Search results for "PD"

Redox regulation of genome stability by effects on gene expression, epigenetic pathways and DNA damage/repair

2015

Reactive oxygen and nitrogen species (e.g. H2O2, nitric oxide) confer redox regulation of essential cellular signaling pathways such as cell differentiation, proliferation, migration and apoptosis. In addition, classical regulation of gene expression or activity, including gene transcription to RNA followed by translation to the protein level, by transcription factors (e.g. NF-κB, HIF-1α) and mRNA binding proteins (e.g. GAPDH, HuR) is subject to redox regulation. This review will give an update of recent discoveries in this field, and specifically highlight the impact of reactive oxygen and nitrogen species on DNA repair systems that contribute to genomic stability. Emphasis will be placed …

Identification of subdominant sourdough lactic acid bacteria and their evolution during laboratory-scale fermentations

2007

Abstract Presumptive lactic acid bacterial cocci were found in six sourdoughs (out of 20) from the Abruzzo region (central Italy) and subjected to phenotypic and genotypic characterization. A total of 21 isolates, recognized as seven strains by randomly amplified polymorphic DNA (RAPD)–polymerase chain reaction (PCR) typing, were identified by a polyphasic approach, consisting of 16S rRNA gene sequencing, multiplex PCR assays and physiological features, as Enterococcus faecium and Pediococcus pentosaceus. Four strains belonging to those species and previously isolated from wheat kernels were inoculated in sterile flour to verify their capacity to grow in sourdough environment. Doughs with s…

Recovery of time-dependent coefficients from boundary data for hyperbolic equations

2019

We study uniqueness of the recovery of a time-dependent magnetic vector-valued potential and an electric scalar-valued potential on a Riemannian manifold from the knowledge of the Dirichlet to Neumann map of a hyperbolic equation. The Cauchy data is observed on time-like parts of the space-time boundary and uniqueness is proved up to the natural gauge for the problem. The proof is based on Gaussian beams and inversion of the light ray transform on Lorentzian manifolds under the assumptions that the Lorentzian manifold is a product of a Riemannian manifold with a time interval and that the geodesic ray transform is invertible on the Riemannian manifold.

GERDA (GERman-Dmp Asthma) – GERNOD (GERmaN-cOdp-Dmp): Effektivität der Disease Management Programm Asthma bronchiale und COPD

2019

Treatment Initiation in Therapy-Naive COPD Patients: An Analysis of the German Real-Life Daccord Register

2020

Sprachatlas von Nordostbayern, Hermann Scheuringer (Hg.). 2014. Einführung von Johann Schmuck; Sprachatlas von Nordostbayern, Robert Hinderling (Hg.)…

2015

Characterization of five sour orange clones through molecular markers and leaf essential oils analysis.

2006

Five clones of sour orange (Citrus aurantium L.) showing significant morphological differences were selected from our germplasm collection and characterized both by genetic and leaf volatiles analysis. The genetic studies were undertaken by the use of molecular markers developed by PCR-based techniques (ISSR and RAPD), while the leaf essential oil patterns were obtained by chromatographic and mass spectrometric determination. Data obtained suggest that reasonably similar information can be achieved from the two techniques, supporting each other in characterization studies.

Trends in sleeping difficulty among adolescents in five Nordic countries 2002–2014

2019

Sleep has been found to be an important factor in adolescents’ mental and physical health. The aim of the present study was to examine trends in sleep difficulty (i.e., difficulty falling asleep more often than once a week) in the Nordic countries among 11- to 15-year-olds. We analysed Nordic data from the Health Behaviour in School-aged Children study (HBSC), which is conducted every four years, looking specifically at trends in sleep difficulty over a 12-year period from 2002 to 2014. The participants were aged 11 to 15 years. The total number of participants across these years was 113,447. A large percentage (17% to 31% in 2014) of adolescents in the Nordic countries experience sleep dif…

IκB kinase-driven nuclear factor-κB activation in patients with asthma and chronic obstructive pulmonary disease.

2011

Background Nuclear factor-κB (NF-κB) is a transcriptional factor of different inflammatory patterns involved in asthma and chronic obstructive pulmonary disease (COPD) that is tightly controlled by IκB kinase (IKK) complex. Objective We investigated the dysregulation of IKK-driven NF-κB activation in patients with asthma and COPD. Methods We assessed IKKα and IKKβ expression and activation, their regulation by glucocorticosteroids, and their involvement in IL-8 synthesis in PBMCs isolated from asthmatic patients, healthy smokers (HSs), patients with COPD, and control subjects. PBMCs from control subjects were stimulated with TNF-α and cigarette smoke extract in the presence or absence of fl…

Determination of 3-MCPD by GC-MS/MS with PTV-LV injector used for a survey of Spanish foodstuffs

2007

3-Monochloropropane-1,2-diol (3-MCPD) is the most common chemical contaminant of the group of chloropropanols. It can occur in foods and food ingredients at low levels as a result of processing, migration from packaging materials during storage and domestic cooking. A sensitive method for determination of 3-MCPD in foodstuffs using programmable temperature vaporization (PTV) with large-volume injection (LVI) gas chromatography (GC) with tandem mass spectrometry detection (MS/MS) has been developed and optimized. The optimization of the injection and detection parameters was carried out using statistical experimental design. A Plackett-Burman design was used to estimate the influence of reso…