Search results for "Operations Research"
showing 10 items of 1297 documents
Unravelling the moderating effects of size and experience on product innovations and exports: a study in a medium knowledge-intensive industry
2012
This paper contributes to improve our knowledge on the important role of product innovation in export strategy by introducing the moderating effects of organizational variables. We argue that in a medium knowledge-intensive industry, these variables might strengthen the relationship between innovations and exports. Research on innovation and export strategy has addressed these issues increasingly during last decades; however, the divergence on the empirical approaches difficult the understanding of the linkages among variables, which are highly dependent on the industry technological characteristics. We carry out a time-lagged study using the literature-based innovation output (LBIO) method…
Exploring the relationships between maritime connectivity, international trade and domestic production
2020
The objective of this paper is to simultaneously analyse the complex relationships between bilateral maritime connectivity, bilateral trade and domestic production as measured by gross domestic pro...
Asymmetric behaviour of biotechnology business patterns in Spain
2009
Since the end of the 90s there has been an increase in the emergence of biotechnology industries in Spain, partially as a result of growing support from institutionally based infrastructures. Through the use of empirical fieldwork, this study aims to reveal how future prospects are not as optimistic as most Spanish agents perceive. Our conclusions are based on the asymmetric behaviour shown by Spanish biotechnology firms in their business models. This asymmetry is based on the overwhelming dominance of business models centred on low investment, limited R&D expenditure and minor or incremental innovation, whereas the long term–long return model, which prevails in the leading countries in thi…
Determination of Pareto frontier in multi-objective maintenance optimization
2011
Abstract The objective of a maintenance policy generally is the global maintenance cost minimization that involves not only the direct costs for both the maintenance actions and the spare parts, but also those ones due to the system stop for preventive maintenance and the downtime for failure. For some operating systems, the failure event can be dangerous so that they are asked to operate assuring a very high reliability level between two consecutive fixed stops. The present paper attempts to individuate the set of elements on which performing maintenance actions so that the system can assure the required reliability level until the next fixed stop for maintenance, minimizing both the globa…
Adapting RRI public engagement indicators to the Spanish scientific and innovation context: a participatory methodology based on AHP and content anal…
2022
The paradigm proposed by Responsible Research and Innovation in the European Commission policy discourse identifies Public Engagement as a key area for exchange and dialogue among multiple actors following an inclusive and participatory process. Two definite set of indicators have already arisen at European level to monitor Public Engagement activities in the Science and Innovation realm. Our study aims to propose a deliberative participatory process, which involves selected stakeholders, for the adaptation of the European indicators to the specific Spanish scientific and innovation context. The methodological procedure is of exploratory nature and will be based in a combination of, on the …
A survey on IVIVC/IVIVR development in the pharmaceutical industry – Past experience and current perspectives
2017
The present work aimed to describe the current status of IVIVC/IVIVR development in the pharmaceutical industry, focusing on the use and perception of specific approaches as well as successful and failed case studies. Two questionnaires have been distributed to 13 EFPIA partners of the Oral Biopharmaceutics Tools Initiative and to the Pharmacokinetics Working Party of the European Medicines Agency in order to capture the perspectives and experiences of industry scientists and agency members, respectively. Responses from ten companies and three European Agencies were received between May 21st 2014 and January 19th 2016. The majority of the companies acknowledged the importance of IVIVC/IVIVR…
A Branch-and-Cut method for the Capacitated Location-Routing Problem
2011
International audience; Recent researches in the design of logistic networks have shown that the overall distribution cost may be excessive if routing decisions are ignored when locating depots. The Location-Routing Problem (LRP) overcomes this drawback by simultaneously tackling location and routing decisions. The aim of this paper is to propose an exact approach based on a Branch-and-Cut algorithm for solving the LRP with capacity constraints on depots and vehicles. The proposed method is based on a zero-one linear model strengthened by new families of valid inequalities. The computational evaluation on three sets of instances (34 instances in total), with 5–10 potential depots and 20–88 …
Swing options in commodity markets: a multidimensional Lévy diffusion model
2013
Author's version of an article in the journal: Mathematical Methods of Operations Research. Also available from the publisher at: http://dx.doi.org/10.1007/s00186-013-0452-7 We study valuation of swing options on commodity markets when the commodity prices are driven by multiple factors. The factors are modeled as diffusion processes driven by a multidimensional Lévy process. We set up a valuation model in terms of a dynamic programming problem where the option can be exercised continuously in time. Here, the number of swing rights is given by a total volume constraint. We analyze some general properties of the model and study the solution by analyzing the associated HJB-equation. Furthermo…
A computational study of LP-based heuristic algorithms for two-dimensional guillotine cutting stock problems
2002
In this paper we develop and compare several heuristic methods for solving the general two-dimensional cutting stock problem. We follow the Gilmore-Gomory column generation scheme in which at each iteration a new cutting pattern is obtained as the solution of a subproblem on one stock sheet. For solving this subproblem, in addition to classical dynamic programming, we have developed three heuristic procedures of increasing complexity, based on GRASP and Tabu Search techniques, producing solutions differing in quality and in time requirements. In order to obtain integer solutions from the fractional solutions of the Gilmore-Gomory process, we compare three rounding procedures, rounding up, t…
Comprensión de textos expositivos académicos en e-book Reader y en papel: influencia del conocimiento previo de dominio y la aptitud verbal
2018
espanolResumen: En un estudio del que participaron 102 estudiantes universitarios, se comparo la comprension en la lectura de textos expositivos academicos impresos versus en formato de e-book Reader. Se examinaron los efectos del soporte, del conocimiento especifico de dominio previo del lector y la aptitud verbal. Asimismo se indagaron las actitudes de los estudiantes hacia los soportes textuales antes y despues de la experiencia. Los resultados sugieren que el e-book Reader beneficiaria a los lectores competentes, y/o que podria promover mayor actividad metacognitiva en los procesos de comprension. Asimismo, las opiniones hacia el e-book Reader cambiaron despues de la experiencia, aunque…