Search results for "PAM"
showing 10 items of 1768 documents
P-56LOCAL BLOCKADE OF THE MU OPIOID RECEPTOR REVEALS THE DUAL MOTOR EFFECT OF ETHANOL IN pVTA
2015
Previous electrophysiological and behavioral data have revealed the existence of ethanol opposite effects (excitatory and inhibitory) on the posterior ventral tegmental area (pVTA) dopamine (DA) neurons activity. These activating and depressing effects of ethanol could be the result of two concurrent and opposing mechanisms, one increasing and the other reducing GABA release …
SY26-2ACETALDEHYDE ENDOCANNABINOIDS AND DOPAMINE: IS THIS –JUST- “A MENAGE A TROIS”?
2015
As ethanol, its first metabolite, acetaldehyde (ACD), enhances dopamine neurotransmission and exerts rewarding and motivational effects in animal models tailored for studying addictive-like behaviours. The endocannabinoid system fine-tuning dopamine cell activity, affects distinct drug-related behaviours and specific drug-induced effects. In light of this, it becomes urgent to investigate the implications of …
Acetaldehyde effects in the brain
2015
The effects of alcohol have been widely studied during the past century as alcohol abuse is a major health problem in Western society. In the last years, a growing body of evidence indicates that acetaldehyde, the first oxidation product of ethanol, is one of the mediators of peripheral and central effects of ethanol. Indeed, acetaldehyde has been recently taken into account as the mediator of the rewarding properties of alcohol. The role of acetaldehyde in ethanol-related properties has been proved by enzymatic manipulation studies in which the inactivation of acetaldehyde potentially synthesized in the brain produces the same results as blocking the formation of acetaldehyde by inhibiting…
Ética para la inteligencia artificial sostenible
2022
Este artículo está sujeto a una licencia CC BY 4.0
Sustainable artificial intelligence and constructive ethical assessment
2022
Este artículo esta sujeto a una licencia CC BY 4.0
Musikmoderne als Mittel der Standortbestimmung eines "geistigen deutschen Juden". Ein Blick auf Arnold Schönberg in einer Vorkriegsnovelle Arnold Zwe…
2020
The aim of this article is to present the concept of "Europamüdigkeit" described by the German-Jewish writer Arnold Zweig (1887-1968) in his early work. The analysed novella titled "Quartettsatz von Schönberg" from 1913 is focused on a young emigrant who is exhausted with the European culture and encounters the music of Viennese modernism, bringing a totally new perception of the old continent.
Papel de la Demografía en la Transición a Sociedades Sostenibles
2020
Abstract: Currently, although the global population has surpassed 7.5 billion and continues to increase in about 80 million each year, attention to demography is almost absent in most of the studies and publications related to the current situation of planetary emergency and the necessary transition to sustainable societies. For this reason, our first aim in this paper has been to discuss if this current lack of attention to demography is justified or not. With this purpose, we begin considering the scientific meaning of Sustainability, in order to overlay distorted and impoverish views of this concept that may hinder our study. Then, we analyse the reasons given by experts for and against …
Fibroblast growth factor-21 enhances mitochondrial functions and increases the activity of PGC-1α in human dopaminergic neurons via Sirtuin-1
2014
Abstract Mitochondrial dysfunctions accompany several neurodegenerative disorders and contribute to disease pathogenesis among others in Parkinson’s disease (PD). Peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) is a major regulator of mitochondrial functions and biogenesis, and was suggested as a therapeutic target in PD. PGC-1α is regulated by both transcriptional and posttranslational events involving also the action of growth factors. Fibroblast growth factor-21 (FGF21) is a regulator of glucose and fatty acid metabolism in the body but little is known about its action in the brain. We show here that FGF21 increased the levels and activity of PGC-1α and elevated mito…
Iegurņa pamatnes disfunkcijas risku noteikšana grūtniecēm un to nozīme prevencijas taktikai nākotnē
2019
Iegurņa pamatnes disfunkcija veidojas iegurņa pamatnes muskuļu un saistaudu vājuma vai traumas rezultātā un biežākās izpausmes sevī ietver iegurņa orgānu prolapsu, urīna inkontinenci vai fekālu inkontinenci. Šī problēma skar lielu daļu sieviešu populācijas pasaulē un tiek saistīta ar būtisku ietekmi uz dzīves kvalitāti. Līdz šim nav bijušas metodes kā identificēt augsta riska pacientes, tādējādi nav arī izveidotas vadlīnijas par prevencijas iespējām. Darba mērķis ir aprēķināt iegurņa pamatnes disfunkcijas attīstības risku sievietēm, kuras stacionētas Rīgas Dzemdību namā un pēc literatūras datiem izvērtēt iespējamās prevencijas iespējas atbilstoši iegūtajam riskam. Tika izvirzīti pieci darba…
Prenatal diazepam exposure functionally alters the GABA(A) receptor that modulates [3H]noradrenaline release from rat hippocampal synaptosomes.
2002
In rats, exposure to diazepam (DZ) during the last week of gestation is associated with behavioral alterations (in some cases sexually dimorphic) that appear when the animals reach adulthood. This study was conducted to evaluate the effects of prenatal DZ exposure on the function of the gamma-aminobutyric (GABA)(A) receptor complex. The method used - perfusion of rat hippocampal nerve terminals labeled with [3H]noradrenaline (NA) - allowed us to evaluate the effects of DZ on a specific native GABA(A) receptor subtype which is located on hippocampal noradrenergic nerve endings and mediates the release of NA. Muscimol stimulated synaptosomal release of [3H]NA in a concentration-dependent mann…