Search results for "PAM"
showing 10 items of 1768 documents
Storage and release of false transmitters after infusion of (+)- and (?)-?-methyldopamine
1971
Rabbits were given an infusion of 10 mg/kg (−)- or 30 mg/kg (+)-α-methyldopamine and killed after 135 min. The noradrenaline content of the heart was decreased to 26±5 and 34±2%, respectively, of the control value. After infusion of the (+)-isomer the missing noradrenaline was replaced by (−)-α-methylnoradrenaline. Electrical stimulation of the sympathetic nerves or infusion of acetylcholine plus atropine caused an output of noradrenaline and (−)-α-methylnoradrenaline from the isolated heart. The two amines were released in the same proportion as they were stored in the heart and the total output of both amines equalled the output of noradrenaline from control hearts. Nerve stimulation caus…
Mode and mechanism of neurotensin action in rat proximal colon
1997
Abstract This study examined the mechanism of action of neurotensin on intraluminal pressure in rat proximal colon. The direct and indirect contractile response to neurotensin (100 nM) was abolished in Ca 2+ -free solution, and was antagonized by nifedipine (1–5–10 nM) and potentiated by Bay K 8644 (methyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl)-pyridine-5-carboxylate) (10–100–1000 nM). Neurotensin, in the presence of nifedipine (10 nM) and atropine (1 μM), induced a tetrodotoxin-insensitive inhibitory effect, which was antagonized by SR 48692 (2[(1-(7-chloro-4-quinolinyl)-5-(2,6-dimethoxy-phenyl)pyrazol-3-yl) carbonyl amino]tricyclo (3.3.1.1. 3.7 ) decan-2-carboxylic a…
Jaunākā pirmsskolas vecuma bērnu pamatkustību apguve kustību rotaļās
2020
Bakalaura darba autors: Signe Vecozola Bakalaura darba temats: Jaunākā pirmsskolas vecuma bērnu pamatkustību apguve kustību rotaļās. Darba mērķis: Teorētiski izzināt un praktiski pamatot kustību rotaļu nozīmi bērnu pamatkustību apguvē. Darba teorētiskajā daļā tiek teorētiski izzinātas pedagogu un psihologu atziņas par kustību rotaļu nozīmi bērna veselībā un attīstībā. Tiek vērsta uzmanība uz jaunākā pirmskolas vecuma bērnu attīstības raksturojumu. Tiek apskatīta un izzināta rotaļa, tās veidi un tās ietekme uz pamatkustību apguvi. Kā arī tiek izzināta kustību rotaļa, kā jaunākā pirmsskolas vecuma bērnu pamatkustību apguves sekmētāja. Darba praktiskajā daļā tika veikts empīriskais pētījums, p…
Fuzzy set qualitative comparative analysis (fsQCA) applied to the adaptation of the automobile industry to meet the emission standards of climate cha…
2021
Abstract Facing global climate change challenges entails a sustainable development of transportation. Governments and automobile manufacturers are highly aware of how a large-scale deployment of Electric Vehicles (EVs) can reduce greenhouse gas (GHG) emissions and mitigate global warming. This study aids the design of the adaptation strategies of the automotive industry to meet global goals on climate change by means of a fuzzy-set qualitative comparative analysis (fsQCA), which makes it possible to measure the level of actors’ satisfaction. This allows identification of a combination of factors leading to the outcome while dealing with uncertain environments due to the heterogeneous nature…
Effects of dopamine infusion on plasma catecholamines in preterm and term newborn infants.
1991
Newborn infants (21 preterm and 13 term) received dopamine infusions at a low (2.5-3.4 micrograms/kg per min) and/or high (5-10 micrograms/kg per min) infusion rate and changes in plasma catecholamines were monitored. The mean baseline values for dopamine, noradrenaline and adrenaline were between 240 and 560, 125 and 144 and 62 and 82 pg/ml, respectively. During low-rate infusion of dopamine, there was a significant increase in plasma dopamine (20-100 fold), noradrenaline (three- to five-fold) and adrenaline (threefold). Administration of dopamine at the high rate resulted in an even larger increase in the plasma catecholamines (dopamine, 100-300 fold; noradrenaline, seven- to eightfold; a…
VentQsys: Low-cost open IoT system for CO2 monitoring in classrooms
2021
AbstractIn educational context, a source of nuisance for students is carbon dioxide ($$CO_2$$ C O 2 ) concentration due to closed rooms and lack of ventilation or circulatory air. Also, in the pandemic context, ventilation in indoor environments has been proven as a good tool to control the COVID-19 infections. In this work, it is presented a low cost IoT-based open-hardware and open-software monitoring system to control ventilation, by measuring carbon dioxide ($$CO_2$$ C O 2 ), temperature and relative humidity. This system provides also support for automatic updating, auto-self calibration and adds some Cloud and Edge offloading of computational features for mapping functionalities. From…
Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberine
2012
Neutrophil gelatinase-associated lipocalin (NGAL, a.k.a Lnc2) is a member of the lipocalin family and has diverse roles. NGAL can stabilize matrix metalloproteinase-9 from autodegradation. NGAL is considered as a siderocalin that is important in the transport of iron. NGAL expression has also been associated with certain neoplasias and is implicated in the metastasis of breast cancer. In a previous study, we examined whether ectopic NGAL expression would alter the sensitivity of breast epithelial, breast and colorectal cancer cells to the effects of the chemotherapeutic drug doxorubicin. While abundant NGAL expression was detected in all the cells infected with a retrovirus encoding NGAL, t…
El libro de los ganaderos y pastores
A la port.: Modo de adquirir los ganados, contratación del ganado en feria... vicios redhibitorios. Penas... por el pastoreo.
Preparation of dopaminergic N-alkyl-benzyltetrahydroisoquinolines using a 'one-pot' procedure in acid medium.
2000
The preparation of N-methyl-BTHIQ (4) from N-phenylethyl-phenacetamide (1) by cyclization, reduction and N-alkylation in acid medium has been achieved in good yield in a 'one-pot' procedure. Acylation of imine (2) intermediate afforded the Z and E stereoselectivity in the enamide formation. 6-Hydroxy-BTHIQ (7) shows selectivity for D2 dopamine receptors, while its N-methylated homologue (8) displays higher affinities for both D1 and D2 receptor types, with an unexpected increase in D1 dopamine receptor affinity.
Latviešu valodas apguves sekmēšana pirmsskolas vecuma bērniem bilingvālā vidē mazākumtautību pirmsskolas izglītības iestādē
2021
Bakalaura darba tēma “Latviešu valodas apguves sekmēšana pirmsskolas vecuma bērniem bilingvālā vidē mazākumtautību pirmsskolas izglītības iestādē” Darba autore: Arita Tirne Pētījuma mērķis: teorētiski pētīt divvalodīgu bērnu valodas apguves sekmēšanu pirmsskolas vecumā un apkopot ieteikumus. Darbs sastāv no divām nodaļām – teorētiskās un empīriskās. Teorētiskajā nodaļā tiek analizēta zinatniskā literatūra. Kā arī izpētīts bilingvālās izglītības mērķis bērnu attīstībā un bilingvālas izglītības īpatnības pirmsskolas izglītības līmenī. Tiek pamatots, cik bilingvālā izglītība ir nozīmīga runas un intelekta attīstībai. Kā arī atspoguļota bilingvālā attīstība pirmsskolas vecuma bērniem, faktori, …