high-affinity receptor binding as well as binding to sex hormone-binding globulin and corticosteroid-binding globulin. With regard to binding to sex hormone-binding globulin, gestodene, levonorgestrel, and to a lesser extent 3-ketodesogestrel (which is only formed from the prodrug desogestrel in the body), show a behavior that is manifested in the relatively high affinity to sex hormone-binding globulin, whereas desogestrel and norgestimate do not display any measurable affinity for this specific steroid-binding serum protein. Furthermore, levonorgestrel and gestodene dissociate very much more sl…

MaleCytoplasmmedicine.medical_specialtyNorpregnenesmedicine.medical_treatmentReceptors Cell SurfaceLevonorgestrelCytoplasmic receptorGestodeneBinding CompetitiveContraceptives Oral HormonalSex hormone-binding globulinPregnancyDesogestrelSex Hormone-Binding GlobulinInternal medicineNorgestrelmedicineAnimalsHumansLevonorgestrelProgesteroneTranscortinDesogestrelProgesterone CongenersProgestogenbiologybusiness.industryNorgestrelUterusObstetrics and GynecologyRats Inbred StrainsBlood ProteinsNorgestimateRatsKineticsEndocrinologybiology.proteinFemaleProgestinsbusinesshormones hormone substitutes and hormone antagonistsmedicine.drugAmerican Journal of Obstetrics and Gynecology
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Lack of binding of gestodene to estrogen receptor in human breast cancer tissue

1990

Competition studies with progesterone and estradiol receptors of human myometrial tissue as well as of mammary cancer tissue showed that gestodene bound with high affinity to the progesterone receptor, as did other synthetic and natural progestogens. However, gestodene did not bind to the estradiol receptor. The relative binding affinities of all tested synthetic and natural ligands showed no organ-specific differences and no differences between neoplastically transformed and normal tissues.

medicine.medical_specialtyNorpregnenesNormal tissueEstrogen receptorBreast NeoplasmsIn Vitro TechniquesBiologyGestodeneBinding CompetitivePromegestoneInternal medicineProgesterone receptormedicineHumansReceptorBinding affinitiesProgesterone CongenersCancermedicine.diseaseEndocrinologyReceptors EstrogenOncologyMyometriumFemaleReceptors ProgesteroneHuman breasthormones hormone substitutes and hormone antagonistsmedicine.drugEuropean Journal of Cancer and Clinical Oncology
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Oral contraceptives in the prevention of endometrioma recurrence: does the different progestins used make a difference?

2013

""The primary aim of the study was to analyze the endometrioma recurrence rate in patients who underwent laparoscopic excision followed by postoperative long-term regimen of oral contraceptives (OCs).. . MATERIALS AND METHODS: 168 patients who underwent a conservative laparoscopic surgery for endometrioma, during the period between September 2009 and August 2010 in three university hospitals were studied. A long-term OCs therapy was offered to all women following surgery. Patients were randomly divided into three groups according to different progestins used (desogestrel, gestodene, dienogest). Women who refused a postoperative hormonal therapy served as control. Follow-up visits and transv…

minimally invasive gynecologic surgeryAdultmedicine.medical_specialtyEndometriosis endometrioma recurrencee oral contraceptives minimally invasive gynecologic surgery progestins dienogest.AdolescentNorpregnenesendometrioma recurrenceeEndometriosisEndometriosisKaplan-Meier EstimateDrug Administration Schedulelaw.inventionYoung Adultchemistry.chemical_compoundRandomized controlled triallawSecondary PreventionHumansNandroloneMedicineIn patientOvarian DiseasesYoung adultLaparoscopyoral contraceptivesDesogestrelmedicine.diagnostic_testbusiness.industryObstetricsObstetrics and GynecologyEndometriosis Endometrioma recurrence Oral contraceptives Minimally invasive gynaecologic surgery Progestins DienogestGeneral MedicineLaparoscopic excisionmedicine.diseaseCombined Modality TherapySurgeryRegimenTreatment OutcomeDienogestchemistryprogestinsdienogestFemaleLaparoscopybusinessContraceptives OralFollow-Up Studies
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