0000000001082818

AUTHOR

B. Manz

showing 2 related works from this author

Radioimmunoassay of Plasma and Urinary Norepinephrine

1989

Various analytical methods, such as fluorimetry, radioenzymic assay and in particular liquid chromatography are used for the analysis of norepinephrine (NA) in body fluids and tissue homogenates. These procedures, however, often lack sensitivity, are expensive and/or time consuming. Basing on our previous reports on the radioimmunoassay of chemically modified serotonin1, 5-hydroxy-3-indole acetic acid2 and normetanephrine (NMN)3, a sensitive radioimmunoassay of the N-acetyl,3-methoxy analogue of urinary and plasma norepinephrine was developed.

Norepinephrine (medication)chemistry.chemical_compoundChromatographyPlasma norepinephrineChemistryUrinary systemmedicineRadioimmunoassayNormetanephrinemedicine.drug
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Lack of binding of gestodene to estrogen receptor in human breast cancer tissue

1990

Competition studies with progesterone and estradiol receptors of human myometrial tissue as well as of mammary cancer tissue showed that gestodene bound with high affinity to the progesterone receptor, as did other synthetic and natural progestogens. However, gestodene did not bind to the estradiol receptor. The relative binding affinities of all tested synthetic and natural ligands showed no organ-specific differences and no differences between neoplastically transformed and normal tissues.

medicine.medical_specialtyNorpregnenesNormal tissueEstrogen receptorBreast NeoplasmsIn Vitro TechniquesBiologyGestodeneBinding CompetitivePromegestoneInternal medicineProgesterone receptormedicineHumansReceptorBinding affinitiesProgesterone CongenersCancermedicine.diseaseEndocrinologyReceptors EstrogenOncologyMyometriumFemaleReceptors ProgesteroneHuman breasthormones hormone substitutes and hormone antagonistsmedicine.drugEuropean Journal of Cancer and Clinical Oncology
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