Search results for "Nous"

Paleoenvironmental evolution of the Pliocene Villarroya Lake, northern Spain. A multidisciplinary approach

2002

The Pliocene Villarroya basin fill consists of lacustrine and alluvial deposits over 100 m thick. The lacustrine deposits, up to 30 m thick, comprise three sequences. The two lower sequences consist of profundal, laminated deposits formed by mostly terrigenous facies that are overlain by charophytic carbonates and varves. The uppermost, third sequence made up of massive bioturbated mudstones corresponds to a very shallow lacustrine-palustrine environment. Bulk mineralogy comprises carbonates, clay minerals, quartz and feldspars. The carbonates are: exogenic, biogenic calcite and biogenic aragonite. Biogenic calcite constitutes ostracod shells and charophyte stem encrustations, whereas arago…

Inhibition of activated STAT5 in Bcr/Abl expressing leukemia cells with new pimozide derivatives.

2014

STATs are transcription factors acting as intracellular signaling after stimulation with cytokines, growth factors and hormones. STAT5 is also constitutively active in many forms of cancers, including chronic myelogenous leukemia, acute lymphoblastic leukemia and Hodgkin's lymphoma. Recently, literature reported that the neuroleptic drug pimozide inhibits STAT5 phosphorylation inducing apoptosis in CML cells. We undertook an investigation from pimozide structure, obtaining simple derivatives with cytotoxic and STAT5-inhibitory activity, two of them markedly more potent than pimozide.

Risk factors associated with adverse events in neonates with peripherally inserted central catheter

2019

Abstract Background Peripherally inserted central catheters have become a priority in infants who require long-term intravenous therapy, but their use involves certain risks. Objective The aim of the study was to describe the occurrence of adverse events in newborns with peripherally inserted central catheters and to determine the risk factors associated with them. Methods A descriptive cross-sectional study was designed and performed. All neonates with peripherally inserted central catheters from October 1st, 2014 to September 30th, 2015 were included. The adverse events and sociodemographic and clinical variables related to neonates and analysed catheters were recorded. Results A total of…

Auditory cortical and hippocampal-system mismatch responses to duration deviants in urethane-anesthetized rats.

2013

Any change in the invariant aspects of the auditory environment is of potential importance. The human brain preattentively or automatically detects such changes. The mismatch negativity (MMN) of event-related potentials (ERPs) reflects this initial stage of auditory change detection. The origin of MMN is held to be cortical. The hippocampus is associated with a later generated P3a of ERPs reflecting involuntarily attention switches towards auditory changes that are high in magnitude. The evidence for this cortico-hippocampal dichotomy is scarce, however. To shed further light on this issue, auditory cortical and hippocampal-system (CA1, dentate gyrus, subiculum) local-field potentials were …

Collagenous spherulosis and adenoid-cystic carcinoma of the breast: immunohistochemistry and usefulness of CD10 and HHF35 actin

2011

Efficient gene delivery to the inflamed colon by local administration of recombinant adenoviruses with normal or modified fibre structure

1999

BACKGROUND/AIMSReplication deficient recombinant adenoviruses represent an efficient means of transferring genes in vivo into a wide variety of dividing and quiescent cells from many different organs. Although the gastrointestinal tract is a potentially attractive target for gene therapy approaches, only a few studies on the use of viral gene transfer vehicles in the gut have been reported. The prospects of using recombinant adenoviruses for gene delivery into epithelial and subepithelial cells of the normal and inflamed colon are here analysed.METHODSAn E1/E3 deleted recombinant adenovirus (denoted AdCMVβGal) and an adenovirus with modified fibre structure (denoted AdZ.F(pk7)) both express…

2-Cinnamamido, 2-(3-phenylpropiolamido), and 2-(3-phenylpropanamido)benzamides: synthesis, antiproliferative activity, and mechanism of action

2013

Abstract Several new benzamides 4a–q were synthesized by stirring in pyridine the acid chlorides 3a–q with the appropriate anthranilamide derivatives 2a–g. Some of the synthesized compounds were evaluated for their in vitro antiproliferative activity against a panel of 5 human cell lines (K562 human chronic myelogenous leukemia cells, MCF-7 breast cancer cells, HTC-116 and HT26 colon cancer cells and NCI H460 non-small cell lung cancer cells).

BARGAINING WITH COMMITMENT UNDER AN UNCERTAIN DEADLINE

2006

We consider an infinite horizon bargaining game in which a deadline can arise with positive probability and where players possess an endogenous commitment device. We show that for any truncation of the game, the equilibrium agreement can only take place if the deadline arises within this finite horizon. Since the deadline is an uncertain event, the equilibrium exhibits agreements which are delayed with positive probability.

Broadcasting Indigenous Voices

2008

Ethnic minority media embody much of the multiculturalist, multilingual and transnational changes in the media landscape and in the wider societal frame as well. Often minority media aim at providing relevant information, but also alternative publicity and empowering experiences in regard to their own identity, language and culture. Through an analysis of journalists' interviews and ethnographic data, this article examines how these tendencies, possibilities and limitations are played out in the indigenous Sami media. The findings suggest that the Sami journalists have managed to provide an alternative public space and contribute to linguistic revitalization. Yet, working within translocal …

Promoting multilingual communicative competence through multimodal academic learning situations

2016

This paper presents information on the factors affecting the development of multilingual and multicultural communicative competence in interactive multimodal learning environments in an academic context. The interdisciplinary course in multilingual interaction offered at the University of Jyväskylä aims to enhance students’ competence in multilingual and multicultural academic communication by promoting the use of their entire linguistic repertoire in various learning situations. Throughout the course, we observed the students’ engagement in multilingual and multicultural activities. These observations suggest that simultaneous use of multiple languages in synchronous and asynchronous learn…