Search results for "PAB"

showing 10 items of 372 documents

Building on Entrepreneurs’ Leadership through ‘Lean’ and Dynamic Performance Management Systems in Small and Micro Firms. Challenges and Missed Oppor…

2014

This paper frames the potential benefits of ‘lean’ and dynamic performance management (PM) systems for small and micro enterprises. In this context, the ‘lean’ attribute is used to characterize a different approach in applying PM to small firms, in respect to larger organizations. In fact, such systems may exploit the entrepreneur’s tacit knowledge and build on leadership, by incorporating individual attributes into organizational routines. Related to small and micro firms, direct experience and case-studies suggest that their sudden crises and demises are often a product of gradual – internal and external – phenomena that entrepreneurs are not enabled to selectively and promptly detect and…

System DynamicLeadershipCase-StudiesEntrepreneurial CapabilitieSettore SECS-P/07 - Economia AziendaleInsight ModelLean and Dynamic Performance ManagementSmall and Micro Firm
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Exploring the Link between ICT and Development in the Context of Developing Countries : A Literature Review

2014

Published version of an article in the journal: Electronic Journal of Information Systems in Developing Countries. Also available from the publisher at: http://www.ejisdc.org/ojs2/index.php/ejisdc/article/view/1332. Open Access The article contributes to the ongoing discussion on relating information and communication technology (ICT) to development (D). The quest to relate ICT to D is a topic of open deliberation and critical scrutiny in ICT4D research communities. To enhance the understanding in this regard, we conducted a literature review. The review examines 80 articles to identify various development theories and the role of technologies in the development process. While scanning the …

Systemvetenskap informationssystem och informatik med samhällsvetenskaplig inriktningKnowledge managementScrutinycapability approachliterature reviewProcess (engineering)media_common.quotation_subjectInformation Systems Social aspectsContext (language use)02 engineering and technologyDevelopmental stage theories020204 information systemsPolitical science0502 economics and business0202 electrical engineering electronic engineering information engineeringRelevance (information retrieval)media_commonbusiness.industry05 social sciencesdeveloping countriesVDP::Social science: 200DeliberationICT4DInformation and Communications TechnologyCapability approach050211 marketingVDP::Social science: 200::Library and information science: 320::Information and communication systems: 321businessInformation Systems
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DECORIN EFFECTS ON PROTEOMIC PROFILING OF BREAST CANCER CELLS: AN UPDATED STUDY

2015

The malignant carcinomas are characterized by several capabilities acquired by the neoplastic cells, among which the ability to invade the extracellular matrix (ECM) and to establish a crosstalk with several ECM components. Under this respect, the extracellular microenvironment is an entity extraordinarily rich of information with opposite signals. Our group has long undertaken the study of the effects of ECM molecules on the behavior of cancer cells in vitro. Among the studied molecules, the decorin was found to exert a non-permissive effect on the growth and motility of the transfected tumor cells. The decorin, belongs to the family of small leucine-rich proteoglycans (SLRP) and is involv…

The malignant carcinomas are characterized by several capabilities acquired by the neoplastic cells among which the ability to invade the extracellular matrix (ECM) and to establish a crosstalk with several ECM components. Under this respect the extracellular microenvironment is an entity extraordinarily rich of information with opposite signals. Our group has long undertaken the study of the effects of ECM molecules on the behavior of cancer cells in vitro. Among the studied molecules the decorin was found to exert a non-permissive effect on the growth and motility of the transfected tumor cells. The decorin belongs to the family of small leucine-rich proteoglycans (SLRP) and is involved physiologically in the fibrillogenesis of collagen. In the last few year a new anti-oncogenic role has been proposed for decorin1. This study aimed to implement the knowledge on the effects of ectopic decorin on breast cancer cells using as a reference point the results already achieved by our research group2 on the experimental model format. By breast cancer cell line 8701-BC and its transfected clone DEC-C2. The extension of the proteomic analysis combined with the mass spectrometry allowed to triplicate the number of identified proteins in our model. Among the newly identified proteins were members of the classes of metabolic enzymes S100 family and cell motility proteins which revealed a net decrease in the decorin transfected cells. Of considerable importance is the observation that these classes of proteins are the most involved in metastatic progression. These results confirm and reinforce the anti-oncogenic role hypothesized for decorin. The work was co-funded by the Italian 5x1000 to COBS.DECORIN
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Building collective capabilities through ICT in a mountain region of Nepal: where social capital leads to collective action

2012

In this paper, we explore how ICT can lead to development specifically human development in Sen's capability approach. In answering to the critique that Sen views capabilities as the individual, we incorporate the societal level by adding collective capabilities. We propose that ICT helps to create or enhance SC of communities which in turn can lead to development by building collective capabilities through collective action. To illustrate, we conducted a qualitative case study of an ICT initiative in a remote mountain region of Nepal. We found support for our proposition and further that developing collective capabilities also simultaneously enhanced individual capabilities. We contribute …

Theory buildingKnowledge managementPublic AdministrationComputer sciencebusiness.industryEnvironmental resource managementDevelopmentCollective actionSocietal levelHuman development (humanity)Computer Science ApplicationsInformation and Communications TechnologyCapability approachbusinessSocial capitalInformation Technology for Development
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POSS-tetraalkylammonium salts: A new class of ionic liquids

2012

A series of new polyhedral oligomeric silsesquioxane ionic liquids (POSS-ILs) based on the trimethylpropylammonium dielectric constants, which, conversely, display slight differences originating from the nature of the anions. The long alkyl-chain substituents on the POSS core infer on this series of ILs an overall hydrophobic character and solution properties comparable to those of classic cationic surfactants, resulting in an effective extractant capability of polyanions from aqueous solutions. Their solution diffusion properties, as investigated by room-temperature dynamic light scattering, solution conductivity, density, and osmometric measurements, do not provide evidence for the occurr…

Thermogravimetric analysisAqueous solutionChemistryDielectricConductivitySilsesquioxaneionic liquids; self-assembly; Structure–activity relationships; Extraction capability; SilsesquioxanesInorganic Chemistrychemistry.chemical_compoundDifferential scanning calorimetryDynamic light scatteringPOSS Ionic LiquidIonic liquidPhysical chemistryOrganic chemistrySettore CHIM/02 - Chimica Fisica
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Analyser l'action publique de vie étudiante à l'aune de la théorie des capabilités

2021

International audience; Cette intervention présente des premiers résultats d'une thèse CIFRE à la Ville de Paris et au laboratoire IREDU sur le rôle des grandes métropoles dans la lutte contre la précarité étudiante. Elle reviendra sur l'apport des capabilités et d'une approche mixte pour appréhender l'action publique locale parisienne. Une évaluation d'un dispositif d'aide au logement et de la coordination locale a été menée afin de déceler les écarts entre le public initialement visé et le public réellement atteint. L'approche innovante des capabilités permet ainsi d'aller au-delà des libertés formelles pour mieux orienter les politiques de vie étudiante.

Théorie des capabilités[SHS.EDU]Humanities and Social Sciences/Education[SHS.EDU] Humanities and Social Sciences/EducationÉtudiantGouvernancePolitique localePrécaritéAction publique
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The eSourcing Capability Model for Service Providers: Knowledge Manage-ment across the Sourcing Life-cycle

2011

Laaksonen, Pekka The eSourcing Capability Model for Service Providers: Knowledge Manage-ment across the Sourcing Life-cycle Jyväskylä: Jyväskylän yliopisto, 2011, 42 s. Tietojärjestelmätiede, kandidaatintutkielma Ohjaaja(t): Käkölä, Timo Tässä kandidaatintutkielmassa selvitettiin sitä, miten the eSourcing Capability Model for Service Providers-mallin käytännöt (practices) ovat liittyneet tietä-myksenhallinnan neljään prosessiin: tiedon luominen, varastointi/noutaminen, jakaminen ja hyödyntäminen. Tutkielma suoritettiin kirjallisuus katsauksena. Tutkimus ongelmaa lähestyttiin taulukoimalla mallin käytännöt matriisiin, jos-sa vaaka-akselilla olivat palvelutuotannon elinkaaren vaiheet ja pysty…

Tietämyksen hallintaTietämysthe eSourcing Capability Model for Service Providers
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Enzymatically hydrolyzed low-density lipoprotein modulates inflammatory responses in endothelial cells

2009

SummaryThere is evidence that low-density lipoprotein (LDL) is modified by hydrolytic enzymes,and that the product (E-LDL) induces selective production of interleukin 8 (IL-8) in endothelial cells. Since nuclear factor-kappaB (NF-κB) is a major regulator of IL-8 transcription, we studied its activation in endothelial cells treated with E-LDL. Unexpectedly,the modified lipoprotein not only failed to activate NF-κB, but completely blocked its activation by tumour necrosis factor-alpha (TNF-α) in EA.hy926-cells, as assessed by electrophoretic mobility shift assays and immunofluorescence. Inhibition occurred upstream of NF-κB translocation, as inhibitor of NF-κB- (IκB)-phosphorylation was suppr…

Time FactorsProto-Oncogene Proteins c-junPyridinesmedicine.medical_treatmentFatty Acids NonesterifiedBiologyp38 Mitogen-Activated Protein KinasesCell Linechemistry.chemical_compoundNF-KappaB Inhibitor alphamedicineHumansTrypsinInterleukin 8PhosphorylationPromoter Regions GeneticProtein Kinase InhibitorsTranscription factorInflammationTumor Necrosis Factor-alphaActivator (genetics)HydrolysisInterleukin-8ImidazolesTranscription Factor RelAEndothelial CellsNF-κBHematologySterol EsteraseMolecular biologyLipoproteins LDLTranscription Factor AP-1Endothelial stem cellCytokineBiochemistrychemistryLow-density lipoproteinI-kappa B ProteinsLipoproteinThrombosis and Haemostasis
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Global retention models and their application to the prediction of chromatographic fingerprints

2020

Abstract The resolution of samples containing unknown compounds of different nature, or without standards available, as is the case of chromatographic fingerprints, is still a challenge. Possibly, the most problematic aspect that prevents systematic method development is finding models that describe without bias the retention behaviour of the compounds in the samples. In this work, the use of global models (able to describe the whole sample) is proposed as an alternative to the use of individual models for each solute. Global models contain parameters that are specific for each solute, while other parameters ‒related to the column and solvent‒ are common for all solutes. A special regressio…

Time FactorsResolution (mass spectrometry)Predictive capability010402 general chemistry01 natural sciencesBiochemistryHigh-performance liquid chromatographyAnalytical ChemistryComputer SimulationChromatographySulfonamidesChromatographyPlant ExtractsChemistryElution010401 analytical chemistryOrganic ChemistryChamomileWaterGeneral MedicineModels TheoreticalReference StandardsMethod development0104 chemical sciencesRegression AnalysisGradient elutionAlgorithmsJournal of Chromatography A
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The Importance of Internal Resources and Capabilities and Destination Resources to Explain Firm Competitive Position in the Spanish Tourism Industry

2015

This study draws on the Resource-Based View to analyze the effects of distinctive competences in tourism firms and location in a tourism district on competitive position, and explores the moderating effects of the tourism destination. Multiple linear regression was used to test the research hypotheses on a sample of 1019 Spanish tourism firms. Results reveal that financial resources and dynamic and production capabilities favor a better competitive position for tourism firms in general; however, coordination and marketing capabilities are key factors for firms embedded in a tourism district, while dynamic capabilities have a negative effect in this case. Copyright © 2015 John Wiley & Sons, …

Tourism geography05 social sciencesGeography Planning and DevelopmentTransportationSample (statistics)Key factorsResource (project management)Tourism Leisure and Hospitality Management0502 economics and businessEconomicsPosition (finance)Production (economics)MarketingDynamic capabilities050203 business & management050212 sport leisure & tourismTourismNature and Landscape ConservationInternational Journal of Tourism Research
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