Search results for "Operative"

STN area detection using K-NN classifiers for MER recordings in Parkinson patients during neurostimulator implant surgery

2016

Deep Brain Stimulation (DBS) applies electric pulses into the subthalamic nucleus (STN) improving tremor and other symptoms associated to Parkinson's disease. Accurate STN detection for proper location and implant of the stimulating electrodes is a complex task and surgeons are not always certain about final location. Signals from the STN acquired during DBS surgery are obtained with microelectrodes, having specific characteristics differing from other brain areas. Using supervised learning, a trained model based on previous microelectrode recordings (MER) can be obtained, being able to successfully classify the STN area for new MER signals. The K Nearest Neighbours (K-NN) algorithm has bee…

An inquiry-based learning path to introduce modern physics in high-school

2018

Although Modern Physics (MP) is a scientific field of increasingly interest, due to its mathematical and conceptual difficulty, it was not generally taught in Italian high-schools. Recently, in order to reduce the gap between school curricula and modern technology, the Ministry of Education promoted the inclusion of MP in Italian secondary schools. MP hot topics produce interest and enthusiasm in learners at all ages, but to address this topic in high school in an effective way it is necessary to translate complex theories and highly-advanced experiments into an understandable language appreciated by students. In this contribution, we discuss an inquiry-driven learning sequence suitable to …

Assessment of the aesthetic impact and quality of life of home dental bleaching in adult patients

2020

Background This study aimed to evaluate the impact of home bleaching with 10% carbamide peroxide on the quality of life and aesthetic perception of patients. Material and methods A total of 107 patients between 18 and 38 years of age with good oral and general health and at least one anterior tooth in color A2 or darker were selected. Patients who previously underwent any type of bleaching procedures were excluded. All patients received a home bleaching treatment with 10% carbamide peroxide. Before beginning the bleaching treatment, the selected patients responded a form with the Oral Health Impact Profile short form (OHIP-14) and Oral Aesthetic Subjective Impact Scale (OASIS) questionnaire…

Early postoperative recurrence of severe crohnʼs disease, with colonic involvement and associated human cytomegalovirus infection, treated with oral …

2011

Shedding light on the elusive role of endothelial cells in cytomegalovirus dissemination.

2011

Cytomegalovirus (CMV) is frequently transmitted by solid organ transplantation and is associated with graft failure. By forming the boundary between circulation and organ parenchyma, endothelial cells (EC) are suited for bidirectional virus spread from and to the transplant. We applied Cre/loxP-mediated green-fluorescence-tagging of EC-derived murine CMV (MCMV) to quantify the role of infected EC in transplantation-associated CMV dissemination in the mouse model. Both EC- and non-EC-derived virus originating from infected Tie2-cre + heart and kidney transplants were readily transmitted to MCMV-naïve recipients by primary viremia. In contrast, when a Tie2-cre + transplant was infected by pri…

Clinically-based determination of safe DNAemia cutoff levels for preemptive therapy or human cytomegalovirus infections in solid organ and hematopoie…

2004

Transplantation Centers using human cytomegalovirus (HCMV) antigenemia-based preemptive therapy will need to replace in the near future the antigenemia assay with a more standardized and automatable assay, such as a molecular assay quantifying HCMV DNA in blood (DNAemia). Thus, in view of replacing antigenemia with clinically safe cutoff values, DNAemia levels corresponding to antigenemia cutoffs guiding HCMV preemptive therapy were determined retrospectively in solid organ and hematopoietic stem cell transplant recipients (HSCTR) using an "in-house" quantitative PCR (QPCR) method. Since preemptive therapy had prevented appearance of HCMV disease in all patients tested, DNA cutoffs determin…

Polo-like kinase 1 as a target for human cytomegalovirus pp65 lower matrix protein

1999

ABSTRACT Human cytomegalovirus (HCMV) pp65 protein is the major constituent of viral dense bodies but is dispensable for viral growth in vitro. pp65 copurifies with a S/T kinase activity and has been implicated in phosphorylation of HCMV IE1 immediate-early protein and its escape from major histocompatibility complex 1 presentation. Furthermore, the presence of pp65 correlates with a virion-associated kinase activity. To clarify the role of pp65, yeast two-hybrid system (THS) screening was performed to identify pp65 cellular partners. A total of 18 out of 48 yeast clones harboring cDNAs for putative pp65 binding proteins encoded the Polo-like kinase 1 (Plk1) C-terminal domain. Plk1 behaved …

Problemi di giurisdizione nel contrasto al traffico di migranti via mare

2018

I trafficanti di esseri umani si avvalgono con sempre più insistenza di ben collaudati protocolli operativi. Questi ultimi consentono loro di sottrarsi alla giurisdizione penale italiana che non si radica qualora – in ossequio ai criteri di cui all’art. 6 c.p.ed in conformità alla Convenzione sull’Alto Mare– l’azione illecita avvenga in acque internazionali.Così, premesse alcune linee concettuali sui limiti spaziali alla efficacia della legge penale, l’indagine si sofferma sulla soluzione ermeneutica offerta dallaCassazione che, apparentemente in modo sbrigativo e per esigenze di effettività della risposta punitiva, ha fatto ricorso alla controversa figura dell’autore mediato per sanzionare condott…

Osteogenesis imperfecta and hyperplastic callus formation: light- and electron-microscopic findings.

1993

In rare cases of osteogenesis imperfecta, an "overshoot" growth of new bone may occur, which, clinically gives the impression of a tumour. This condition is known as hyperplastic callus formation. Morphology showed an excessive mixed desmal-chondral osteoneogenesis. Atypical collagen fibrils in non-callus tissue represent an indicator for this callus formation in individual patients.

Microwave-induced thermoablation with Amica-probe is a safe and reproducible method to treat solid renal masses: results from a phase I study.

2012

Microwave thermal ablation (MWTA) could be considered in the future for treating small solid renal masses. The aim of the present study was to determine both the tolerability of the new Amica-probe applicator-induced MWTA used in vivo on patients with solid renal masses and the effects of heating on renal tumors and normal renal parenchyma. Fourteen patients with renal masses eligible for open radical nephrectomy were enrolled in this phase I study. All patients underwent MWTA of renal masses during the open surgery procedure before clamping of renal vascular pedicle. The effects of MWTA on patients' coagulation and tumor/renal vasculature were investigated. The histological effects of MWTA…