Search results for "PBM"
showing 5 items of 15 documents
Anti-Inflammatory Effects of Nutritionally Relevant Concentrations of Oleuropein and Hydroxytyrosol on Peripheral Blood Mononuclear Cells: An Age-Rel…
2023
: Immunosenescence and inflammaging facilitate the insurgence of chronic diseases. The Mediterranean diet is a non-invasive intervention to improve the chronic low-grade inflammatory status associated with aging. Olive oil oleuropein (OLE) and hydroxytyrosol (HT) demonstrated a controversial modulatory action on inflammation in vitro when tested at concentrations exceeding those detectable in human plasma. We studied the potential anti-inflammatory effects of OLE and HT at nutritionally relevant concentrations on peripheral blood mononuclear cells (PBMCs) as regards cell viability, frequency of leukocyte subsets, and cytokine release, performing an age-focused analysis on two groups of subj…
Some Plant Defense Stimulators can induce IL-1β production in human immune cells in vitro
2020
8 pages; International audience; Among Plant Protection Products (PPP), a new emerging category of pesticides act by stimulating plant defense in order to improve plant resistance against microbial pathogens. Given that these compounds, the so-called Plant Defense Stimulators (PDS) act on innate immunity, we tested, using an in vitro approach on human mononuclear leucocytes (PBMC), the potential toxicity (XTT assay) and inflammatory effects (production of IL-1β) of 4 PPP belonging to different chemical families. We found that two products (LBG-01F34® and Regalis®) did not induce any cytotoxicity or IL-1 β production. The product BION-50 WG®, that contains Acibenzolar-S-methyl (ASM) and sili…
Apoptotic-like Leishmania exploit the host´s autophagy machinery to reduce T-cell-mediated parasite elimination
2015
Apoptosis is a well-defined cellular process in which a cell dies, characterized by cell shrinkage and DNA fragmentation. In parasites like Leishmania, the process of apoptosis-like cell death has been described. Moreover upon infection, the apoptotic-like population is essential for disease development, in part by silencing host phagocytes. Nevertheless, the exact mechanism of how apoptosis in unicellular organisms may support infectivity remains unclear. Therefore we investigated the fate of apoptotic-like Leishmania parasites in human host macrophages. Our data showed--in contrast to viable parasites--that apoptotic-like parasites enter an LC3(+), autophagy-like compartment. The compartm…
Depletion of
2020
Child obesity constitutes a risk factor for developing insulin resistance which, if sustained, could lead to more severe conditions like type 2 diabetes (T2D) in adulthood. Our study identified previously unknown species whose depletion (Blautia luti and Blautia wexlerae) is associated with insulin resistance in obese individuals. Our results also indicate that these bacterial species might help to reduce inflammation causally linked to obesity-related complications. Childhood is considered a window of opportunity to tackle obesity. These new findings provide, therefore, valuable information for the future design of microbiota-based strategies for the early prevention of obesity-related com…
Personīgās izaugsmes iespējas BSC darbinieku perspektīvā. Gadījuma izpēte
2021
Maģistra darba mērķis ir izpētīt, kādā veidā PBM process ietekmē to, kā darbinieki uztver un realizē savu pašizaugsmi. Ņemot vērā, ka PBM modelis ir kļuvis par pašsaprotamu instrumentu daudzās organizācijās, domājot par uzņēmuma un darbinieku attīstību, manā pētījumā tas kļūst par platformu kur satiekas darbinieku vēlmes pēc izaugsmes un uzņēmuma vajadzības pēc progresējošiem darbiniekiem. Kā galveno konceptuālo pieeju es izmantoju Burdjē (Bourdieu) lauka teoriju. Pētījums atklāj, ka tas, kas padara izaugsmi par darbinieku vēlmju objektu ir tās “dabiskošana”, fetišizēšana un padarīšana par stratēģisku instrumentu, veidojot savu profesionālo imidžu. Tas, kā darbinieki realizē savu izaugsmi, …