Search results for "PD"
showing 10 items of 1971 documents
Exploiting the Opportunity to Use Plant-Derived Nanoparticles as Delivery Vehicles
2023
The scientific community has become increasingly interested in plant-derived nanoparticles (PDNPs) over the past ten years. Given that they possess all the benefits of a drug carrier, including non-toxicity, low immunogenicity, and a lipid bilayer that protects its content, PDNPs are a viable model for the design of innovative delivery systems. In this review, a summary of the prerequisites for mammalian extracellular vesicles to serve as delivery vehicles will be given. After that, we will concentrate on providing a thorough overview of the studies investigating the interactions of plant-derived nanoparticles with mammalian systems as well as the loading strategies for encapsulating therap…
Absence of Adverse Effects of Tiotropium/Olodaterol Compared with the Monocomponents on Long-Term Heart Rate and Blood Pressure in Patients with Mode…
2020
Stefan Andreas,1,2 Lorcan McGarvey,3 Ulrich Bothner,4 Matthias Trampisch,4 Alberto de la Hoz,4 Matjaz Fležar,5 Roland Buhl,6 Peter Alter7 1Department of Cardiology and Pneumology, University Medical Center Göttingen, Göttingen, Germany; 2LungClinic Immenhausen, Immenhausen, Germany, Member of the German Center for Lung Research (DZL); 3Queen’s University Belfast, Belfast, UK; 4Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany; 5Klinika Golnik, Golnik, Slovenia; 6Pulmonary Department, Johannes Gutenberg University Mainz, Mainz, Germany; 7Department of Medicine, Pulmonary and Critical Care Medicine, Philipps University of Marburg (UMR); Member o…
Starpdisciplināro studiju programmu kvalitātes novērtēšana
2015
Maģistra darba tēma: Starpdisciplināro studiju programmu kvalitātes novērtēšana. Darba autore: Alīna Ļebedeva. Zinātniskais darba vadītājs: Dr. paed., profesore Ilze Ivanova. Maģistra darba apjoms: 57 lpp., ietverti 3 attēli, izmantotas 46 literatūras vienības, pievienoti 2 pielikumi. Pētījuma mērķis: izstrādāt kritērijus starpdisciplināro studiju programmu kvalitātes novērtēšanai. Darbs sastāv no 3 nodaļām – divām teorētiskām un empīriskās nodaļas. Pirmajā nodaļā izstrādātas dažas izglītības kvalitātes definīcijas un analizēti jautājumi, saistīti ar augstākās izglītības kvalitātes novērtēšanu Latvijā. Otrajā nodaļā izpētīti jautājumi saistībā ar starpdisciplinārajām studiju programmām. Emp…
Dažādu formu un izmēru objektu pielietojums stiklveida ķermeņa apduļķojumu simulācijai un detektēšanai
2018
Bakalaura darbs ir uzrakstīts latviešu valodā uz 32 lapām. Tas satur 22 attēlu, 4 tabulas, un 29 atsauces uz literatūras avotiem. Darba mērķis: Noskaidrot labākos objektus stiklveida ķermeņa apduļķojumu simulācijai un detektēšanai. Metode: Stiklveida ķermeņa apduļķojumu simulācijai izmantotas fotolitogrāfijas metodes, savukārt, to detektēšanai izmantots Kanija malu detektors. Rezultāti un analīze: Aptuveni 50 % no struktūrām, kuru izmērs ir 5-25 mikroni tika detektēti. Gaismas intensitātes sadalījums liecina par veiksmīgu difrakcijas ainas iegūšanu. Secinājumi: Struktūras kuru izmērs ir no dažiem mikroniem līdz dažiem desmitiem mikronu ir vislabāk pielietojamas stiklveida ķermeņa apduļķojum…
Robežlīmeņa personības traucējumu izplatība studentiem Latvijā
2021
Nosaukums: “Robežlīmeņa personības traucējumu izplatība studentiem Latvijā.” Ievads: Robežlīmeņa personības traucējumi (RPT) vispārējā populācijā ir aptuveni 1%. Savukārt universitātes un koledžas studentu populācijā šis skaitlis var sasniegt vidēji pat 16,5%, jo studenti saskaras ar lielu stresu, kas kombinējoties ar nediagnosticētiem RPT un sabiedrības spiedienu nelabvēlīgi ietekmē studentus ilgtermiņā. Mērķi: Noteikt RPT izplatību studentu populācijā Latvijā, salīdzināt to izplatību saistībā ar dzimumu un vecumu. Materiāli un metodes: Šķērsgriezuma pilotpētījums tika veikts Latvijā tiešsaistes aptaujas veidā laika posmā no 2021.gada 1.februāra līdz 1.martam COVID-19 pandēmijas laikā. Lai…
A Sub-Supersolution Approach for Robin Boundary Value Problems with Full Gradient Dependence
2020
The paper investigates a nonlinear elliptic problem with a Robin boundary condition, which exhibits a convection term with full dependence on the solution and its gradient. A sub- supersolution approach is developed for this type of problems. The main result establishes the existence of a solution enclosed in the ordered interval formed by a sub-supersolution. The result is applied to find positive solutions.
Regular solutions for nonlinear elliptic equations, with convective terms, in Orlicz spaces
2022
We establish some existence and regularity results to the Dirichlet problem, for a class of quasilinear elliptic equations involving a partial differential operator, depending on the gradient of the solution. Our results are formulated in the Orlicz-Sobolev spaces and under general growth conditions on the convection term. The sub- and supersolutions method is a key tool in the proof of the existence results.
The Radó–Kneser–Choquet theorem for $p$-harmonic mappings between Riemannian surfaces
2020
In the planar setting the Rad\'o-Kneser-Choquet theorem states that a harmonic map from the unit disk onto a Jordan domain bounded by a convex curve is a diffeomorphism provided that the boundary mapping is a homeomorphism. We prove the injectivity criterion of Rad\'o-Kneser-Choquet for $p$-harmonic mappings between Riemannian surfaces. In our proof of the injecticity criterion we approximate the $p$-harmonic map with auxiliary mappings that solve uniformly elliptic systems. We prove that each auxiliary mapping has a positive Jacobian by a homotopy argument. We keep the maps injective all the way through the homotopy with the help of the minimum principle for a certain subharmonic expressio…
Location of solutions for quasi-linear elliptic equations with general gradient dependence
2017
Existence and location of solutions to a Dirichlet problem driven by $(p,q)$-Laplacian and containing a (convection) term fully depending on the solution and its gradient are established through the method of subsolution-supersolution. Here we substantially improve the growth condition used in preceding works. The abstract theorem is applied to get a new result for existence of positive solutions with a priori estimates.
Do electrospray mass spectra of surfactants mirror their aggregation state in solution?
2011
One important feature in the gas phase chemistry of surfactants is to ascertain whether their aggregates produced by electrospray ionization reflect those formed in the starting solution. With this aim, we have performed ESI-MS, ESI-MS/MS and ER-MS spectra of bis(2-ethylhexyl)sulfosuccinate (AOTNa) solutions in different solvents, i.e. water, water/methanol, methanol and n-hexane. The results clearly indicate that, notwithstanding the strongly different aggregation state in solution (direct micelles in water and in water/methanol, molecular dispersion in methanol and reverse micelles in n-hexane) and marked effects of the solvent polarity on the total ionic current, the surfactant aggregate…