Search results for "Ostas"
showing 10 items of 874 documents
The Influence of Oxygen Affinity of Blood and Cerebral Blood Flow on Cerebral Oxygen Supply
1969
The quantity of oxygen transported, per unit of time, by the blood to the brain, is determined by the blood flow, the oxygen capacity, and the oxygen affinity of the blood. The O2-exchange between the blood and the tissue cells depends mainly on the oxygen transport characteristics of the blood and the O2 diffusion conditions in the blood and tissue.
Cathepsin L in Normal and Pathological Bone Remodeling
2011
Abstract Cathepsin L is a ubiquitous lysosomal cysteine endopeptidase that is mainly involved in the metabolic turnover of intracellular proteins. However, it is now well established that this enzyme may also be implicated in the regulation of other important biological processes includ- ing bone resorption. Therefore, altered expression levels of Cathepsin L may result in disturbances of bone homeo- stasis and, eventually, in the onset of pathological condi- tions associated with altered bone turnover. These observations support the concept that Cathepsin L may be regarded as an additional target for the development of novel therapeutic options for the treatment of patients with bone disea…
Physiologische Erythrozyten-Protektionslösung (PEP)
2001
Zinc and inflammatory/immune response in aging
2007
Life-long antigenic burden determines a condition of chronic inflammation, with increased lymphocyte activation and proinflammatory cytokine production. A large number of studies have documented changes in zinc metabolism in experimental animal models of acute and chronic inflammation and in human chronic inflammatory conditions. In particular, modification of zinc plasma concentration, as well as intracellular disturbance of antioxidant intracellular pathways, has been found in aging and in some age-related diseases. Zinc deficiency is diffused in aged individuals in order to avoid meat and other high zinc content foods due to fear of cholesterol. Rather, they increase the consumption of r…
Regulation of T-Cell Immune Responses by Pro-Resolving Lipid Mediators
2021
Both the initiation and the resolution of inflammatory responses are governed by the sequential activation, migration, and control/suppression of immune cells at the site of injury. Bioactive lipids play a major role in the fine-tuning of this dynamic process in a timely manner. During inflammation and its resolution, polymorphonuclear cells (PMNs) and macrophages switch from producing pro-inflammatory prostaglandins and leukotrienes to specialized pro-resolving lipid mediators (SPMs), namely, lipoxins, resolvins, protectins, and maresins, which are operative at the local level to limit further inflammation and tissue injury and restore homeostasis. Accumulating evidences expand now the rol…
D-dímeros en el recién nacido sano
2015
El sistema de coagulación neonatal es un sistema dinámico con valores de proteínas hemostáticas que cambian sobretodo en las primeras semanas y meses de vida para alcanzar valores de adulto alrededor de los seis meses de vida postnatal para la mayoría de ellas. En neonatos, la elevación de los D-dímeros se consideran como el biomarcador más sensible de la fibrinolisis secundaria a la activación previa de la coagulación ante la existencia de un trombo. Estudios en población adulta y niños mayores de un año han demostrado su aplicabilidad práctica debido a su elevada sensibilidad y valor predictivo negativo. Existen pocos estudios publicados de valores de D-dímeros en recién nacidos sanos. Hi…
Model wielowymiarowej profilaktyki pozytywnej w teorii i praktyce pedagogicznej
2019
Artykuł opisuje teoretyczne oraz empiryczne założenia autorskiego modelu wielowymiarowej profilaktyki pozytywnej. Ponadto prezentuje sposób jego urzeczywistnienia w praktyce pedagogicznej, przedstawiając strukturę autorskiego programu profilaktycznego Wsparcie wielowymiarowego rozwoju młodzieży, zrealizowanego wśród wychowanków Domu Dziecka w Chmielowicach. Teoretyczne podstawy modelu odnoszą się do teorii głównych i teorii szczegółowych. Natomiast założenia empiryczne sprowadzają się do metodyki konstruowania programów profilaktycznych, a więc kryteriów doboru i metod oddziaływań profilaktycznych, uczestników oraz strategii ewaluacyjnej. Model wielowymiarowej profilaktyki pozytywnej w prak…
A ceRNA analysis on LMNA gene focusing on the Hutchinson-Gilford progeria syndrome
2013
Background: Hutchinson-Gilford progeria syndrome is a rare dominant human disease of genetic origin. The average life expectancy is about 20 years, patients’ life quality is still very poor and no efficient therapy has yet been developed. It is caused by mutation of the LMNA gene, which results in accumulation in the nuclear membrane of a particular splicing form of Lamin-A called progerin. The mechanism by which progerin perturbs cellular homeostasis and leads to the symptoms is still under debate. Micro-RNAs are able to negatively regulate transcription by coupling with the 3’ UnTranslated Region of messenger RNAs. Several Micro-RNAs recognize the same 3’ UnTranslated Region and each Micr…
The Copper-microRNA Pathway Is Integrated with Developmental and Environmental Stress Responses in Arabidopsis thaliana
2021
As an essential nutrient, copper (Cu) scarcity causes a decrease in agricultural production. Cu deficiency responses include the induction of several microRNAs, known as Cu-miRNAs, which are responsible for degrading mRNAs from abundant and dispensable cuproproteins to economize copper when scarce. Cu-miRNAs, such as miR398 and miR408 are conserved, as well as the signal transduction pathway to induce them under Cu deficiency. The Arabidopsis thaliana SQUAMOSA-PROMOTER BINDING PROTEIN-LIKE (SPL) family member SPL7 binds to the cis-regulatory motifs present in the promoter regions of genes expressed under Cu deficiency, including Cu-miRNAs. The expression of several other SPL transcription f…
Datortomogrāfija mugurkaula L5 -S1 līmeņa diska patoloģijas gadījumā
2016
Muguras lejasdaļas sāpes ir 26, 4 % pieaugušo, diska patoloģijas slimības gadījumos, 90% tieši tiek skarti mugurkaula jostas daļas L4-L5 un L5-S1 līmeņi. Ne vienmēr rentgenogrāfiski ir iespējams iegūt vispārēju priekšstatu par mugurkaula asi un izmaiņām skriemeļu ķermeņos, tāpēc informācijai par diska patoloģiju pielieto datortomogrāfijas izmeklējumus, kuros ļoti svarīgi ir pielietot atbilstošus tehniskos parametrus un izprast kvalitātes kritērijus protokola standartiem. Darbā tiek analizēta un aprakstīta literatūra par tēmu: “Datortomogrāfija mugurkaula L5-S1 līmeņa diska patoloģijas gadījuma”. Teorētiskajā daļā aprakstīta mugurkaula jostas daļas normāla anatomija, radioloģiskā anatomija, …