6533b86ffe1ef96bd12ce9bc
RESEARCH PRODUCT
Lack of binding of gestodene to estrogen receptor in human breast cancer tissue
B. ManzK. Schmidt-gollwitzerKunhard PollowW. ElgerM. JuchemS. BeierHans-jörg Grillsubject
medicine.medical_specialtyNorpregnenesNormal tissueEstrogen receptorBreast NeoplasmsIn Vitro TechniquesBiologyGestodeneBinding CompetitivePromegestoneInternal medicineProgesterone receptormedicineHumansReceptorBinding affinitiesProgesterone CongenersCancermedicine.diseaseEndocrinologyReceptors EstrogenOncologyMyometriumFemaleReceptors ProgesteroneHuman breasthormones hormone substitutes and hormone antagonistsmedicine.drugdescription
Competition studies with progesterone and estradiol receptors of human myometrial tissue as well as of mammary cancer tissue showed that gestodene bound with high affinity to the progesterone receptor, as did other synthetic and natural progestogens. However, gestodene did not bind to the estradiol receptor. The relative binding affinities of all tested synthetic and natural ligands showed no organ-specific differences and no differences between neoplastically transformed and normal tissues.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1990-01-01 | European Journal of Cancer and Clinical Oncology |