6533b86efe1ef96bd12cb676

RESEARCH PRODUCT

2-Cinnamamido, 2-(3-phenylpropiolamido), and 2-(3-phenylpropanamido)benzamides: synthesis, antiproliferative activity, and mechanism of action

Giuseppe DaidoneAnna CarolloErnest HamelGiandomenico AmicoBenedetta MaggioRuoli BaiMaria Valeria RaimondiMaria Grazia CusimanoRaffa DemetrioPier Giulio Conaldi

subject

Colorectal cancerAntineoplastic AgentsApoptosisPharmacologyArticleStructure-Activity RelationshipDrug DiscoveryTumor Cells CulturedmedicineHumansStructure–activity relationshipCell ProliferationPharmacologyDose-Response Relationship DrugMolecular StructureChemistryCell growthOrganic ChemistryGeneral Medicinemedicine.disease2-cinnamamidobenzamides 2-(3-phenylpropiolamido)benzamides 2-(3-phenylpropanamido)benzamides antiproliferative activity apoptosisSettore CHIM/08 - Chimica FarmaceuticaMechanism of actionApoptosisBenzamidesMCF-7 CellsNon small cellDrug Screening Assays Antitumormedicine.symptomK562 CellsChronic myelogenous leukemiaK562 cells

description

Abstract Several new benzamides 4a–q were synthesized by stirring in pyridine the acid chlorides 3a–q with the appropriate anthranilamide derivatives 2a–g. Some of the synthesized compounds were evaluated for their in vitro antiproliferative activity against a panel of 5 human cell lines (K562 human chronic myelogenous leukemia cells, MCF-7 breast cancer cells, HTC-116 and HT26 colon cancer cells and NCI H460 non-small cell lung cancer cells).

yearjournalcountryeditionlanguage
2013-05-14
10.1016/j.ejmech.2013.04.068http://hdl.handle.net/10447/93475