Search results for "PAP"

On the Quest for Defining Organisational Plasticity: A Community Modelling Experiment

2020

PurposeThis viewpoint article is concerned with an attempt to advance organisational plasticity (OP) modelling concepts by using a novel community modelling framework (PhiloLab) from the social simulation community to drive the process of idea generation. In addition, the authors want to feed back their experience with PhiloLab as they believe that this way of idea generation could also be of interest to the wider evidence-based human resource management (EBHRM) community.Design/methodology/approachThe authors used some workshop sessions to brainstorm new conceptual ideas in a structured and efficient way with a multidisciplinary group of 14 (mainly academic) participants using PhiloLab. Th…

Defectus natalium. Un cas paradigmatique du pouvoir pontifical de dispense (XIe-XVe siècle)

2016

According to the canon law of the first half of the XIIth century, sons of priests and canons are not allowed to be promoted to sacred orders nor to succeed to their fathers. Yet the merita and the morum honestas of the sons can compensate for the vitia of the fathers. That explains that papal dispensations super defectu natalium are very common a long time before Boniface VIII (1295-1303) resolves the jurisdictional issue of who may grant a dispensation (pope, bishops or abbots) and for which cases (major or minor orders). Letters and letter formularies of the Apostolic Penitentiary – a papal office which arises at the beginning of the XIIIth century, answers to the supplications addressed…

Widening the applicability of AnMBR for urban wastewater treatment through PDMS membranes for dissolved methane capture: Effect of temperature and hy…

2021

[EN] AnMBR technology is a promising alternative to achieve future energy-efficiency and environmental-friendly urban wastewater (UWW) treatment. However, the large amount of dissolved methane lost in the effluent represents a potential high environmental impact that hinder the feasibility of this technology for full-scale applications. The use of degassing membranes (DM) to capture the dissolved methane from AnMBR effluents can be considered as an interesting alternative to solve this problem although further research is required to assess the suitability of this emerging technology. The aim of this study was to assess the effect of operating temperature and hydrodynamics on the capture of…

Paper-based vs computer-based exams in CS1

2016

In this study, we examine the "test mode effect" in CS1 exam using the Rainfall problem. The participants started working with pen and paper, after which they had access to a computer, and they could rework their solution with a help of a test suite developed by the authors. In the computer- based phase many students were able to fix the errors that they had committed during the paper-based phase. These errors included well-known corner cases, such as empty array or division by zero.

Costanza d'Aragona, Isabella di Brienne

2006

Role of NK1 and NK2 receptors in mouse gastric mechanical activity

2006

1. The aim of the present study was to examine the role of NK1 and NK2 receptors in the control of mechanical activity of mouse stomach. In this view, the motor effects induced by NK1 and NK2 receptor agonists and antagonists were analyzed, measuring motility as intraluminal pressure changes in mouse-isolated stomach preparations. In parallel, immunohistochemical studies were performed to identify the location of NK1 and NK2 receptors on myenteric neurons and smooth muscle cells. 2. Substance P (SP) induced biphasic effects: a contraction followed by relaxation; neurokinin A (NKA) and [beta-Ala8]-NKA(4-10), selective agonist of NK2 receptors, evoked concentration-dependent contractions, whe…

Scientific power in the Spanish press during the Pandemic : a portrait of new leaders while explaining its risk

2021

This work is based on the mediatisation of society theory, which establishes more attached importance and the presence of the mass media as mediators in various social processes, as well as on Production Studies, that analyse creative skills to draw an audience, to apply these theories to the media representation of the COVID-19 pandemic. The objective is to analyse how the generalist media have represented male/female scientists, who have become social benchmarks during the first COVID-19 wave in Spain. Our initial hypothesis considers that the purpose of the mediatisation of scientific discourse was to contribute answers to, and to keep society calm, in an uncertainty context. By content …

Effects of Some Directly-Acting Smooth Muscle Relaxant Drugs on Isolated Human Preparations of the Upper Urinary Tract

1985

It is generally assumed that drugs which induce relaxation of smooth muscles may be of clinical importance in some urological disorders; such drugs are indeed widely used, for example in the therapy of unstable bladders or to facilitate the passage of ureteral stones. Antispasmodic action may be classified in neurotropic and musculo-tropic action; the former acting on the autonomic nervous system and the latter directly on smooth muscle cells. Examples for the first type of action are anticholinergic drugs or alpha-adrenoceptor-antagonists, whereas papaverine is a classic drug with the second type of action.

Microscopic interactions between ivermectin and key human and viral proteins involved in SARS-CoV-2 infection

2021

The identification of chemical compounds able to bind specific sites of the human/viral proteins involved in the SARS-CoV-2 infection cycle is a prerequisite to design effective antiviral drugs. Here we conduct a molecular dynamics study with the aim to assess the interactions of ivermectin, an antiparasitic drug with broad-spectrum antiviral activity, with the human Angiotensin-Converting Enzyme 2 (ACE2), the viral 3CLpro and PLpro proteases, and the viral SARS Unique Domain (SUD). The drug/target interactions have been characterized in silico by describing the nature of the non-covalent interactions found and by measuring the extent of their time duration along the MD simulation. Results …

VAR modeļu un kointegrācijas analīzes pielietojums zelta cenas analīzē

2017

Darbs tiek veltīts kointegrācijai un kļūdas korekcijas modelim. Darbā dots ieskats par vienības saknes testiem, vektoru autoregresijas vienādojumiem, kointegrāciju, kļūdu korekciju modeļiem. Metodes tika pielietotas pētot sakarības starp tādiem valūtu pāriem kā zelts pret ASV dolāru (XAU/USD) un Šveices franks pret ASV dolāru (CHF/USD). Ar Engla-Greinžera un Johansena metodēm parādīts, ka periodā no 2011. gada maija līdz 2016. gada decembrim pastāv kointegrācija starp iepriekš minētajiem instrumentiem.