Search results for "Oxide"

showing 10 items of 6424 documents

Toxicity as prime selection criterion among SARS-active herbal medications

2021

We present here a new selection criterion for prioritizing research on efficacious drugs for the fight against COVID-19: the relative toxicity versus safety of herbal medications, which were effective against SARS in the 2002/2003 epidemic. We rank these medicines according to their toxicity versus safety as basis for preferential rapid research on their potential in the treatment of COVID-19. The data demonstrate that from toxicological information nothing speaks against immediate investigation on, followed by rapid implementation of Lonicera japonica, Morus alba, Forsythia suspensa, and Codonopsis spec. for treatment of COVID-19 patients. Glycyrrhiza spec. and Panax ginseng are ranked in …

2019-20 coronavirus outbreakmedicine.medical_specialtyRelative toxicityCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Pharmaceutical ScienceReviewSARS-CoV-2 severe acute respiratory syndrome coronavirus 203 medical and health sciencesCytochrome P450 Phytochemicals0302 clinical medicineSOD superoxide dismutaseDrug DiscoveryMedicineAnimalsHumansOral applicationIKK inhibitor of κB kinase030304 developmental biologyPharmacologyRational phytotherapy0303 health sciencesPublic healthCOVID-19 Coronavirus disease 2019JNK c-Jun N-terminale kinaseNO nitric oxidePlants MedicinalTraditional medicineToxicityACE2 angiotensin converting enzyme 2business.industrySARS-CoV-2Public healthCOVID-19Th2 T helper cells type 2NF-κB nuclear factor- κ B cellsComplementary and alternative medicine030220 oncology & carcinogenesisToxicityMolecular MedicineCYP cytochrome P450 monooxygenaseHIV-1 human immunodeficiency virus 1businessSelection criterionMAPK mitogen-activated protein kinaseDrugs Chinese HerbalPhytomedicine
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Extra-virgin olive oils storage: Effect on constituents of biological significance

2021

Abstract The high oxidative stability of virgin olive oil with respect to other vegetable oils is mainly due to its fatty acid composition, in particular, to the high monounsaturated-to-polyunsaturated ratio, and to the presence of minor compounds that play a major role in preventing oxidation. In spite of its high stability, virgin olive oil is susceptible to oxidative processes, such as enzymatic oxidation, photooxidation, and autoxidation, which mainly occur during processing and storage. Generally, extra-virgin olive oil has a relatively long shelf life of 16–18 months of storage at room temperature. The study of shelf life is generally based on determining of quality parameters (acidit…

34-DHPEA-EA oleuropein aglyconPUFA polyunsaturated fatty acidAutoxidationEVOO extra-virgin olive oilChemistry34-DHPEA-EDA oleacinSFA saturated fatty acidMUFA monounsaturated fatty acidStorage effectShelf lifePeroxideDAc-10-OH Ole Agly deacetoxy-oleuropein aglyconp-HPEA tyrosolp-HPEA-EDA oleocanthalchemistry.chemical_compoundBiological significancep-HPEA-EA ligstroside aglyconHydroxytyrosolDegradation (geology)Food scienceFatty acid compositionhydroxytyrosol
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CCDC 788373: Experimental Crystal Structure Determination

2010

Related Article: C.Rizzoli, P.Astolfi, E.Marku, L.Greci|2010|Acta Crystallogr.,Sect.E:Struct.Rep.Online|66|o1986|doi:10.1107/S1600536810026176

3-Benzyl-3-hydroxy-2-phenyl-3H-indole 1-oxideSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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Evaluation of the antibacterial power and biocompatibility of zinc oxide nanorods decorated graphene nanoplatelets: New perspectives for antibiodeter…

2017

Background Nanotechnologies are currently revolutionizing the world around us, improving the quality of our lives thanks to a multitude of applications in several areas including the environmental preservation, with the biodeterioration phenomenon representing one of the major concerns. Results In this study, an innovative nanomaterial consisting of graphene nanoplatelets decorated by zinc oxide nanorods (ZNGs) was tested for the ability to inhibit two different pathogens belonging to bacterial genera frequently associated with nosocomial infections as well as biodeterioration phenomenon: the Gram-positive Staphylococcus aureus and the Gram-negative Pseudomonas aeruginosa. A time- and dose-…

3003Staphylococcus aureuslcsh:Medical technologyBiocompatibilitylcsh:Biotechnologyharmful to the environmentBiomedical EngineeringPharmaceutical ScienceMedicine (miscellaneous)Overall; ZNGs represent a promising candidate for developing biocompatible materials that can be exploitable in antimicrobial applications without releasing toxic compounds; harmful to the environment; Bioengineering; Medicine (miscellaneous); Molecular Medicine; Biomedical Engineering; Applied Microbiology and Biotechnology; 3003Biocompatible MaterialsBioengineeringNanotechnology02 engineering and technology010402 general chemistry01 natural sciencesApplied Microbiology and BiotechnologyNanomaterialsExtracellular polymeric substancelcsh:TP248.13-248.65HumansZNGs represent a promising candidate for developing biocompatible materials that can be exploitable in antimicrobial applications without releasing toxic compoundNanotubesbiologyChemistryResearchBiofilm021001 nanoscience & nanotechnologybiology.organism_classificationAntimicrobialAnti-Bacterial Agents0104 chemical scienceslcsh:R855-855.5NanotoxicologyBiofilmsPseudomonas aeruginosaZNGs; biodeterioration; antimicrobial nanomaterialMolecular MedicineGraphiteNanorodOverallZinc Oxide0210 nano-technologyBacteria
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Enhanced adhesion and in situ photothermal ablation of cancer cells in surface-functionalized electrospun microfiber scaffold with graphene oxide

2017

The physicochemical characteristics of a biomaterial surface highly affect the interaction with living cells. Recently, much attention has been focused on the adhesion properties of functional biomaterials toward cancer cells, since is expected to control metastatic spread of a tumor, which is related to good probability containing the progression of disease burden. Here, we designed an implantable poly(caprolactone)-based electrospun microfiber scaffold, henceforth PCLMF-GO, to simultaneously capture and kill cancer cells by tuning physicochemical features of the hybrid surface through nitrogen plasma activation and hetero-phase graphene oxide (GO) covalent functionalization. The surface i…

3003business.product_categoryCancer therapyPharmaceutical ScienceNanotechnologyBiocompatible Materials02 engineering and technologyCell capture010402 general chemistry01 natural scienceslaw.inventionPlasmalawNeoplasmsMicrofiberCell AdhesionHumansCell adhesionGraphene oxideHybrid materialChemistryGrapheneBiomaterialOxidesAdhesionPhotothermal therapyPhototherapy021001 nanoscience & nanotechnology0104 chemical sciencesPolycaprolactoneCancer cellMCF-7 CellsSurface modificationGraphite0210 nano-technologybusiness
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Characterization of the Solid State Properties of Anodic Oxides on Magnetron Sputtered Ta, Nb and Ta-Nb Alloys

2012

Tantalum oxide, niobium oxide and Ta-Nb containing mixed oxides were grown by anodizing sputter-deposited Ta, Nb and Ta-Nb alloys of different compositions. A photoelectrochemical investigation was performed in order to estimate the band gap and the flat band potential of the oxides as a function of their composition. The band gap of the investigated Ta-Nb containing mixed oxides changed monotonically between those estimated for Ta2O5 (4.1 eV) and Nb2O5 (3.4 eV) and in agreement with a proposed correlation between the Band gap of an oxide and the difference of electronegativity of the oxide constituents. From the differential capacitance curves recorded in a wide range of electrode potentia…

431Materials scienceRenewable Energy Sustainability and the EnvironmentSolid-stateCondensed Matter PhysicsSolid State Properties Anodic Oxides Ta-Nb AlloysSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsCharacterization (materials science)AnodeSettore ING-IND/23 - Chimica Fisica ApplicataChemical engineeringCavity magnetronMaterials ChemistryElectrochemistry
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Endohedral Mixed Aggregates: Sodium Alkoxide Cages with Organic or Inorganic Central Anions and Variable Hull.

2021

Abstract Alkali metal alkoxides are widely used in chemistry due to their Brønsted basic and nucleophilic properties. Potassium alkoxides assist alkyllithium in the metalation of hydrocarbons in Lochmann‐Schlosser‐bases. Both compounds form mixed aggregates, which enhance the thermal stability, solubility, and the basic reactivity of these mixtures. A very unusual spherical mixed alkoxy aggregate was discovered by Grützmacher et al., where a central dihydrogen phosphide anion is surrounded by a highly dynamic shell of thirteen sodium atoms and a hull of twelve tert‐butoxide groups. This structural motif can be reproduced by a reaction of trimethylsilyl compounds of methane, halogens, or pse…

540 Chemistry and allied sciencesMetalationSodiumalkoxidechemistry.chemical_elementHot Paper010402 general chemistry01 natural sciencesCatalysischemistry.chemical_compoundPolymer chemistryNucleophilic substitutionReactivity (chemistry)isotopic labelingsodiumFull Paper010405 organic chemistryOrganic ChemistryaggregationGeneral ChemistryFull PapersAlkali metal0104 chemical scienceschemistry540 ChemieAlkoxideHalogenAlkoxy groupcage compoundsChemistry (Weinheim an der Bergstrasse, Germany)
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Acid‐Cleavable Poly(ethylene glycol) Hydrogels Displaying Protein Release at pH 5

2020

Abstract PEG is the gold standard polymer for pharmaceutical applications, however it lacks degradability. Degradation under physiologically relevant pH as present in endolysosomes, cancerous and inflammatory tissues is crucial for many areas. The authors present anionic ring‐opening copolymerization of ethylene oxide with 3,4‐epoxy‐1‐butene (EPB) and subsequent modification to introduce acid‐degradable vinyl ether groups as well as methacrylate (MA) units, enabling radical cross‐linking. Copolymers with different molar ratios of EPB, molecular weights (M n) up to 10 000 g mol−1 and narrow dispersities (Đ<1.05) were prepared. Both the P(EG‐co‐isoEPB)MA copolymer and the hydrogels showed pH‐…

540 Chemistry and allied sciencesVinyl CompoundsBiocompatible MaterialsDegree of polymerization010402 general chemistry01 natural sciencesCatalysisPolyethylene GlycolsPolymerizationchemistry.chemical_compoundHydrolysisPolymer chemistryPEG ratioCopolymermedicinehydrogelsPolymer Technologieschemistry.chemical_classificationFull PaperEthylene oxide010405 organic chemistryHydrolysisOrganic ChemistryBiochemistry and Molecular BiologyProteinsprotein releaseHydrogelsGeneral ChemistryPolymerFull PapersHydrogen-Ion ConcentrationVinyl etherPolymerteknologiPEG0104 chemical sciencescopolymerizationchemistry540 Chemiedrug deliverySelf-healing hydrogelsMethacrylatesBiokemi och molekylärbiologimedicine.drugChemistry – A European Journal
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CCDC 1526002: Experimental Crystal Structure Determination

2017

Related Article: Aleksandrs Pustenko, Dmitrijs Stepanovs, Raivis Žalubovskis, Daniela Vullo, Andris Kazaks, Janis Leitans, Kaspars Tars, Claudiu T. Supuran|2017|J.Enzyme Inhib.Med.Chem.|32|767|doi:10.1080/14756366.2017.1316720

7-nitro-3H-12-benzoxathiepine 22-dioxideSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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Thermomineral waters of Greece: geochemical characterization

2020

75 °C). In terms of pH most results vary from 5.5 to 823 °C) ii) warm (23 40 °C) iii) thermal (40 75 °C) and iv) hyperthermal (&gtfew springs show either very low pH (&lt10) proposing serpentinization processes. Regarding TDS concentrations collected waters can be subdivided into low salinity (up to 1.5 g/L) brackish (up to 20 g/L) and saline (up to 43 g/L). The medium high salinities can be justified by mixing with sea water and/or strong waterrock interaction processes. Isotope composition of O and H ranges from 12.7 to +2.7 ‰ SMOW and from 91 to +12 ‰ SMOW respectively and is generally comprised between the Global Meteoric Water Line and the East Mediterranean Meteoric Water Line. Only few water samples show a positive shift for δ18O possibly related to high temperature waterrock interaction processes. Carbon dioxide (18 997000 μmol/mol) or N2 (1100 989000 μmol/mol) or CH4 (&ltMany geothermal areas of Greece are located in regions affected by Miocene or Quaternary volcanism and in continental basins characterised by elevated heat flow. Moreover the majority of them is found along the coast as well as in islands of the Aegean Sea and thus thermal water is often brackish to saline due to marine intrusion into costal aquifer. In the present study almost 300 thermal and cold mineral water samples were collected along the Hellenic territory with their physicochemical parameters (temperature pH electrical conductivity and Eh) and the amount of bicarbonates (titration with 0.1N HCl) being determined in situ. Additionally gases found either in free or dissolved phase were sampled. Both water and gas samples were analysed at the INGVPa laboratories for major ions (Ion Chromatography) silica (Inductively Coupled Plasma Optical Emission Spectrometry) chemical composition of free and dissolved gases (Gas Chromatography) water isotopes (O and H) and carbon and helium isotopes of free and dissolved gases (Mass Spectrometry). The temperature of the investigated waters ranges from 6.5 to 98°C pH from 1.96 to 11.98 whilst Total Dissolved Solids (TDS) from 0.06 to 43 g/L. Based on the temperature parameter waters can be divided into four groups: i) cold (&lt0.5 913000 μmol/mol) are the prevailing gas species found in the studied sites. The δ13CCO2 values ranged from 20.1 to +8.5 ‰ whilst the isotope ratio of He from 0.21 to 6.71 R/RA.4) suggesting interaction with H2Srich gases or very high pH values (&gtSettore GEO/08 - Geochimica E Vulcanologia
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