Search results for "Observational study"

showing 10 items of 776 documents

Reproductive medicine and inheritance of infertility by offspring: the role of fetal programming.

2011

Objective To summarize the molecular processes involved in fetal programming, to describe how assisted reproduction technologies (ART) may affect the epigenetic pattern of the embryo, and to highlight the current knowledge of the role of perinatal events in the subsequent development of reproductive pathology affecting infertile patients. Design A literature review of fetal programming of adulthood gynecologic diseases and ART. A Medline search was performed with the following keywords: (fetal programming OR epigenetics OR methylation OR acetylation) AND (IVF OR ART) AND (gynecology). Articles up to October 2010 were selected. Articles and recent reviews were classified by human and animals…

Infertilitymedicine.medical_specialtyOffspringPopulationMEDLINEReproductive medicineBioinformaticsEpigenesis GeneticPregnancymedicineHumansEpigeneticseducationGynecologyeducation.field_of_studyFetusbusiness.industryObstetrics and GynecologyDNA Methylationmedicine.diseaseReproductive MedicinePrenatal Exposure Delayed EffectsObservational studyFemalebusinessGenital Diseases FemaleInfertility FemaleFertility and sterility
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Validation Study of Italian Version of Inventory for DéJà vu Experiences Assessment (I-IDEA): A Screening Tool to Detect DéJ&agr…

2017

The Inventory Déjà Vu Experiences Assessment (IDEA) is the only screening instrument proposed to evaluate Déjà vu (DV) experience. Here we intended to validate the Italian version of IDEA (I-IDEA) and at the same time to investigate the incidence and subjective qualities of DV phenomenon in Italian healthy adult individuals on basis of an Italian multicentre observational study. In this study we report normative data on the I-IDEA, collected on a sample of 542 Italian healthy subjects aging between 18 to 70 years (average age 40, range 18-70) with a formal educational from 1-19 years. From September 2013 to March 2016 were recruited 542 healthy vo…

Informed consentJamais vuIncidence (epidemiology)Déjà vuDepersonalizationmedicineNormativeObservational studymedicine_pharmacology_behavioral_neurosciencemedicine.symptomPsychologyTest (assessment)Clinical psychology
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Higher Fluid Balance Increases the Risk of Death From Sepsis: Results From a Large International Audit

2017

Contains fulltext : 177598.pdf (Publisher’s version ) (Closed access) OBJECTIVES: Excessive fluid therapy in patients with sepsis may be associated with risks that outweigh any benefit. We investigated the possible influence of early fluid balance on outcome in a large international database of ICU patients with sepsis. DESIGN: Observational cohort study. SETTING: Seven hundred and thirty ICUs in 84 countries. PATIENTS: All adult patients admitted between May 8 and May 18, 2012, except admissions for routine postoperative surveillance. For this analysis, we included only the 1,808 patients with an admission diagnosis of sepsis. Patients were stratified according to quartiles of cumulative f…

InternationalityTime FactorsDatabases Factualmedicine.medical_treatmentlnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]Settore MED/41 - AnestesiologiaCritical Care and Intensive Care Medicinelaw.invention0302 clinical medicinelawRisk Factors80 and over030212 general & internal medicineHospital Mortality610 Medicine & healthAged 80 and overMedical Auditfluid outputMiddle AgedWater-Electrolyte Balancefluid administrationIntensive care unitfluid administration; fluid output; outcome; septic shock; Adult; Aged; Aged 80 and over; Databases Factual; Hospital Mortality; Humans; Intensive Care Units; Internationality; Medical Audit; Middle Aged; Risk Factors; Sepsis; Time Factors; Fluid Therapy; Water-Electrolyte Balance; Critical Care and Intensive Care MedicineIntensive Care UnitsCohortoutcomeHumanCohort studyAdultmedicine.medical_specialtyTime FactorSepsiIntensive Care UnitObservational StudySepsis03 medical and health sciencesDatabasesSepsisHemofiltrationmedicineJournal ArticleHumansRisk factorIntensive care medicineFactualHetastarchAgedbusiness.industrySeptic shockRisk Factor030208 emergency & critical care medicinefluid administration fluid output outcome septic shockmedicine.diseaseseptic shockFluid Therapybusiness
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PERSEUS-IT 24-month analysis: a prospective observational study to assess the effectiveness of intravitreal aflibercept in routine clinical practice …

2022

Abstract Purpose PERSEUS-IT (NCT02289924) was a prospective, observational, 2-year study evaluating the effectiveness and treatment patterns of intravitreal aflibercept (IVT-AFL) in patients with neovascular age-related macular degeneration (nAMD) in routine clinical practice in Italy. Methods Treatment-naïve patients with nAMD receiving IVT-AFL per routine clinical practice were enrolled. The primary endpoint was mean change in visual acuity (VA; decimals) from baseline to month (M) 12 and M24. Outcomes were evaluated for the overall study population and independently for the 2 treatment cohorts: regular (3 initial monthly doses, ≥ 7 injections by M12, and ≥ 4 injections between M12 and M2…

Intravitreal injectionsSettore MED/30 - Malattie Apparato VisivoRecombinant Fusion ProteinsAngiogenesis InhibitorsTreatment outcomesSensory SystemsMacular DegenerationCellular and Molecular NeuroscienceOphthalmologyReceptors Vascular Endothelial Growth FactorTreatment OutcomeRanibizumabObservational studyHumansProspective StudiesAfliberceptNeovascular age-related macular degeneration
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Diagnosis and therapeutic management of primary headache in an emergency setting

2013

Introduction and aim: Much headachers are under or mis-diagnoses and data regarding the proportion of patients attending an emergency department (ED) because of headache are still few. We conducted a retrospective observational study in an ED with the following aims: (a) estimate the proportion of headache attending to an ED (b) to estimate and describe the therapeutic management of primary headache and (c) to assessment the exam most frequently requested. Materials and methods: We collected data regarding patients diagnosed with headache consecutively attending the ED of the University of Palermo between September 2011 and March 2012. The study was approved by the ethics committee. Results: Between the semester evaluated 25110 subjects were admitted to ED headache suffers were equal to 1.6 %. Of these 263 (63.1 %) were woman and 154 (36.9 %). Mean age was 44.2 (DS ± 18.4) years (p = 0.068).According to ED registry headache admission was as follow assigned: 76.5 % with a diagnosis of headache 22.8 % with a secondary headache 0.7 % with Trigeminal Autonomic Cephalgias (TACs). Among those with a primary headache about 36 % of patient did not received a pharmacological treatment. Monotherapy was prescribed less frequently than combination therapy (19.1 vs 44.5 %).In monotherapy the most frequent medication were NSAIDs (28.3 %) benzodiazepines (26.7 %) and dopamine antagonists (11.7 %). Among those with a primary headache a CT scan was performed in the 124 subjects and 111 (34.8 %) had a neurologist consultation. Discussion: Our data are in line with the one previously reported in literature. The most frequently medication in the Italian ED were NSAIDs benzodiazepines dopamine antagonists and steroids. Neverless our data unlikely can be compared to other study give a snapshot. We believe that much more can be done to improve treatment of primary headache in ED.Settore MED/26 - Neurologia
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The Presence of White Matter Lesions Is Associated With the Fibrosis Severity of Nonalcoholic Fatty Liver Disease

2016

Abstract We tested whether nonalcoholic fatty liver disease (NAFLD) and/or its histological severity are associated with vascular white matter lesions (WML) in patients with biopsy-proven NAFLD and in non-NAFLD controls. Data were recorded in 79 consecutive biopsy-proven NAFLD, and in 82 controls with normal ALT and no history of chronic liver diseases, without ultrasonographic evidence of steatosis and liver stiffness value  45 years (OR 3.09, 95% CI: 1.06–9.06, P = 0.03; and OR 11.1, 95% CI: 1.14–108.7, P = 0.03), and F2–F4 fibrosis (OR 3.36, 95% CI: 1.29–8.73, P = 0.01; and OR 5.34, 95% CI: 1.40–20.3, P = 0.01) were independently associated with WML (mostly of mild grade) by multivariate…

Liver CirrhosisMalePathologyBiopsySeverity of Illness IndexGastroenterology0302 clinical medicineRisk FactorsNon-alcoholic Fatty Liver DiseaseFibrosisNonalcoholic fatty liver diseaseUltrasonography4500Brain DiseasesSettore MED/12 - Gastroenterologiamedicine.diagnostic_testMedicine (all)Brain DiseaseGeneral MedicineMiddle AgedMagnetic Resonance ImagingWhite MatterFrontal Lobemedicine.anatomical_structureLiverFemale030211 gastroenterology & hepatologyNAFLD liver biopsy fibrosis white matter lesionsResearch ArticleHumanmedicine.medical_specialtyLiver CirrhosiObservational StudySettore MED/08 - Anatomia PatologicaDiagnosis DifferentialWhite matter03 medical and health sciencesInternal medicineBiopsySeverity of illnessmedicineHumansbusiness.industryRisk Factornutritional and metabolic diseasesmedicine.diseasedigestive system diseasesHyperintensityDifferential diagnosisSteatosisSettore MED/36 - Diagnostica Per Immagini E Radioterapiabusiness030217 neurology & neurosurgeryMedicine
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Potentially inappropriate use of furosemide in a very elderly population: An observational study

2017

International audience; ObjectiveLittle is known about furosemide prescription modalities in elderly people. We describe furosemide prescription in ambulatory elderly patients.MethodsAll patients aged over 80 years, affiliated to Mutualité Sociale Agricole de Bourgogne, a French regional health insurance plan, with a medical prescription delivered in March 2015, were retrospectively included.ResultsAmong 15 141 patients with a median age of 86 years, comprising 61.3% of women, 3937 patients (26%) had a prescription for furosemide. Severe heart failure was the most common chronic comorbidity (27.7%). Furosemide was considered a long-term therapy for almost all patients (98.7% with prescripti…

Liver CirrhosisMalePediatricsmedicine.medical_specialtyAdrenergic beta-AntagonistsAngiotensin-Converting Enzyme InhibitorsInappropriate Prescribing[ SDV.MHEP.GEG ] Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology030204 cardiovascular system & hematologyDrug PrescriptionsNephropathy03 medical and health sciences0302 clinical medicineFurosemidemedicineHumans030212 general & internal medicineMedical prescriptionRenal Insufficiency ChronicDiureticsRetrospective StudiesAged 80 and overHeart Failurebusiness.industryAge FactorsFurosemideRetrospective cohort studyGeneral Medicinemedicine.diseaseComorbidityHeart failureAmbulatoryObservational studyFemalebusinessmedicine.drug
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High efficacy and safety of triple therapy in HCV genotype 1 and moderate fibrosis: a multicenter study of clinical practice in Spain.

2015

Background and rational. Telaprevir-based therapy (TBT) has been extensively evaluated in clinical trials. So we designed a study to compare the efficacy and safety of TBT between patients with moderate fibrosis and those suffering from advanced fibrosis in clinical practice. A multicenter observational and ambispective study was conducted. It included 582 patients with chronic hepatitis C genotype 1, 214 with fibrosis F2, and 368 with F3/F4 (F3: 148; F4: 220). Results. The mean patient age was 55 years, 67% male. Type of prior response was 22% naive, 57% relapsers, and 21% partial/null responders, 69% had high viral load (> 800,000 IU/mL). HCV genotypes were 1a (19%), 1b (69%), and 1 (12%)…

Liver CirrhosisMaleTime FactorsSpecialties of internal medicineHepacivirusGastroenterologySeverity of Illness IndexTelaprevirFibrosisRisk FactorsGenotypeGeneral MedicineMiddle AgedViral LoadTreatment OutcomeRC581-951Hepatitis C genotype 1RNA ViralDrug Therapy CombinationFemaleTelaprevir triple therapyModerate fibrosisViral loadOligopeptidesmedicine.drugAdultmedicine.medical_specialtyGenotypeAntiviral AgentsSafety and efficacyYoung AdultInternal medicinemedicineHumansAdverse effectAgedHepatologybusiness.industryInterleukinsHepatitis C Chronicmedicine.diseaseSurgeryDiscontinuationClinical trialSpainObservational studyInterferonsbusinessBiomarkersAnnals of hepatology
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Lifestyle Changes for the Treatment of Nonalcoholic Fatty Liver Disease - A 2015-19 Update.

2020

Background: Lifestyle interventions aimed at weight loss have been associated with improved liver enzymes, reduced intrahepatic triglyceride content, and improved histology (including reduced fibrosis stage). Objective: To revise the evidence on the beneficial effects of lifestyle changes accumulated since 2015, following the publication of the pivotal Cuban experience with histologic outcome. Methods: A PubMed search covering the period 2015 to July 2019 was carried out. All retrieved references were analyzed and double-checked by authors. Results: 20 new studies were identified; in addition, two relevant studies provided new evidence. Thirteen studies were classified as randomized, contr…

Liver Cirrhosismedicine.medical_specialtyFibrosiLiver CirrhosiPopulationMotivational interviewingInformation technology01 natural sciencesTriglycerideElectronic mail03 medical and health sciencesWeight lossFood intakeNon-alcoholic Fatty Liver DiseaseDrug DiscoveryNonalcoholic fatty liver diseaseWeight LossmedicineHumanseducationLife StyleTriglycerides030304 developmental biologyRandomized Controlled Trials as TopicPharmacology0303 health scienceseducation.field_of_studyInternetText MessagingCirrhosiElectronic Mailbusiness.industrymedicine.diseasePhysical activity steatosiWeight Lo0104 chemical sciencesTelephone010404 medicinal & biomolecular chemistryObservational Studies as TopicBehavior therapyCohortPhysical therapyObservational Studies as TopicObservational studymedicine.symptomBehavior therapy Cirrhosis Fibrosis Food intake Information technology Physical activity steatosisbusinessHumanCurrent pharmaceutical design
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Standardisierte pathoanatomische Befunddokumentation auf den ADT-Tumorb�gen f�r Malignome des Mundes, der Kiefer und des Gesichts (Version III)

1995

The documentation form for pathohistologic findings (version III) for tumors of the maxillofacial region is presented. It is part of the site-specific documentation of the German Association of Tumor Centers (ADT). Its handling is explained by instructions which are based on the ICD-O classification and the TNM system. The prognostic relevance of the standardized documentation has already been proven by various histomorphologic investigations concerning oral and oropharyngeal cancer. By means of a multicentric observational study the German Austrian Swiss co-operative group DOSAK will develop a new prognostic model for oral and oropharyngeal cancer.

Lymphatic metastasismedicine.medical_specialtyPathologybusiness.industryGeneral surgeryMEDLINECancermedicine.diseaselanguage.human_languagePathology and Forensic MedicineGermanDocumentationlanguagePrognostic modelMedicineNeoplasm stagingObservational studybusinessDer Pathologe
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